(64 nodes) GnRH signaling pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102360076	Protein kinase domain-containing protein. (286 aa)
	PLCB4	Phosphoinositide phospholipase C. (919 aa)
	LOC102354262	Mitogen-activated protein kinase. (330 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	GNRHR	Type I gonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1425 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	ATF4	Activating transcription factor 4. (374 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
	PLA2G4F	Phospholipase A2. (785 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	LOC102361286	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (505 aa)
	ADCY5-2	AC_N domain-containing protein. (323 aa)
	HBEGF	Heparin binding EGF like growth factor. (209 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	SRC	Tyrosine-protein kinase. (535 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1340 aa)
	LOC102359416	Uncharacterized protein. (359 aa)
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1408 aa)
	PLD2-2	Uncharacterized protein. (392 aa)
	LOC102351267	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
	MAPK10	Mitogen-activated protein kinase 10. (342 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2a. (301 aa)
	GNRH2	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (86 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	PLCB1	Phosphoinositide phospholipase C. (1034 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (658 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	MMP2	Matrix metallopeptidase 2. (653 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	GNAS	GNAS complex locus. (377 aa)
	GNRHR-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (338 aa)
	LOC102345989	Uncharacterized protein. (92 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	LOC102346610	G_PROTEIN_RECEP_F1_2 domain-containing protein. (419 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (332 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	CDC42	Cell division cycle 42. (156 aa)
	CALML4	Calmodulin like 4. (165 aa)
	LOC102350357	Uncharacterized protein. (577 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
	MAPK12	Uncharacterized protein. (103 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2064 aa)
	GNRHR2/nmI	Gonadotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
	LOC102360885	Luteinizing hormone, beta polypeptide. (130 aa)
	LOC102363355	ETS domain-containing protein. (380 aa)
	GNRHR1/III	G_PROTEIN_RECEP_F1_2 domain-containing protein. (389 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAPK8	Mitogen-activated protein kinase. (437 aa)
	CALML6	Calmodulin like 6. (160 aa)
	MMP14	Matrix metallopeptidase 14. (597 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	ADCY5-2	ENSLACP00000004616	ENSLACP00000006513	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.962
ADCY4	ADCY6	ENSLACP00000004616	ENSLACP00000019614	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.971
ADCY4	ADCY8	ENSLACP00000004616	ENSLACP00000011649	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.949
ADCY4	ADCY9	ENSLACP00000004616	ENSLACP00000007634	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.960
ADCY4	GNAS	ENSLACP00000004616	ENSLACP00000015123	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.967
ADCY4	LOC102362951	ENSLACP00000004616	ENSLACP00000007730	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.920
ADCY4	PRKACB	ENSLACP00000004616	ENSLACP00000014312	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.920
ADCY5-2	ADCY4	ENSLACP00000006513	ENSLACP00000004616	AC_N domain-containing protein.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.962
ADCY5-2	ADCY6	ENSLACP00000006513	ENSLACP00000019614	AC_N domain-containing protein.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.900
ADCY5-2	ADCY8	ENSLACP00000006513	ENSLACP00000011649	AC_N domain-containing protein.	AC_N domain-containing protein.	0.946
ADCY5-2	ADCY9	ENSLACP00000006513	ENSLACP00000007634	AC_N domain-containing protein.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.987
ADCY5-2	GNAS	ENSLACP00000006513	ENSLACP00000015123	AC_N domain-containing protein.	GNAS complex locus.	0.965
ADCY5-2	LOC102362951	ENSLACP00000006513	ENSLACP00000007730	AC_N domain-containing protein.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.920
ADCY5-2	PRKACB	ENSLACP00000006513	ENSLACP00000014312	AC_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.920
ADCY6	ADCY4	ENSLACP00000019614	ENSLACP00000004616	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.971
ADCY6	ADCY5-2	ENSLACP00000019614	ENSLACP00000006513	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.900
ADCY6	ADCY8	ENSLACP00000019614	ENSLACP00000011649	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.946
ADCY6	ADCY9	ENSLACP00000019614	ENSLACP00000007634	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.958
ADCY6	GNAS	ENSLACP00000019614	ENSLACP00000015123	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GNAS complex locus.	0.966
ADCY6	LOC102362951	ENSLACP00000019614	ENSLACP00000007730	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.936