(78 nodes) Melanogenesis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102360076	Protein kinase domain-containing protein. (286 aa)
	PLCB4	Phosphoinositide phospholipase C. (919 aa)
	LOC102354262	Mitogen-activated protein kinase. (330 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
	TYRP1	Tyrosinase related protein 1. (536 aa)
	H2ZYH3_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (578 aa)
	LOC102364515	Uncharacterized protein. (221 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1092 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (577 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	LOC102361286	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	ADCY5-2	AC_N domain-containing protein. (323 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1340 aa)
	LOC102362951	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	GNAI1	G protein subunit alpha i1. (326 aa)
	CREB3	cAMP responsive element binding protein 3. (452 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (408 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (329 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2a. (301 aa)
	TYR	Tyrosinase. (532 aa)
	DCT	Dopachrome tautomerase. (521 aa)
	ADCY8	AC_N domain-containing protein. (266 aa)
	PLCB1	Phosphoinositide phospholipase C. (1034 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	LOC102361424	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
	POMC	Proopiomelanocortin. (255 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	GNAS	GNAS complex locus. (377 aa)
	LOC102345989	Uncharacterized protein. (92 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	DVL3	Dishevelled segment polarity protein 3. (716 aa)
	TCF7L2-2	Transcription factor 7 like 2. (180 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	H3B5C9_LATCH	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	CALML4	Calmodulin like 4. (165 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	EDN1	Endothelin 1. (216 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	ADCY6	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (894 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	GNAI3	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	DVL1	Dishevelled segment polarity protein 1. (552 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	LOC102350297	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	CALML6	Calmodulin like 6. (160 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CREBBP	CREB binding protein. (2411 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	ADCY5-2	ENSLACP00000004616	ENSLACP00000006513	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.962
ADCY4	ADCY6	ENSLACP00000004616	ENSLACP00000019614	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.971
ADCY4	ADCY8	ENSLACP00000004616	ENSLACP00000011649	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	AC_N domain-containing protein.	0.949
ADCY4	ADCY9	ENSLACP00000004616	ENSLACP00000007634	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.960
ADCY4	GNAI1	ENSLACP00000004616	ENSLACP00000008403	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.944
ADCY4	GNAI3	ENSLACP00000004616	ENSLACP00000020114	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.944
ADCY4	GNAS	ENSLACP00000004616	ENSLACP00000015123	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.967
ADCY4	LOC102361424	ENSLACP00000004616	ENSLACP00000013070	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.944
ADCY4	LOC102362951	ENSLACP00000004616	ENSLACP00000007730	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.920
ADCY4	PRKACB	ENSLACP00000004616	ENSLACP00000014312	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.920
ADCY5-2	ADCY4	ENSLACP00000006513	ENSLACP00000004616	AC_N domain-containing protein.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.962
ADCY5-2	ADCY6	ENSLACP00000006513	ENSLACP00000019614	AC_N domain-containing protein.	Adenylate cyclase 6; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.900
ADCY5-2	ADCY8	ENSLACP00000006513	ENSLACP00000011649	AC_N domain-containing protein.	AC_N domain-containing protein.	0.946
ADCY5-2	ADCY9	ENSLACP00000006513	ENSLACP00000007634	AC_N domain-containing protein.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.987
ADCY5-2	GNAI1	ENSLACP00000006513	ENSLACP00000008403	AC_N domain-containing protein.	G protein subunit alpha i1.	0.934
ADCY5-2	GNAI3	ENSLACP00000006513	ENSLACP00000020114	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.934
ADCY5-2	GNAS	ENSLACP00000006513	ENSLACP00000015123	AC_N domain-containing protein.	GNAS complex locus.	0.965
ADCY5-2	LOC102361424	ENSLACP00000006513	ENSLACP00000013070	AC_N domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a.	0.934
ADCY5-2	LOC102362951	ENSLACP00000006513	ENSLACP00000007730	AC_N domain-containing protein.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.920
ADCY5-2	PRKACB	ENSLACP00000006513	ENSLACP00000014312	AC_N domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.920