(17 nodes) Mixed, incl. Nuclear receptor coactivator, interlocking, and Protein-arginine omega-N asymmetric methyltransferase activity network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	crebbp	CREB binding protein b. (2500 aa)
	ncoa3	Nuclear receptor coactivator. (1492 aa)
	ncoa2	Nuclear receptor coactivator. (1511 aa)
	prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (528 aa)
	pgr	Progesterone receptor. (704 aa)
	W5MEM1_LEPOC	Sp1 transcription factor. (691 aa)
	W5MG31_LEPOC	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (584 aa)
	nr3c2	Nuclear receptor subfamily 3, group C, member 2. (987 aa)
	esr2	Estrogen receptor 2a. (571 aa)
	nr3c1	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (786 aa)
	W5N0P4_LEPOC	E1A binding protein p300 a. (2068 aa)
	W5N1I2_LEPOC	Helicase ATP-binding domain-containing protein. (125 aa)
	LOC102694859	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
	ar	Androgen receptor. (859 aa)
	LOC102692415	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (397 aa)
	fkbp4	Peptidylprolyl isomerase. (457 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102692415	LOC102694859	ENSLOCP00000020823	ENSLOCP00000015449	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.754
LOC102692415	W5MG31_LEPOC	ENSLOCP00000020823	ENSLOCP00000007340	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.754
LOC102692415	W5N0P4_LEPOC	ENSLOCP00000020823	ENSLOCP00000014203	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	E1A binding protein p300 a.	0.847
LOC102692415	W5N1I2_LEPOC	ENSLOCP00000020823	ENSLOCP00000014491	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase ATP-binding domain-containing protein.	0.761
LOC102692415	ar	ENSLOCP00000020823	ENSLOCP00000018074	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Androgen receptor.	0.406
LOC102692415	crebbp	ENSLOCP00000020823	ENSLOCP00000003190	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	CREB binding protein b.	0.791
LOC102692415	esr2	ENSLOCP00000020823	ENSLOCP00000012625	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor 2a.	0.732
LOC102692415	ncoa2	ENSLOCP00000020823	ENSLOCP00000004912	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.598
LOC102692415	ncoa3	ENSLOCP00000020823	ENSLOCP00000004775	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.598
LOC102692415	prmt3	ENSLOCP00000020823	ENSLOCP00000005920	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.410
LOC102692415	tp53	ENSLOCP00000020823	ENSLOCP00000017063	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.530
LOC102694859	LOC102692415	ENSLOCP00000015449	ENSLOCP00000020823	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.754
LOC102694859	W5MEM1_LEPOC	ENSLOCP00000015449	ENSLOCP00000006830	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Sp1 transcription factor.	0.799
LOC102694859	W5N0P4_LEPOC	ENSLOCP00000015449	ENSLOCP00000014203	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	E1A binding protein p300 a.	0.922
LOC102694859	W5N1I2_LEPOC	ENSLOCP00000015449	ENSLOCP00000014491	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase ATP-binding domain-containing protein.	0.605
LOC102694859	ar	ENSLOCP00000015449	ENSLOCP00000018074	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Androgen receptor.	0.451
LOC102694859	crebbp	ENSLOCP00000015449	ENSLOCP00000003190	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	CREB binding protein b.	0.886
LOC102694859	esr2	ENSLOCP00000015449	ENSLOCP00000012625	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor 2a.	0.840
LOC102694859	ncoa2	ENSLOCP00000015449	ENSLOCP00000004912	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.769
LOC102694859	ncoa3	ENSLOCP00000015449	ENSLOCP00000004775	Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.769