(23 nodes) Mixed, incl. CORVET complex, and Clathrin, heavy chain/VPS, 7-fold repeat network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vps16	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (838 aa)
	vps33a	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family. (600 aa)
	vps11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (945 aa)
	rab5a	RAB5A, member RAS oncogene family, b. (216 aa)
	ccz1	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. (518 aa)
	vps45	Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (572 aa)
	tgfbrap1	Transforming growth factor, beta receptor associated protein 1. (863 aa)
	W5MTM9_LEPOC	VPS8 subunit of CORVET complex. (1343 aa)
	mon1a	MON1 secretory trafficking family member A. (525 aa)
	rbsn	Rabenosyn, RAB effector. (784 aa)
	vps41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (855 aa)
	LOC107078254	Uncharacterized protein. (1431 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (979 aa)
	vipas39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (493 aa)
	vps39	VPS39 subunit of HOPS complex. (893 aa)
	vps33b	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family. (615 aa)
	mon1b	MON1 secretory trafficking family member Bb. (623 aa)
	W5NB61_LEPOC	GRIP1 associated protein 1. (868 aa)
	rab7a	RAB7A, member RAS oncogene family. (208 aa)
	W5NK12_LEPOC	Si:ch211-266g18.9. (833 aa)
	rab9a	RAB9A, member RAS oncogene family. (201 aa)
	rab9b	RAB9B, member RAS oncogene family. (203 aa)
	W5NP94_LEPOC	RAB9B, member RAS oncogene family. (203 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107078254	W5MTM9_LEPOC	ENSLOCP00000014100	ENSLOCP00000011738	Uncharacterized protein.	VPS8 subunit of CORVET complex.	0.557
LOC107078254	W5NK12_LEPOC	ENSLOCP00000014100	ENSLOCP00000020971	Uncharacterized protein.	Si:ch211-266g18.9.	0.862
LOC107078254	ccz1	ENSLOCP00000014100	ENSLOCP00000010388	Uncharacterized protein.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.456
LOC107078254	rab5a	ENSLOCP00000014100	ENSLOCP00000007962	Uncharacterized protein.	RAB5A, member RAS oncogene family, b.	0.622
LOC107078254	rbsn	ENSLOCP00000014100	ENSLOCP00000013743	Uncharacterized protein.	Rabenosyn, RAB effector.	0.446
LOC107078254	tgfbrap1	ENSLOCP00000014100	ENSLOCP00000010637	Uncharacterized protein.	Transforming growth factor, beta receptor associated protein 1.	0.891
LOC107078254	vps11	ENSLOCP00000014100	ENSLOCP00000006888	Uncharacterized protein.	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.	0.979
LOC107078254	vps16	ENSLOCP00000014100	ENSLOCP00000006408	Uncharacterized protein.	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.	0.979
LOC107078254	vps18	ENSLOCP00000014100	ENSLOCP00000015165	Uncharacterized protein.	VPS18 core subunit of CORVET and HOPS complexes.	0.979
LOC107078254	vps33a	ENSLOCP00000014100	ENSLOCP00000006460	Uncharacterized protein.	VPS33A core subunit of CORVET and HOPS complexes; Belongs to the STXBP/unc-18/SEC1 family.	0.881
LOC107078254	vps33b	ENSLOCP00000014100	ENSLOCP00000017422	Uncharacterized protein.	VPS33B late endosome and lysosome associated; Belongs to the STXBP/unc-18/SEC1 family.	0.877
LOC107078254	vps39	ENSLOCP00000014100	ENSLOCP00000016431	Uncharacterized protein.	VPS39 subunit of HOPS complex.	0.879
LOC107078254	vps41	ENSLOCP00000014100	ENSLOCP00000013941	Uncharacterized protein.	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.	0.821
LOC107078254	vps45	ENSLOCP00000014100	ENSLOCP00000010427	Uncharacterized protein.	Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family.	0.475
W5MTM9_LEPOC	LOC107078254	ENSLOCP00000011738	ENSLOCP00000014100	VPS8 subunit of CORVET complex.	Uncharacterized protein.	0.557
W5MTM9_LEPOC	W5NK12_LEPOC	ENSLOCP00000011738	ENSLOCP00000020971	VPS8 subunit of CORVET complex.	Si:ch211-266g18.9.	0.862
W5MTM9_LEPOC	ccz1	ENSLOCP00000011738	ENSLOCP00000010388	VPS8 subunit of CORVET complex.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.456
W5MTM9_LEPOC	rab5a	ENSLOCP00000011738	ENSLOCP00000007962	VPS8 subunit of CORVET complex.	RAB5A, member RAS oncogene family, b.	0.622
W5MTM9_LEPOC	rbsn	ENSLOCP00000011738	ENSLOCP00000013743	VPS8 subunit of CORVET complex.	Rabenosyn, RAB effector.	0.446
W5MTM9_LEPOC	tgfbrap1	ENSLOCP00000011738	ENSLOCP00000010637	VPS8 subunit of CORVET complex.	Transforming growth factor, beta receptor associated protein 1.	0.891