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| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa) |
| | W5M6I9_LEPOC | Snf2-related CREBBP activator protein. (2439 aa) |
| | spo11 | SPO11 initiator of meiotic double stranded breaks. (391 aa) |
| | LOC102697006 | SIN3-HDAC complex associated factor, like. (217 aa) |
| | smc4 | Structural maintenance of chromosomes protein. (1300 aa) |
| | rcc1 | Regulator of chromosome condensation 1. (421 aa) |
| | W5M8B8_LEPOC | Uncharacterized protein. (326 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa) |
| | RSPH1 | Radial spoke head component 1. (286 aa) |
| | timeless | Timeless circadian clock. (1225 aa) |
| | mcrs1 | Microspherule protein 1. (469 aa) |
| | SETX | Senataxin. (2398 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (760 aa) |
| | phf12 | PHD finger protein 12a. (1018 aa) |
| | W5MCA8_LEPOC | Nucleolar protein 6. (1105 aa) |
| | ino80c | INO80 complex subunit C. (219 aa) |
| | sap130 | Sin3A-associated protein a. (1060 aa) |
| | orc6 | Origin recognition complex, subunit 6. (256 aa) |
| | W5ME26_LEPOC | Uncharacterized protein. (198 aa) |
| | NUFIP1 | Nuclear FMR1 interacting protein 1. (514 aa) |
| | tonsl | Tonsoku-like, DNA repair protein. (1444 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (678 aa) |
| | W5MFX5_LEPOC | HORMA domain-containing protein. (173 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (961 aa) |
| | ep400 | E1A binding protein p400. (3152 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (492 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | smarcb1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (387 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (290 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa) |
| | W5M2C1_LEPOC | DEAH (Asp-Glu-Ala-His) box helicase 9. (1268 aa) |
| | pola1 | DNA polymerase. (1486 aa) |
| | lrwd1 | Leucine-rich repeats and WD repeat domain containing 1. (743 aa) |
| | kifap3 | Kinesin-associated protein 3b. (796 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa) |
| | W5M0N9_LEPOC | Zinc finger, RAN-binding domain containing 3. (1142 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | W5LYW4_LEPOC | Nuclear factor related to kappaB binding protein. (1305 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | fkbp6 | Peptidylprolyl isomerase. (332 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (819 aa) |
| | W5LXJ3_LEPOC | DNA_pol_B domain-containing protein. (97 aa) |
| | sin3b | SIN3 transcription regulator family member B. (1155 aa) |
| | W5LV53_LEPOC | Uncharacterized protein. (149 aa) |
| | W5ND19_LEPOC | SIN3 transcription regulator family member Aa. (1321 aa) |
| | SYCP2L | Synaptonemal complex protein 2 like. (777 aa) |
| | LOC102696624 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) |
| | LOC102695737 | DNA helicase; Belongs to the MCM family. (834 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (225 aa) |
| | smc2 | Structural maintenance of chromosomes protein. (1202 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (887 aa) |
| | znhit1 | Zinc finger, HIT-type containing 1. (154 aa) |
| | W5N869_LEPOC | SET domain containing 5. (1554 aa) |
| | atrx | ATRX chromatin remodeler, like. (2427 aa) |
| | W5N8X8_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (323 aa) |
| | actr8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (626 aa) |
| | W5NAB2_LEPOC | Uncharacterized protein. (116 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa) |
| | actr6 | Actin related protein 6; Belongs to the actin family. (396 aa) |
| | blm | BLM RecQ like helicase. (1481 aa) |
| | ruvbl1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (270 aa) |
| | W5NCA9_LEPOC | SMC_N domain-containing protein. (150 aa) |
| | W5NCB0_LEPOC | Uncharacterized protein. (121 aa) |
| | W5NCB3_LEPOC | Uncharacterized protein. (150 aa) |
| | LOC102697986 | DNA helicase; Belongs to the MCM family. (814 aa) |
| | ino80 | INO80 complex ATPase subunit. (1554 aa) |
| | smc3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | helb | Helicase (DNA) B. (1126 aa) |
| | W5NH47_LEPOC | Cleavage and polyadenylation specific factor 6. (583 aa) |
| | nek2 | NIMA-related kinase 2. (437 aa) |
| | W5NHZ7_LEPOC | Leucine-rich pentatricopeptide repeat containing. (1473 aa) |
| | pinx1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (348 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (196 aa) |
| | W5NJV2_LEPOC | Meiosis-specific, MEI4 homolog (S. cerevisiae). (372 aa) |
| | W5NJX2_LEPOC | Origin recognition complex, subunit 3. (728 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (512 aa) |
| | W5NKF9_LEPOC | Structural maintenance of chromosomes protein. (1233 aa) |
| | mms22l | MMS22-like, DNA repair protein. (1238 aa) |
| | rrs1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (342 aa) |
| | psmc3ip | PSMC3 interacting protein. (214 aa) |
| | sirt7 | Sirtuin 7. (437 aa) |
| | W5NG96_LEPOC | DNA helicase; Belongs to the MCM family. (815 aa) |
| | ing3 | Inhibitor of growth protein. (418 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (867 aa) |
| | W5NEJ9_LEPOC | Lysine (K)-specific methyltransferase 2E. (1307 aa) |
| | W5NEJ3_LEPOC | Origin recognition complex, subunit 5. (375 aa) |
| | LOC102689238 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (763 aa) |
| | tex11 | Testis expressed 11. (922 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) |
| | ino80b | INO80 complex subunit B. (329 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa) |
| | W5N674_LEPOC | Uncharacterized protein. (277 aa) |
| | ruvbl2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) |
| | W5M4D7_LEPOC | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1669 aa) |
| | W5M4G9_LEPOC | DNA_pol_E_B domain-containing protein. (66 aa) |
| | W5M4H6_LEPOC | DNA methyltransferase 1 associated protein 1. (430 aa) |
| | W5M4I8_LEPOC | Uncharacterized protein. (168 aa) |
| | W5M585_LEPOC | Uncharacterized protein. (715 aa) |
| | suds3 | SDS3 homolog, SIN3A corepressor complex component. (319 aa) |
| | ncapg | Non-SMC condensin I complex, subunit G. (1039 aa) |
| | W5N2L8_LEPOC | WD repeat and HMG-box DNA binding protein 1. (1133 aa) |
| | W5M6C2_LEPOC | Uncharacterized protein. (318 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | uchl5 | Ubiquitin carboxyl-terminal hydrolase. (330 aa) |
| | W5ML00_LEPOC | Cell division cycle associated 7a. (393 aa) |
| | W5MNA9_LEPOC | Pre-mRNA processing factor 19. (465 aa) |
| | W5MNK3_LEPOC | Tower domain-containing protein. (871 aa) |
| | W5MNX2_LEPOC | Uncharacterized protein. (298 aa) |
| | wapl | WAPL cohesin release factor a. (1204 aa) |
| | W5MP54_LEPOC | Synaptonemal complex central element protein 2. (141 aa) |
| | W5MPK4_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (151 aa) |
| | anp32e | Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E. (256 aa) |
| | W5MQE4_LEPOC | Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3821 aa) |
| | brms1l | BRMS1 like transcriptional repressor b. (327 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1505 aa) |
| | LOC102698545 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (377 aa) |
| | W5MTP9_LEPOC | Bromodomain containing 8. (859 aa) |
| | smarcal1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (841 aa) |
| | W5MU76_LEPOC | Si:ch211-241j8.2. (465 aa) |
| | orc2 | Origin recognition complex, subunit 2. (576 aa) |
| | LOC102691803 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | W5MWS0_LEPOC | MutL homolog 3 (E. coli). (1078 aa) |
| | W5MXE6_LEPOC | Uncharacterized protein. (199 aa) |
| | W5MY44_LEPOC | INO80 complex subunit Db. (1052 aa) |
| | W5MYF7_LEPOC | RING-type domain-containing protein. (121 aa) |
| | smchd1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (2034 aa) |
| | rpa3 | Replication protein A3. (121 aa) |
| | ino80e | INO80 complex subunit E. (242 aa) |
| | W5MZK1_LEPOC | MutS homolog 4. (840 aa) |
| | W5N048_LEPOC | Uncharacterized protein. (1423 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | lrif1 | Uncharacterized protein. (904 aa) |
| | LOC102683235 | Synaptonemal complex protein 3. (183 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | dmc1 | Uncharacterized protein. (94 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1514 aa) |
