STRINGSTRING
mcm6 mcm6 W5LZH0_LEPOC W5LZH0_LEPOC ighmbp2 ighmbp2 W5M0N9_LEPOC W5M0N9_LEPOC RBBP8 RBBP8 cdc45 cdc45 pola1 pola1 rad51d rad51d ssbp2 ssbp2 dhx36 dhx36 W5M2C1_LEPOC W5M2C1_LEPOC tsn tsn W5M2K4_LEPOC W5M2K4_LEPOC W5M585_LEPOC W5M585_LEPOC lonp1 lonp1 ssbp3 ssbp3 rexo4 rexo4 smc4 smc4 W5MA42_LEPOC W5MA42_LEPOC W5MA78_LEPOC W5MA78_LEPOC top1 top1 nabp2 nabp2 top3a top3a meiob meiob W5MCR9_LEPOC W5MCR9_LEPOC W5MDS3_LEPOC W5MDS3_LEPOC W5MEG5_LEPOC W5MEG5_LEPOC tdp2 tdp2 mcm4 mcm4 ercc1 ercc1 W5MH71_LEPOC W5MH71_LEPOC rpa1 rpa1 nup35 nup35 recql4 recql4 ercc4 ercc4 swsap1 swsap1 W5MNK3_LEPOC W5MNK3_LEPOC bivm bivm polr2h polr2h tdp1 tdp1 smarcal1 smarcal1 wdr48 wdr48 W5MVA4_LEPOC W5MVA4_LEPOC rad50 rad50 rad18 rad18 LOC102698683 LOC102698683 rpa3 rpa3 dmc1 dmc1 stn1 stn1 hrob hrob LOC102697986 LOC102697986 RNF138 RNF138 twnk twnk rad51 rad51 W5N634_LEPOC W5N634_LEPOC mcm7 mcm7 myef2 myef2 W5N6W0_LEPOC W5N6W0_LEPOC LOC102695737 LOC102695737 smc2 smc2 W5N7V0_LEPOC W5N7V0_LEPOC W5N7V5_LEPOC W5N7V5_LEPOC mcm2 mcm2 neil3 neil3 rad51b rad51b LOC102697928 LOC102697928 blm blm hmces hmces W5NC42_LEPOC W5NC42_LEPOC W5NE81_LEPOC W5NE81_LEPOC W5NF63_LEPOC W5NF63_LEPOC mcm10 mcm10 W5NFJ7_LEPOC W5NFJ7_LEPOC W5NFW0_LEPOC W5NFW0_LEPOC W5NG96_LEPOC W5NG96_LEPOC msh2 msh2 W5NHZ7_LEPOC W5NHZ7_LEPOC mcm8 mcm8 W5NK63_LEPOC W5NK63_LEPOC W5NK64_LEPOC W5NK64_LEPOC mms22l mms22l W5NKI1_LEPOC W5NKI1_LEPOC mcm9 mcm9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
W5LZH0_LEPOCHTH myb-type domain-containing protein. (575 aa)
ighmbp2Immunoglobulin mu DNA binding protein 2. (984 aa)
W5M0N9_LEPOCZinc finger, RAN-binding domain containing 3. (1142 aa)
RBBP8Uncharacterized protein. (865 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
pola1DNA polymerase. (1486 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (336 aa)
ssbp2Single-stranded DNA binding protein 2. (387 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1019 aa)
W5M2C1_LEPOCDEAH (Asp-Glu-Ala-His) box helicase 9. (1268 aa)
tsnTranslin. (230 aa)
W5M2K4_LEPOCDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (763 aa)
W5M585_LEPOCUncharacterized protein. (715 aa)
lonp1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1002 aa)
ssbp3LisH domain-containing protein. (389 aa)
rexo4REX4 homolog, 3'-5' exonuclease. (436 aa)
smc4Structural maintenance of chromosomes protein. (1300 aa)
W5MA42_LEPOCSAM domain and HD domain 1. (617 aa)
W5MA78_LEPOCHD domain-containing protein. (411 aa)
top1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (759 aa)
nabp2Nucleic acid binding protein 2. (206 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
W5MCR9_LEPOCNucleic acid binding protein 1a. (223 aa)
W5MDS3_LEPOCFar upstream element (FUSE) binding protein 3. (585 aa)
W5MEG5_LEPOCZgc:110158. (391 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (279 aa)
mcm4DNA helicase; Belongs to the MCM family. (678 aa)
ercc1Excision repair cross-complementation group 1. (418 aa)
W5MH71_LEPOCRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (520 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
nup35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (315 aa)
recql4RecQ helicase-like 4. (1459 aa)
ercc4Excision repair cross-complementation group 4. (637 aa)
swsap1SWIM-type zinc finger 7 associated protein 1. (279 aa)
W5MNK3_LEPOCTower domain-containing protein. (871 aa)
bivmBasic, immunoglobulin-like variable motif containing. (512 aa)
polr2hInfo polymerase (RNA) II (DNA directed) polypeptide H. (112 aa)
tdp1Tyrosyl-DNA phosphodiesterase 1. (611 aa)
smarcal1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (841 aa)
wdr48WD repeat domain 48b. (679 aa)
W5MVA4_LEPOCExcision repair cross-complementation group 5. (1082 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
rad18RAD18 E3 ubiquitin protein ligase. (460 aa)
LOC102698683SET domain and mariner transposase fusion gene. (296 aa)
rpa3Replication protein A3. (121 aa)
dmc1Uncharacterized protein. (94 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (377 aa)
hrobUncharacterized protein. (685 aa)
LOC102697986DNA helicase; Belongs to the MCM family. (814 aa)
RNF138Ring finger protein 138. (239 aa)
twnkTwinkle mtDNA helicase. (699 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
W5N634_LEPOCXeroderma pigmentosum, complementation group C. (927 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa)
myef2Myelin expression factor 2. (604 aa)
W5N6W0_LEPOCRTF1 homolog, Paf1/RNA polymerase II complex component. (707 aa)
LOC102695737DNA helicase; Belongs to the MCM family. (834 aa)
smc2Structural maintenance of chromosomes protein. (1202 aa)
W5N7V0_LEPOCUncharacterized protein. (579 aa)
W5N7V5_LEPOCUncharacterized protein. (157 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
neil3Nei-like DNA glycosylase 3. (579 aa)
rad51bRAD51 paralog B. (384 aa)
LOC102697928Si:ch73-71d17.2. (834 aa)
blmBLM RecQ like helicase. (1481 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (368 aa)
W5NC42_LEPOCRPA1 related single stranded DNA binding protein. (851 aa)
W5NE81_LEPOCATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (636 aa)
W5NF63_LEPOCF-box DNA helicase 1. (1007 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (867 aa)
W5NFJ7_LEPOCSprT-like N-terminal domain. (603 aa)
W5NFW0_LEPOCProtection of telomeres 1 homolog. (774 aa)
W5NG96_LEPOCDNA helicase; Belongs to the MCM family. (815 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
W5NHZ7_LEPOCLeucine-rich pentatricopeptide repeat containing. (1473 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
W5NK63_LEPOCUncharacterized protein. (163 aa)
W5NK64_LEPOCUncharacterized protein. (133 aa)
mms22lMMS22-like, DNA repair protein. (1238 aa)
W5NKI1_LEPOCSingle-stranded DNA binding protein 1. (76 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (660 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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