12 items (Lepisosteus oculatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	W5NFW0_LEPOC	Protection of telomeres 1 homolog. (774 aa)
	W5M613_LEPOC	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (842 aa)
	W5M709_LEPOC	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1056 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	LOC107080026	Uncharacterized protein. (628 aa)
	W5MKE7_LEPOC	Prostaglandin E synthase 3b (cytosolic). (146 aa)
	nhp2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	GAR1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (234 aa)
	W5N7F3_LEPOC	WD repeat containing, antisense to TP53. (422 aa)
	W5N8G8_LEPOC	Dyskeratosis congenita 1, dyskerin. (538 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (348 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GAR1	LOC107080026	ENSLOCP00000014394	ENSLOCP00000008285	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Uncharacterized protein.	0.644
GAR1	W5M709_LEPOC	ENSLOCP00000014394	ENSLOCP00000004167	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.868
GAR1	W5N7F3_LEPOC	ENSLOCP00000014394	ENSLOCP00000016562	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	WD repeat containing, antisense to TP53.	0.988
GAR1	W5N8G8_LEPOC	ENSLOCP00000014394	ENSLOCP00000016927	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Dyskeratosis congenita 1, dyskerin.	0.999
GAR1	W5NFW0_LEPOC	ENSLOCP00000014394	ENSLOCP00000019519	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Protection of telomeres 1 homolog.	0.832
GAR1	nhp2	ENSLOCP00000014394	ENSLOCP00000011776	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.999
GAR1	pinx1	ENSLOCP00000014394	ENSLOCP00000020716	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	PIN2 (TERF1) interacting telomerase inhibitor 1.	0.604
LOC107080026	GAR1	ENSLOCP00000008285	ENSLOCP00000014394	Uncharacterized protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.644
LOC107080026	W5M709_LEPOC	ENSLOCP00000008285	ENSLOCP00000004167	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.978
LOC107080026	W5N7F3_LEPOC	ENSLOCP00000008285	ENSLOCP00000016562	Uncharacterized protein.	WD repeat containing, antisense to TP53.	0.611
LOC107080026	W5N8G8_LEPOC	ENSLOCP00000008285	ENSLOCP00000016927	Uncharacterized protein.	Dyskeratosis congenita 1, dyskerin.	0.664
LOC107080026	W5NFW0_LEPOC	ENSLOCP00000008285	ENSLOCP00000019519	Uncharacterized protein.	Protection of telomeres 1 homolog.	0.996
LOC107080026	nhp2	ENSLOCP00000008285	ENSLOCP00000011776	Uncharacterized protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.660
W5M613_LEPOC	rpa1	ENSLOCP00000003821	ENSLOCP00000007742	TEL2, telomere maintenance 2, homolog (S. cerevisiae).	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.425
W5M709_LEPOC	GAR1	ENSLOCP00000004167	ENSLOCP00000014394	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.868
W5M709_LEPOC	LOC107080026	ENSLOCP00000004167	ENSLOCP00000008285	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	Uncharacterized protein.	0.978
W5M709_LEPOC	W5MKE7_LEPOC	ENSLOCP00000004167	ENSLOCP00000008856	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	Prostaglandin E synthase 3b (cytosolic).	0.752
W5M709_LEPOC	W5N7F3_LEPOC	ENSLOCP00000004167	ENSLOCP00000016562	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	WD repeat containing, antisense to TP53.	0.890
W5M709_LEPOC	W5N8G8_LEPOC	ENSLOCP00000004167	ENSLOCP00000016927	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	Dyskeratosis congenita 1, dyskerin.	0.923
W5M709_LEPOC	W5NFW0_LEPOC	ENSLOCP00000004167	ENSLOCP00000019519	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	Protection of telomeres 1 homolog.	0.985