(42 nodes) Positive regulation of macroautophagy network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sirt1	Sirtuin 1. (720 aa)
	W5LWL6_LEPOC	Uncharacterized protein. (142 aa)
	LOC102698806	Zgc:73226. (182 aa)
	W5LYW5_LEPOC	PUB domain-containing protein. (133 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (944 aa)
	pink1	PTEN induced kinase 1. (581 aa)
	W5M3M5_LEPOC	Leucine rich repeat and sterile alpha motif containing 1. (630 aa)
	snx4	Sorting nexin 4. (462 aa)
	snx30	Sorting nexin family member 30. (435 aa)
	tsc2	TSC complex subunit 2. (1854 aa)
	hspb8	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family. (199 aa)
	vps13d	Vacuolar protein sorting 13 homolog D. (4398 aa)
	wdr24	WD repeat domain 24. (788 aa)
	GPSM1	G protein signaling modulator 1b. (647 aa)
	SESN2	Uncharacterized protein. (536 aa)
	W5ME60_LEPOC	Autophagy/beclin-1 regulator 1a. (1252 aa)
	LOC102697582	TSC complex subunit 1a. (1189 aa)
	LOC102696607	Adhesion G protein-coupled receptor G1. (539 aa)
	bnip3	BCL2 interacting protein 3. (198 aa)
	sesn3	Sestrin 3. (481 aa)
	sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (473 aa)
	W5MNU5_LEPOC	Sorting nexin 7. (467 aa)
	W5MWM5_LEPOC	Receptor-interacting serine-threonine kinase 2. (573 aa)
	W5MWN7_LEPOC	Huntingtin. (3067 aa)
	W5MWV8_LEPOC	Short coiled-coil protein b. (117 aa)
	W5N075_LEPOC	BCL2 associated athanogene 3. (552 aa)
	pip4k2a	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b. (405 aa)
	c9orf72	Zgc:100846. (461 aa)
	W5N311_LEPOC	Si:dkey-181m9.8. (582 aa)
	W5N4B5_LEPOC	Transmembrane protein 173. (329 aa)
	fyco1	FYVE and coiled-coil domain containing 1a. (1540 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (413 aa)
	foxa3	Forkhead box A3. (439 aa)
	LOC102688454	Si:zfos-80g12.1. (443 aa)
	wdr45	WD repeat domain 45. (358 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (318 aa)
	LOC102683252	Decorin; May affect the rate of fibrils formation. (359 aa)
	W5NIQ5_LEPOC	Sestrin 1. (486 aa)
	W5NIQ8_LEPOC	Uncharacterized protein. (129 aa)
	W5NK97_LEPOC	RAB3GAP2_C domain-containing protein. (380 aa)
	W5NK99_LEPOC	RAB3GAP2_C domain-containing protein. (89 aa)
	W5NKA0_LEPOC	Uncharacterized protein. (85 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GPSM1	PIP4K2B	ENSLOCP00000004578	ENSLOCP00000016897	G protein signaling modulator 1b.	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta.	0.424
GPSM1	pip4k2a	ENSLOCP00000004578	ENSLOCP00000014548	G protein signaling modulator 1b.	Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b.	0.424
LOC102688454	SESN2	ENSLOCP00000018363	ENSLOCP00000006147	Si:zfos-80g12.1.	Uncharacterized protein.	0.791
LOC102688454	W5NIQ5_LEPOC	ENSLOCP00000018363	ENSLOCP00000020514	Si:zfos-80g12.1.	Sestrin 1.	0.789
LOC102688454	sesn3	ENSLOCP00000018363	ENSLOCP00000009204	Si:zfos-80g12.1.	Sestrin 3.	0.696
LOC102688454	wdr24	ENSLOCP00000018363	ENSLOCP00000004159	Si:zfos-80g12.1.	WD repeat domain 24.	0.768
LOC102696607	LOC102697582	ENSLOCP00000007220	ENSLOCP00000006922	Adhesion G protein-coupled receptor G1.	TSC complex subunit 1a.	0.485
LOC102696607	W5LWL6_LEPOC	ENSLOCP00000007220	ENSLOCP00000000523	Adhesion G protein-coupled receptor G1.	Uncharacterized protein.	0.751
LOC102696607	W5LYW5_LEPOC	ENSLOCP00000007220	ENSLOCP00000001322	Adhesion G protein-coupled receptor G1.	PUB domain-containing protein.	0.621
LOC102696607	W5MWM5_LEPOC	ENSLOCP00000007220	ENSLOCP00000012784	Adhesion G protein-coupled receptor G1.	Receptor-interacting serine-threonine kinase 2.	0.862
LOC102696607	W5MWN7_LEPOC	ENSLOCP00000007220	ENSLOCP00000012796	Adhesion G protein-coupled receptor G1.	Huntingtin.	0.577
LOC102696607	W5N075_LEPOC	ENSLOCP00000007220	ENSLOCP00000014034	Adhesion G protein-coupled receptor G1.	BCL2 associated athanogene 3.	0.502
LOC102696607	W5N311_LEPOC	ENSLOCP00000007220	ENSLOCP00000015020	Adhesion G protein-coupled receptor G1.	Si:dkey-181m9.8.	0.876
LOC102696607	W5N4B5_LEPOC	ENSLOCP00000007220	ENSLOCP00000015474	Adhesion G protein-coupled receptor G1.	Transmembrane protein 173.	0.478
LOC102696607	nod1	ENSLOCP00000007220	ENSLOCP00000002219	Adhesion G protein-coupled receptor G1.	Nucleotide-binding oligomerization domain containing 1.	0.966
LOC102697582	LOC102696607	ENSLOCP00000006922	ENSLOCP00000007220	TSC complex subunit 1a.	Adhesion G protein-coupled receptor G1.	0.485
LOC102697582	W5MWM5_LEPOC	ENSLOCP00000006922	ENSLOCP00000012784	TSC complex subunit 1a.	Receptor-interacting serine-threonine kinase 2.	0.485
LOC102697582	W5N075_LEPOC	ENSLOCP00000006922	ENSLOCP00000014034	TSC complex subunit 1a.	BCL2 associated athanogene 3.	0.427
LOC102697582	hspb8	ENSLOCP00000006922	ENSLOCP00000003791	TSC complex subunit 1a.	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.	0.455
LOC102697582	pink1	ENSLOCP00000006922	ENSLOCP00000002266	TSC complex subunit 1a.	PTEN induced kinase 1.	0.552