(60 nodes) Nuclear receptor binding network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5LXZ7_LEPOC	Nuclear receptor interacting protein 1b. (1137 aa)
	W5M3F8_LEPOC	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (186 aa)
	W5M717_LEPOC	Nuclear receptor corepressor 1. (2336 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1041 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2b. (266 aa)
	ncoa3	Nuclear receptor coactivator. (1492 aa)
	ncoa2	Nuclear receptor coactivator. (1511 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (859 aa)
	W5MAF8_LEPOC	Nuclear receptor coactivator 6. (1916 aa)
	W5MAH5_LEPOC	Nuclear receptor subfamily 4, group A, member 1. (608 aa)
	prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (995 aa)
	bud31	BUD31 homolog. (146 aa)
	gtf2b	General transcription factor IIB. (316 aa)
	bcas3	BCAS3 microtubule associated cell migration factor. (814 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (682 aa)
	W5MDV9_LEPOC	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (689 aa)
	CCDC62	Coiled-coil domain containing 62. (405 aa)
	NR4A2	Nuclear receptor subfamily 4, group A, member 2b. (595 aa)
	W5MFZ2_LEPOC	Nuclear receptor corepressor 2. (2440 aa)
	cnot1	CCR4-NOT transcription complex, subunit 1. (2376 aa)
	W5MH03_LEPOC	Nuclear receptor subfamily 1, group H, member 3. (280 aa)
	LOC107075828	BSD domain-containing protein. (170 aa)
	nrbf2	Nuclear receptor binding factor 2b. (269 aa)
	ppid	Peptidylprolyl isomerase D. (371 aa)
	ddx54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (851 aa)
	W5MQQ5_LEPOC	TACC_C domain-containing protein. (1022 aa)
	W5MQR5_LEPOC	SNW domain containing 1. (535 aa)
	LOC102683760	Nuclear receptor subfamily 0, group B, member 1. (261 aa)
	dcaf13	Ddb1 and cul4 associated factor 13. (455 aa)
	W5MTP9_LEPOC	Bromodomain containing 8. (859 aa)
	hmga1	High mobility group AT-hook 1a. (100 aa)
	tmf1	TATA element modulatory factor 1. (1140 aa)
	LOC102686811	Uncharacterized protein. (512 aa)
	prmt2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (417 aa)
	rnf14	RBR-type E3 ubiquitin transferase. (462 aa)
	znf366	Zinc finger protein 366. (741 aa)
	sirt1	Sirtuin 1. (720 aa)
	lrif1	Uncharacterized protein. (904 aa)
	W5N0P4_LEPOC	E1A binding protein p300 a. (2068 aa)
	LOC102685659	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (814 aa)
	W5N399_LEPOC	Uncharacterized protein. (165 aa)
	lef1	Lymphoid enhancer-binding factor 1. (397 aa)
	W5N3A3_LEPOC	Uncharacterized protein. (261 aa)
	W5N3A8_LEPOC	PWWP domain-containing protein. (405 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (833 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1734 aa)
	dnaaf4	Dynein axonemal assembly factor 4. (407 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1511 aa)
	W5N7Y1_LEPOC	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (423 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (580 aa)
	trip4	Thyroid hormone receptor interactor 4. (577 aa)
	nkx3-1	NK3 homeobox 1. (220 aa)
	LOC102693337	ARID domain-containing protein. (585 aa)
	tacc1	Transforming, acidic coiled-coil containing protein 1. (786 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	taf7l	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (371 aa)
	ncoa1	Nuclear receptor coactivator 1. (1413 aa)
	grip1	Glutamate receptor interacting protein 1. (1157 aa)
	TRERF1	Transcriptional regulating factor 1. (1219 aa)
	LOC102696687	Uncharacterized protein. (121 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102683760	NR4A2	ENSLOCP00000011386	ENSLOCP00000006932	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor subfamily 4, group A, member 2b.	0.441
LOC102683760	W5LXZ7_LEPOC	ENSLOCP00000011386	ENSLOCP00000001004	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor interacting protein 1b.	0.586
LOC102683760	W5M717_LEPOC	ENSLOCP00000011386	ENSLOCP00000004175	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor corepressor 1.	0.746
LOC102683760	W5MAH5_LEPOC	ENSLOCP00000011386	ENSLOCP00000005384	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor subfamily 4, group A, member 1.	0.441
LOC102683760	W5MFZ2_LEPOC	ENSLOCP00000011386	ENSLOCP00000007301	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor corepressor 2.	0.746
LOC102683760	W5N0P4_LEPOC	ENSLOCP00000011386	ENSLOCP00000014203	Nuclear receptor subfamily 0, group B, member 1.	E1A binding protein p300 a.	0.434
LOC102683760	W5N7Y1_LEPOC	ENSLOCP00000011386	ENSLOCP00000016740	Nuclear receptor subfamily 0, group B, member 1.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1.	0.470
LOC102683760	med1	ENSLOCP00000011386	ENSLOCP00000015717	Nuclear receptor subfamily 0, group B, member 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.723
LOC102683760	ncoa1	ENSLOCP00000011386	ENSLOCP00000019570	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor coactivator 1.	0.496
LOC102683760	ncoa2	ENSLOCP00000011386	ENSLOCP00000004912	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor coactivator.	0.538
LOC102683760	ncoa3	ENSLOCP00000011386	ENSLOCP00000004775	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor coactivator.	0.496
LOC102683760	nr4a3	ENSLOCP00000011386	ENSLOCP00000006467	Nuclear receptor subfamily 0, group B, member 1.	Nuclear receptor subfamily 4, group A, member 3.	0.441
LOC102683760	ppargc1a	ENSLOCP00000011386	ENSLOCP00000015207	Nuclear receptor subfamily 0, group B, member 1.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.483
LOC102685659	W5MH03_LEPOC	ENSLOCP00000014998	ENSLOCP00000007662	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta.	Nuclear receptor subfamily 1, group H, member 3.	0.412
LOC102686811	NR4A2	ENSLOCP00000012738	ENSLOCP00000006932	Uncharacterized protein.	Nuclear receptor subfamily 4, group A, member 2b.	0.438
LOC102686811	W5LXZ7_LEPOC	ENSLOCP00000012738	ENSLOCP00000001004	Uncharacterized protein.	Nuclear receptor interacting protein 1b.	0.472
LOC102686811	W5M717_LEPOC	ENSLOCP00000012738	ENSLOCP00000004175	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.876
LOC102686811	W5MAH5_LEPOC	ENSLOCP00000012738	ENSLOCP00000005384	Uncharacterized protein.	Nuclear receptor subfamily 4, group A, member 1.	0.438
LOC102686811	W5MFZ2_LEPOC	ENSLOCP00000012738	ENSLOCP00000007301	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.876
LOC102686811	W5N0P4_LEPOC	ENSLOCP00000012738	ENSLOCP00000014203	Uncharacterized protein.	E1A binding protein p300 a.	0.619