(79 nodes) Regulation of TOR signaling network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5MY75_LEPOC	Solute carrier family 38 member 9. (536 aa)
	W5LXQ6_LEPOC	Uncharacterized protein. (228 aa)
	tti1	TELO2 interacting protein 1. (1072 aa)
	W5LZK6_LEPOC	Non-specific serine/threonine protein kinase. (3061 aa)
	LOC107079724	Uncharacterized protein. (315 aa)
	W5LZN7_LEPOC	Uncharacterized protein. (337 aa)
	W5LZS7_LEPOC	WD repeat domain 59. (990 aa)
	castor2	Cytosolic arginine sensor for mTORC1 subunit 2. (329 aa)
	naa35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit. (724 aa)
	W5M4F7_LEPOC	DEP domain containing 5. (622 aa)
	LOC102696535	Si:dkeyp-97e7.9. (417 aa)
	tsc2	TSC complex subunit 2. (1854 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (373 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (326 aa)
	wdr24	WD repeat domain 24. (788 aa)
	W5M8T8_LEPOC	Tumor necrosis factor, alpha-induced protein 8-like 1. (202 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3760 aa)
	fam83d	Family with sequence similarity 83 member D. (567 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
	SESN2	Uncharacterized protein. (536 aa)
	ddit4	DNA-damage-inducible transcript 4. (229 aa)
	LOC102697582	TSC complex subunit 1a. (1189 aa)
	rragc	Ras-related GTP binding Ca. (380 aa)
	clec16a	C-type lectin domain containing 16A. (1043 aa)
	W5MH50_LEPOC	Glucosylceramidase. (201 aa)
	klhl22	Kelch-like family member 22. (631 aa)
	golph3	Golgi phosphoprotein 3. (295 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (420 aa)
	wac	WW domain containing adaptor with coiled-coil a. (657 aa)
	htr6	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	sesn3	Sestrin 3. (481 aa)
	nprl3	NPR3-like, GATOR1 complex subunit. (594 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (164 aa)
	LOC102698566	Uncharacterized protein. (421 aa)
	W5MQB6_LEPOC	PKD domain-containing protein. (278 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (551 aa)
	lamtor2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
	deptor	DEP domain containing MTOR-interacting protein. (413 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (421 aa)
	gas6	Uncharacterized protein. (702 aa)
	fnip1	Folliculin interacting protein 1. (1178 aa)
	sh3bp4	SH3-domain binding protein 4. (966 aa)
	W5MWP8_LEPOC	Leucyl-tRNA synthetase b; Belongs to the class-I aminoacyl-tRNA synthetase family. (1169 aa)
	mios	Missing oocyte, meiosis regulator, homolog (Drosophila). (877 aa)
	ttc33	Non-specific serine/threonine protein kinase. (561 aa)
	sirt1	Sirtuin 1. (720 aa)
	lamtor3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
	W5N2F4_LEPOC	G protein-coupled receptor 137c. (418 aa)
	DGKQ	Diacylglycerol kinase. (924 aa)
	c9orf72	Zgc:100846. (461 aa)
	rictor	RPTOR independent companion of MTOR, complex 2b. (1705 aa)
	tbck	TBC1 domain containing kinase. (894 aa)
	ift57	Intraflagellar transport 57 homolog (Chlamydomonas). (411 aa)
	minar1	Membrane integral NOTCH2 associated receptor 1. (900 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1725 aa)
	tbc1d7	TBC1 domain family, member 7. (308 aa)
	W5N7F7_LEPOC	Regulatory associated protein of MTOR, complex 1. (1375 aa)
	W5N7S6_LEPOC	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (322 aa)
	W5NA75_LEPOC	NPR2 like, GATOR1 complex subunit. (381 aa)
	W5NAD3_LEPOC	Kaptin (actin binding protein). (441 aa)
	LOC102688454	Si:zfos-80g12.1. (443 aa)
	LOC102690405	Ras-related GTP binding A. (315 aa)
	tmem127	Transmembrane protein 127. (240 aa)
	RELN	Reelin. (3138 aa)
	LOC102698487	Leptin a. (172 aa)
	gpr137b	G protein-coupled receptor 137Bb. (444 aa)
	W5NFZ6_LEPOC	Intraflagellar transport 172. (1751 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (408 aa)
	W5NG59_LEPOC	CBM21 domain-containing protein. (1012 aa)
	ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1786 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (434 aa)
	W5NIQ5_LEPOC	Sestrin 1. (486 aa)
	W5NIQ8_LEPOC	Uncharacterized protein. (129 aa)
	W5NJC4_LEPOC	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (99 aa)
	fbxo9	F-box protein 9. (426 aa)
	clg8h12orf66	Si:ch211-125a15.1. (448 aa)
	W5NNQ4_LEPOC	Ring finger protein 152. (115 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMT2	LOC102690405	ENSLOCP00000019617	ENSLOCP00000018442	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Ras-related GTP binding A.	0.575
BMT2	LOC107079724	ENSLOCP00000019617	ENSLOCP00000001576	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.684
BMT2	SZT2	ENSLOCP00000019617	ENSLOCP00000005229	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	SZT2 subunit of KICSTOR complex.	0.768
BMT2	W5LZN7_LEPOC	ENSLOCP00000019617	ENSLOCP00000001594	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.684
BMT2	W5M4F7_LEPOC	ENSLOCP00000019617	ENSLOCP00000003265	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain containing 5.	0.684
BMT2	W5N7F7_LEPOC	ENSLOCP00000019617	ENSLOCP00000016566	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Regulatory associated protein of MTOR, complex 1.	0.556
BMT2	W5NA75_LEPOC	ENSLOCP00000019617	ENSLOCP00000017534	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.748
BMT2	W5NAD3_LEPOC	ENSLOCP00000019617	ENSLOCP00000017592	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Kaptin (actin binding protein).	0.719
BMT2	clg8h12orf66	ENSLOCP00000019617	ENSLOCP00000020981	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Si:ch211-125a15.1.	0.854
BMT2	itfg2	ENSLOCP00000019617	ENSLOCP00000020454	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.792
BMT2	lamtor2	ENSLOCP00000019617	ENSLOCP00000010820	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	0.547
BMT2	lamtor3	ENSLOCP00000019617	ENSLOCP00000014385	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3.	0.539
BMT2	lamtor5	ENSLOCP00000019617	ENSLOCP00000014397	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.544
BMT2	nprl3	ENSLOCP00000019617	ENSLOCP00000009367	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR3-like, GATOR1 complex subunit.	0.740
BMT2	rragc	ENSLOCP00000019617	ENSLOCP00000006979	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Ras-related GTP binding Ca.	0.513
CASTOR1	LOC102690405	ENSLOCP00000004153	ENSLOCP00000018442	Cytosolic arginine sensor for mTORC1 subunit 1.	Ras-related GTP binding A.	0.527
CASTOR1	LOC107079724	ENSLOCP00000004153	ENSLOCP00000001576	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.524
CASTOR1	SZT2	ENSLOCP00000004153	ENSLOCP00000005229	Cytosolic arginine sensor for mTORC1 subunit 1.	SZT2 subunit of KICSTOR complex.	0.457
CASTOR1	W5LZN7_LEPOC	ENSLOCP00000004153	ENSLOCP00000001594	Cytosolic arginine sensor for mTORC1 subunit 1.	Uncharacterized protein.	0.524
CASTOR1	W5LZS7_LEPOC	ENSLOCP00000004153	ENSLOCP00000001634	Cytosolic arginine sensor for mTORC1 subunit 1.	WD repeat domain 59.	0.900