(53 nodes) Cellular response to UV network (Lepisosteus oculatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102698741	Mitogen-activated protein kinase. (361 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (280 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (595 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
	rhbdd1	Rhomboid domain containing 1. (331 aa)
	ppid	Peptidylprolyl isomerase D. (371 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa)
	ercc4	Excision repair cross-complementation group 4. (637 aa)
	W5MKH2_LEPOC	Zgc:171687. (279 aa)
	W5MK47_LEPOC	NOC2-like nucleolar associated transcriptional repressor. (773 aa)
	cops9	COP9 signalosome subunit 9. (57 aa)
	impact	Impact RWD domain protein. (327 aa)
	ACTR5	Actin related protein 5; Belongs to the actin family. (492 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (243 aa)
	ercc1	Excision repair cross-complementation group 1. (418 aa)
	W5MDZ8_LEPOC	Polymerase (DNA directed) kappa. (839 aa)
	bax	Zgc:153993. (206 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
	W5MBP3_LEPOC	Transmembrane protein 161A. (478 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (859 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1374 aa)
	crebbp	CREB binding protein b. (2500 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1019 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (445 aa)
	W5LZ20_LEPOC	Melanocyte-stimulating hormone receptor. (330 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	W5LXJ3_LEPOC	DNA_pol_B domain-containing protein. (97 aa)
	LOC102694913	Uncharacterized protein. (319 aa)
	LOC102685390	Mitogen-activated protein kinase. (367 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha a. (316 aa)
	W5NAC3_LEPOC	Hyaluronidase. (429 aa)
	W5NAT1_LEPOC	NTR domain-containing protein. (227 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (864 aa)
	W5NFE6_LEPOC	Polymerase (DNA directed), eta. (645 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1009 aa)
	W5NFQ1_LEPOC	Opsin 8, group member a; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (340 aa)
	opn5	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
	W5LV61_LEPOC	Damage-specific DNA binding protein 1. (1044 aa)
	rhno1	RAD9-HUS1-RAD1 interacting nuclear orphan 1. (290 aa)
	opn3	Opsin 3. (385 aa)
	LOC102691183	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (352 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (697 aa)
	aurkb	Aurora kinase B; Belongs to the protein kinase superfamily. (337 aa)
	W5N634_LEPOC	Xeroderma pigmentosum, complementation group C. (927 aa)
	bmf	Uncharacterized protein. (153 aa)
	W5N4L0_LEPOC	Uncharacterized protein. (303 aa)
	W5N4K6_LEPOC	Uncharacterized protein. (623 aa)
	BAK1	BCL2 antagonist/killer 1. (216 aa)
	ino80	INO80 complex ATPase subunit. (1554 aa)
	W5N0P4_LEPOC	E1A binding protein p300 a. (2068 aa)
	sirt1	Sirtuin 1. (720 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (755 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR5	W5LV61_LEPOC	ENSLOCP00000007736	ENSLOCP00000000018	Actin related protein 5; Belongs to the actin family.	Damage-specific DNA binding protein 1.	0.698
ACTR5	ino80	ENSLOCP00000007736	ENSLOCP00000015157	Actin related protein 5; Belongs to the actin family.	INO80 complex ATPase subunit.	0.995
ACTR5	xpa	ENSLOCP00000007736	ENSLOCP00000011718	Actin related protein 5; Belongs to the actin family.	Xeroderma pigmentosum, complementation group A.	0.504
BAK1	bmf	ENSLOCP00000015556	ENSLOCP00000015606	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.643
BAK1	casp9	ENSLOCP00000015556	ENSLOCP00000002171	BCL2 antagonist/killer 1.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.459
BAK1	sirt1	ENSLOCP00000015556	ENSLOCP00000013852	BCL2 antagonist/killer 1.	Sirtuin 1.	0.477
LOC102685390	casp9	ENSLOCP00000016789	ENSLOCP00000002171	Mitogen-activated protein kinase.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.523
LOC102691183	opn3	ENSLOCP00000020544	ENSLOCP00000020474	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.	Opsin 3.	0.456
LOC102694913	W5LXJ3_LEPOC	ENSLOCP00000000453	ENSLOCP00000000850	Uncharacterized protein.	DNA_pol_B domain-containing protein.	0.563
LOC102694913	W5MBP3_LEPOC	ENSLOCP00000000453	ENSLOCP00000005802	Uncharacterized protein.	Transmembrane protein 161A.	0.424
LOC102694913	casp9	ENSLOCP00000000453	ENSLOCP00000002171	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.401
LOC102698741	casp9	ENSLOCP00000013678	ENSLOCP00000002171	Mitogen-activated protein kinase.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.523
W5LV61_LEPOC	ACTR5	ENSLOCP00000000018	ENSLOCP00000007736	Damage-specific DNA binding protein 1.	Actin related protein 5; Belongs to the actin family.	0.698
W5LV61_LEPOC	W5LXJ3_LEPOC	ENSLOCP00000000018	ENSLOCP00000000850	Damage-specific DNA binding protein 1.	DNA_pol_B domain-containing protein.	0.774
W5LV61_LEPOC	W5MDZ8_LEPOC	ENSLOCP00000000018	ENSLOCP00000006607	Damage-specific DNA binding protein 1.	Polymerase (DNA directed) kappa.	0.474
W5LV61_LEPOC	W5N0P4_LEPOC	ENSLOCP00000000018	ENSLOCP00000014203	Damage-specific DNA binding protein 1.	E1A binding protein p300 a.	0.539
W5LV61_LEPOC	W5N634_LEPOC	ENSLOCP00000000018	ENSLOCP00000016093	Damage-specific DNA binding protein 1.	Xeroderma pigmentosum, complementation group C.	0.878
W5LV61_LEPOC	chek1	ENSLOCP00000000018	ENSLOCP00000001080	Damage-specific DNA binding protein 1.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.827
W5LV61_LEPOC	cul4a	ENSLOCP00000000018	ENSLOCP00000012012	Damage-specific DNA binding protein 1.	Cullin 4A; Belongs to the cullin family.	0.992
W5LV61_LEPOC	cul4b	ENSLOCP00000000018	ENSLOCP00000018769	Damage-specific DNA binding protein 1.	Cullin 4B; Belongs to the cullin family.	0.992