(37 nodes) Organ growth network (Lepisosteus oculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	fxn	Frataxin. (122 aa)
	ostn	Osteocrin. (133 aa)
	nkx2-5	NK2 homeobox 5. (315 aa)
	ube3a	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (899 aa)
	dipk2a	Divergent protein kinase domain 2Aa. (434 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (466 aa)
	LOC102696549	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (378 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (379 aa)
	W5MKA8_LEPOC	Uncharacterized protein. (172 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1786 aa)
	utp25	UTP25 small subunit processor component. (757 aa)
	hey2	Hes-related family bHLH transcription factor with YRPW motif 2. (335 aa)
	W5LXI3_LEPOC	Uncharacterized protein. (355 aa)
	W5LYH0_LEPOC	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (323 aa)
	anxa6	Annexin. (666 aa)
	W5LYX0_LEPOC	Transforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
	W5MIY9_LEPOC	Leptin receptor. (834 aa)
	W5MHU9_LEPOC	SEA domain-containing protein. (281 aa)
	tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
	tbx20	T-box transcription factor 20. (461 aa)
	LOC102692092	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (638 aa)
	ift80	Uncharacterized protein. (948 aa)
	rap1a	RAP1A, member of RAS oncogene family b. (185 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (395 aa)
	EVC	EvC ciliary complex subunit 1. (991 aa)
	adprhl1	ADP-ribosylhydrolase like 1. (357 aa)
	rap1b	RAP1B, member of RAS oncogene family. (185 aa)
	sav1	Salvador family WW domain containing protein 1. (399 aa)
	map2k4	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (428 aa)
	bcl2	BCL2 apoptosis regulator b. (231 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
	ar	Androgen receptor. (859 aa)
	stc1	Stanniocalcin 1, like. (252 aa)
	LOC102698487	Leptin a. (172 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102692092	W5LYX0_LEPOC	ENSLOCP00000003309	ENSLOCP00000001327	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.956
LOC102692092	tgfb2	ENSLOCP00000003309	ENSLOCP00000019603	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.956
LOC102692092	tgfbr2	ENSLOCP00000003309	ENSLOCP00000002712	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.859
LOC102696549	cav1	ENSLOCP00000021983	ENSLOCP00000019204	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.649
LOC102696549	nkx2-5	ENSLOCP00000021983	ENSLOCP00000011169	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.515
LOC102698487	W5MIY9_LEPOC	ENSLOCP00000019129	ENSLOCP00000008348	Leptin a.	Leptin receptor.	0.973
LOC102698487	ar	ENSLOCP00000019129	ENSLOCP00000018074	Leptin a.	Androgen receptor.	0.535
LOC102698487	bcl2	ENSLOCP00000019129	ENSLOCP00000015516	Leptin a.	BCL2 apoptosis regulator b.	0.510
W5LYX0_LEPOC	LOC102692092	ENSLOCP00000001327	ENSLOCP00000003309	Transforming growth factor beta; Belongs to the TGF-beta family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.956
W5LYX0_LEPOC	tgfbr2	ENSLOCP00000001327	ENSLOCP00000002712	Transforming growth factor beta; Belongs to the TGF-beta family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.977
W5MHU9_LEPOC	arid2	ENSLOCP00000007958	ENSLOCP00000020286	SEA domain-containing protein.	AT rich interactive domain 2 (ARID, RFX-like).	0.561
W5MIY9_LEPOC	LOC102698487	ENSLOCP00000008348	ENSLOCP00000019129	Leptin receptor.	Leptin a.	0.973
ar	LOC102698487	ENSLOCP00000018074	ENSLOCP00000019129	Androgen receptor.	Leptin a.	0.535
ar	cav1	ENSLOCP00000018074	ENSLOCP00000019204	Androgen receptor.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.430
ar	ube3a	ENSLOCP00000018074	ENSLOCP00000010189	Androgen receptor.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.430
arid2	W5MHU9_LEPOC	ENSLOCP00000020286	ENSLOCP00000007958	AT rich interactive domain 2 (ARID, RFX-like).	SEA domain-containing protein.	0.561
bcl2	LOC102698487	ENSLOCP00000015516	ENSLOCP00000019129	BCL2 apoptosis regulator b.	Leptin a.	0.510
cav1	LOC102696549	ENSLOCP00000019204	ENSLOCP00000021983	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.649
cav1	ar	ENSLOCP00000019204	ENSLOCP00000018074	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Androgen receptor.	0.430
nkx2-5	LOC102696549	ENSLOCP00000011169	ENSLOCP00000021983	NK2 homeobox 5.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.515