(69 nodes) Glucose homeostasis network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102685225	Hepatocyte nuclear factor 1-beta-A-like. (127 aa)
	W5LW90_LEPOC	Uncharacterized protein. (418 aa)
	W5LZQ9_LEPOC	Methyl-CpG binding domain protein 5. (1749 aa)
	W5M1Q2_LEPOC	Fat storage inducing transmembrane protein 2. (259 aa)
	W5M225_LEPOC	Glucose-6-phosphate isomerase; Belongs to the GPI family. (560 aa)
	W5M494_LEPOC	Zinc finger and BTB domain containing 20. (721 aa)
	W5M5R8_LEPOC	X-box binding protein 1. (385 aa)
	slc37a4	Solute carrier family 37 member 4a. (515 aa)
	park7	Parkinson protein 7. (189 aa)
	znf236	Zinc finger protein 236. (1867 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (260 aa)
	csrp3	Cysteine and glycine-rich protein 3 (cardiac LIM protein). (192 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
	W5MDA1_LEPOC	Si:ch73-90p23.1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	W5MDL8_LEPOC	Si:ch211-231m23.4; Belongs to the G-protein coupled receptor 1 family. (327 aa)
	LOC102692225	Neurotrophin receptor associated death domain. (409 aa)
	yap1	Yes-associated protein 1. (444 aa)
	HNF1B	HNF1 homeobox Bb. (448 aa)
	dhps	Deoxyhypusine synthase. (310 aa)
	W5MGK5_LEPOC	Nuclear receptor subfamily 1, group D, member 4b. (362 aa)
	W5MHU9_LEPOC	SEA domain-containing protein. (281 aa)
	W5MIM9_LEPOC	Nuclear receptor coactivator 5. (693 aa)
	W5MIY9_LEPOC	Leptin receptor. (834 aa)
	LOC102691632	Adiponectin, C1Q and collagen domain containing, b. (266 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (623 aa)
	NOX4	NADPH oxidase 4. (572 aa)
	W5MLT7_LEPOC	Uncharacterized protein. (1240 aa)
	HECTD4	HECT domain-containing protein. (2612 aa)
	LOC102698566	Uncharacterized protein. (421 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (607 aa)
	mcu	Mitochondrial calcium uniporter. (378 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (551 aa)
	LOC102687955	Hexokinase domain containing 1. (914 aa)
	HK1	Hexokinase 1. (985 aa)
	igfbp5	Insulin-like growth factor binding protein 5b. (267 aa)
	W5MSJ7_LEPOC	Uncharacterized protein. (1311 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (283 aa)
	gas6	Uncharacterized protein. (702 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (887 aa)
	W5MVM9_LEPOC	Adiponectin receptor 1a. (387 aa)
	LOC102686811	Uncharacterized protein. (512 aa)
	W5MZ39_LEPOC	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (274 aa)
	ttc33	Non-specific serine/threonine protein kinase. (561 aa)
	sirt1	Sirtuin 1. (720 aa)
	ccdc186	Si:ch211-225b10.4. (911 aa)
	foxk2	Forkhead box K2. (623 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (340 aa)
	W5N3E5_LEPOC	Uncharacterized protein. (1200 aa)
	ASPSCR1	ASPSCR1 tether for SLC2A4, UBX domain containing. (620 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1224 aa)
	W5N9P7_LEPOC	Uncharacterized protein. (379 aa)
	W5NAP7_LEPOC	Uncharacterized protein. (294 aa)
	gck	Phosphotransferase. (478 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	LOC102698058	Hexokinase 2. (923 aa)
	SPX	Spexin hormone. (118 aa)
	slc39a14	Solute carrier family 39 member 14. (485 aa)
	LOC102698487	Leptin a. (172 aa)
	ADGRF5	Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1294 aa)
	adipor2	Adiponectin receptor 2. (356 aa)
	LOC102694194	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
	gckr	Uncharacterized protein. (626 aa)
	W5NJS5_LEPOC	Glutamate-cysteine ligase, catalytic subunit. (632 aa)
	rfx6	Regulatory factor X, 6. (913 aa)
	LOC102687868	Si:dkey-211g8.9. (298 aa)
	LOC102690509	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (293 aa)
	lrrc8d	Leucine rich repeat containing 8 VRAC subunit Da. (830 aa)
	W5NMT7_LEPOC	G protein-coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	LOC102687606	HNF-1_N domain-containing protein. (127 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HECTD4	W5LW90_LEPOC	ENSLOCP00000009363	ENSLOCP00000000397	HECT domain-containing protein.	Uncharacterized protein.	0.951
HECTD4	W5MLT7_LEPOC	ENSLOCP00000009363	ENSLOCP00000009346	HECT domain-containing protein.	Uncharacterized protein.	0.946
HECTD4	W5N9P7_LEPOC	ENSLOCP00000009363	ENSLOCP00000017356	HECT domain-containing protein.	Uncharacterized protein.	0.951
HK1	LOC102687955	ENSLOCP00000011223	ENSLOCP00000011195	Hexokinase 1.	Hexokinase domain containing 1.	0.786
HK1	W5M225_LEPOC	ENSLOCP00000011223	ENSLOCP00000002433	Hexokinase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.875
HK1	W5N3E5_LEPOC	ENSLOCP00000011223	ENSLOCP00000015154	Hexokinase 1.	Uncharacterized protein.	0.803
HK1	gck	ENSLOCP00000011223	ENSLOCP00000018674	Hexokinase 1.	Phosphotransferase.	0.788
HK1	gckr	ENSLOCP00000011223	ENSLOCP00000020702	Hexokinase 1.	Uncharacterized protein.	0.919
HK1	pdx1	ENSLOCP00000011223	ENSLOCP00000005095	Hexokinase 1.	Pancreatic and duodenal homeobox 1.	0.407
HNF1B	LOC102685225	ENSLOCP00000007178	ENSLOCP00000022419	HNF1 homeobox Bb.	Hepatocyte nuclear factor 1-beta-A-like.	0.900
HNF1B	LOC102687606	ENSLOCP00000007178	ENSLOCP00000021960	HNF1 homeobox Bb.	HNF-1_N domain-containing protein.	0.900
LOC102685225	HNF1B	ENSLOCP00000022419	ENSLOCP00000007178	Hepatocyte nuclear factor 1-beta-A-like.	HNF1 homeobox Bb.	0.900
LOC102686811	sirt1	ENSLOCP00000012738	ENSLOCP00000013852	Uncharacterized protein.	Sirtuin 1.	0.437
LOC102687606	HNF1B	ENSLOCP00000021960	ENSLOCP00000007178	HNF-1_N domain-containing protein.	HNF1 homeobox Bb.	0.900
LOC102687955	HK1	ENSLOCP00000011195	ENSLOCP00000011223	Hexokinase domain containing 1.	Hexokinase 1.	0.786
LOC102687955	LOC102698058	ENSLOCP00000011195	ENSLOCP00000018843	Hexokinase domain containing 1.	Hexokinase 2.	0.785
LOC102687955	W5M225_LEPOC	ENSLOCP00000011195	ENSLOCP00000002433	Hexokinase domain containing 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.917
LOC102687955	W5N3E5_LEPOC	ENSLOCP00000011195	ENSLOCP00000015154	Hexokinase domain containing 1.	Uncharacterized protein.	0.867
LOC102687955	gck	ENSLOCP00000011195	ENSLOCP00000018674	Hexokinase domain containing 1.	Phosphotransferase.	0.859
LOC102687955	gckr	ENSLOCP00000011195	ENSLOCP00000020702	Hexokinase domain containing 1.	Uncharacterized protein.	0.919