(105 nodes) Apical junction complex network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLDN8	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (186 aa)
	LOC102698183	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (205 aa)
	pard3	Par-3 family cell polarity regulator alpha, b. (1390 aa)
	W5LXU7_LEPOC	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (252 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	ect2	Epithelial cell transforming 2. (969 aa)
	UBN1	Ubinuclein 1. (1135 aa)
	SAPCD2	Suppressor APC domain containing 2. (432 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (780 aa)
	W5M073_LEPOC	Uncharacterized protein. (277 aa)
	clmp	Uncharacterized protein. (406 aa)
	LOC102688329	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (539 aa)
	mxra8	Matrix-remodelling associated 8b. (426 aa)
	pard6b	Par-6 partitioning defective 6 homolog beta (C. elegans). (381 aa)
	W5M5B9_LEPOC	Pleckstrin homology domain containing, family A member 7b. (1250 aa)
	c1qtnf5	C1q and TNF related 5. (249 aa)
	shroom3	Shroom family member 3. (1904 aa)
	pdzd3	PDZ domain containing 3b. (500 aa)
	marveld2	MARVEL domain containing 2a. (549 aa)
	W5MAE7_LEPOC	Vinculin a. (1122 aa)
	W5MAG4_LEPOC	Uncharacterized protein. (171 aa)
	W5MAJ3_LEPOC	CXADR Ig-like cell adhesion molecule. (375 aa)
	tjp3	Tight junction protein 3; Belongs to the MAGUK family. (1308 aa)
	pdcd6ip	Programmed cell death 6 interacting protein. (884 aa)
	jam3	Junctional adhesion molecule 3a. (302 aa)
	cldn10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (234 aa)
	W5MCB9_LEPOC	Si:busm1-52i16.2. (186 aa)
	LOC102684283	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (262 aa)
	CLDN16	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	W5MCR4_LEPOC	Endothelial cell adhesion molecule a. (398 aa)
	W5MCY7_LEPOC	Lipolysis stimulated lipoprotein receptor. (618 aa)
	cdh5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (770 aa)
	amotl2	Angiomotin like 2b. (728 aa)
	W5MDC6_LEPOC	Crumbs cell polarity complex component 2b. (1450 aa)
	W5MF83_LEPOC	Uncharacterized protein. (127 aa)
	W5MFA5_LEPOC	Nectin cell adhesion molecule 1b. (481 aa)
	cldn18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (251 aa)
	W5MHM2_LEPOC	Uncharacterized protein. (955 aa)
	W5MI66_LEPOC	RAB13, member RAS oncogene family. (162 aa)
	W5MIR0_LEPOC	Par-6 family cell polarity regulator alpha. (369 aa)
	W5MJ54_LEPOC	Uncharacterized protein. (373 aa)
	W5MJ69_LEPOC	Uncharacterized protein. (315 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
	cldn11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	SHROOM2	Shroom family member 2. (1620 aa)
	W5MKN6_LEPOC	Rho/rac guanine nucleotide exchange factor (GEF) 2. (860 aa)
	mpp7	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family. (576 aa)
	crb1	Crumbs cell polarity complex component 1. (1454 aa)
	AMOTL1	Angiomotin like 1. (996 aa)
	W5MLK3_LEPOC	Uncharacterized protein. (487 aa)
	pard6g	Par-6 family cell polarity regulator gamma b. (312 aa)
	cyth3	Cytohesin 1a. (400 aa)
	ccdc85c	Coiled-coil domain containing 85C, b. (405 aa)
	W5MSR5_LEPOC	Nectin cell adhesion molecule 3b. (535 aa)
	W5MT12_LEPOC	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1220 aa)
	W5MTV3_LEPOC	Immunoglobulin-like domain containing receptor 2. (630 aa)
	patj	PATJ crumbs cell polarity complex component. (1899 aa)
	LOC102684856	Si:ch211-191a24.4. (294 aa)
	frmd4b	FERM domain containing 4Bb. (1042 aa)
	magi1	Membrane associated guanylate kinase, WW and PDZ domain containing 1a. (1469 aa)
	W5MXB8_LEPOC	Uncharacterized protein. (1012 aa)
	jam2	Junctional adhesion molecule 2a. (315 aa)
	magi3	Membrane associated guanylate kinase, WW and PDZ domain containing 3b. (1249 aa)
	pard3b	Par-3 family cell polarity regulator beta b. (1206 aa)
	W5N133_LEPOC	SH3-domain binding protein 1. (639 aa)
	frmd6	FERM domain containing 6. (604 aa)
	cyth1	Cytohesin 1b. (397 aa)
	pmp22	Peripheral myelin protein 22b. (157 aa)
	mpdz	Multiple PDZ domain crumbs cell polarity complex component. (2193 aa)
	DDX58	DExD/H-box helicase 58. (940 aa)
	cgnl1	Cingulin-like 1. (1289 aa)
	tjp1	Tight junction protein 1a; Belongs to the MAGUK family. (1966 aa)
	cldn7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (212 aa)
	amot	Angiomotin. (918 aa)
	tbcd	Tubulin folding cofactor D. (1191 aa)
	mpp5	Membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (675 aa)
	SHROOM4	Shroom family member 4. (1570 aa)
	W5NCP4_LEPOC	POF1B actin binding protein. (403 aa)
	nphp1	Nephronophthisis 1. (693 aa)
	W5NGG6_LEPOC	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1307 aa)
	frmd1	FERM domain-containing protein. (597 aa)
	lin7a	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (234 aa)
	bves	Blood vessel epicardial substance. (364 aa)
	tjap1	Tight junction associated protein 1 (peripheral). (674 aa)
	frmd4a	FERM domain containing 4A. (1021 aa)
	CLDN14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
	W5NLM3_LEPOC	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (214 aa)
	LOC102699254	Claudin 3. (216 aa)
	LOC102682341	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	LOC102682539	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	LOC102682740	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	LOC102682945	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	LOC102696734	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (242 aa)
	LOC102683350	Zgc:136892. (210 aa)
	LOC102683559	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	cldn2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (275 aa)
	W5NLZ6_LEPOC	Claudin 23a. (269 aa)
	LOC102687167	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
	W5NMN6_LEPOC	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	CLDN34	Claudin 34. (215 aa)
	CLDN8-2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (226 aa)
	W5NNN1_LEPOC	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	LOC102687015	Si:dkey-221l4.11. (138 aa)
	cldn12	Claudin 12. (327 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOTL1	W5N133_LEPOC	ENSLOCP00000009170	ENSLOCP00000014342	Angiomotin like 1.	SH3-domain binding protein 1.	0.670
AMOTL1	amot	ENSLOCP00000009170	ENSLOCP00000017095	Angiomotin like 1.	Angiomotin.	0.701
AMOTL1	amotl2	ENSLOCP00000009170	ENSLOCP00000006336	Angiomotin like 1.	Angiomotin like 2b.	0.831
AMOTL1	mpdz	ENSLOCP00000009170	ENSLOCP00000016324	Angiomotin like 1.	Multiple PDZ domain crumbs cell polarity complex component.	0.869
AMOTL1	mpp5	ENSLOCP00000009170	ENSLOCP00000017435	Angiomotin like 1.	Membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.940
AMOTL1	mpp7	ENSLOCP00000009170	ENSLOCP00000009014	Angiomotin like 1.	Membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7); Belongs to the MAGUK family.	0.711
AMOTL1	patj	ENSLOCP00000009170	ENSLOCP00000012164	Angiomotin like 1.	PATJ crumbs cell polarity complex component.	0.869
AMOTL1	prkci	ENSLOCP00000009170	ENSLOCP00000008763	Angiomotin like 1.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.868
CLDN1	CLDN14	ENSLOCP00000006154	ENSLOCP00000021521	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.868
CLDN1	CLDN16	ENSLOCP00000006154	ENSLOCP00000006133	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.847
CLDN1	CLDN34	ENSLOCP00000006154	ENSLOCP00000021896	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 34.	0.862
CLDN1	CLDN8	ENSLOCP00000006154	ENSLOCP00000011118	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.797
CLDN1	CLDN8-2	ENSLOCP00000006154	ENSLOCP00000022152	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.798
CLDN1	LOC102682341	ENSLOCP00000006154	ENSLOCP00000021534	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.870
CLDN1	LOC102682539	ENSLOCP00000006154	ENSLOCP00000021535	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.717
CLDN1	LOC102682740	ENSLOCP00000006154	ENSLOCP00000021536	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.717
CLDN1	LOC102682945	ENSLOCP00000006154	ENSLOCP00000021537	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.717
CLDN1	LOC102683350	ENSLOCP00000006154	ENSLOCP00000021539	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Zgc:136892.	0.718
CLDN1	LOC102683559	ENSLOCP00000006154	ENSLOCP00000021540	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.879
CLDN1	LOC102687167	ENSLOCP00000006154	ENSLOCP00000021871	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.888