(62 nodes) Dicarboxylic acid metabolic process network (Lepisosteus oculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	mdh2	Malate dehydrogenase. (337 aa)
	idh2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
	tat	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
	acot8	Acyl-CoA thioesterase 8. (343 aa)
	me2	Malic enzyme. (583 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (935 aa)
	W5N5L7_LEPOC	Glutaminase like. (646 aa)
	W5N639_LEPOC	N-acetylglutamate synthase. (518 aa)
	dglucy	D-glutamate cyclase. (626 aa)
	mtrr	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (728 aa)
	LOC102687756	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	LOC102692206	D-glutamate cyclase. (624 aa)
	me1	Malic enzyme. (588 aa)
	LOC102683765	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (631 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (464 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (579 aa)
	aldh4a1	IF rod domain-containing protein; Belongs to the aldehyde dehydrogenase family. (1495 aa)
	adhfe1	Alcohol dehydrogenase iron containing 1. (471 aa)
	W5NJS5_LEPOC	Glutamate-cysteine ligase, catalytic subunit. (632 aa)
	fh	Fumarate hydratase. (506 aa)
	kmo	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (476 aa)
	haao	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (289 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
	mdh1	Malate dehydrogenase. (350 aa)
	LOC102685943	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (635 aa)
	amdhd1	Amidohydrolase domain containing 1. (445 aa)
	hal	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (654 aa)
	W5MBX6_LEPOC	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (489 aa)
	gls2	Glutaminase 2b (liver, mitochondrial). (609 aa)
	OGDH	Oxoglutarate dehydrogenase. (1003 aa)
	W5ND16_LEPOC	Aldehyde dehydrogenase 1 family, member L2; Belongs to the aldehyde dehydrogenase family. (604 aa)
	LOC102689506	Glutamic-oxaloacetic transaminase 1 like 1. (413 aa)
	LOC102683593	Zgc:113208. (162 aa)
	aadat	Aminoadipate aminotransferase. (424 aa)
	W5N4K7_LEPOC	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1126 aa)
	QPRT	Quinolinate phosphoribosyltransferase. (283 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (782 aa)
	sdhaf3	Succinate dehydrogenase complex assembly factor 3. (125 aa)
	dlst	Dihydrolipoamide S-succinyltransferase. (460 aa)
	nit2	Nitrilase family, member 2. (285 aa)
	mdh1b	Malate dehydrogenase 1B, NAD (soluble). (468 aa)
	LOC102684922	2-epi-5-epi-valiolone synthase. (451 aa)
	gls	Glutaminase a. (636 aa)
	gclm	Glutamate-cysteine ligase, modifier subunit. (283 aa)
	me3	Malic enzyme. (619 aa)
	got1	Aspartate aminotransferase. (413 aa)
	LOC102697165	Si:ch211-217a12.1. (489 aa)
	ftcd	Formimidoyltransferase cyclodeaminase. (546 aa)
	LOC102699097	Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (355 aa)
	LOC102689111	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (353 aa)
	oat	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa)
	gad2	Glutamate decarboxylase 2. (581 aa)
	mrps36	Mitochondrial ribosomal protein S36. (168 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (623 aa)
	d2hgdh	D-2-hydroxyglutarate dehydrogenase. (533 aa)
	got2	Aspartate aminotransferase. (446 aa)
	W5MG14_LEPOC	Serine hydroxymethyltransferase 2 (mitochondrial). (504 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa)
	W5MDF7_LEPOC	Folylpolyglutamate synthase. (586 aa)
	LOC102694103	Zgc:153901. (326 aa)
	LOC102694674	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
	kynu	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (467 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSF3	LOC102685943	ENSLOCP00000005571	ENSLOCP00000019405	Acyl-CoA synthetase family member 3.	Histidine ammonia-lyase; Belongs to the PAL/histidase family.	0.508
ACSF3	LOC102687756	ENSLOCP00000005571	ENSLOCP00000016926	Acyl-CoA synthetase family member 3.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.563
ACSF3	LOC102689506	ENSLOCP00000005571	ENSLOCP00000018416	Acyl-CoA synthetase family member 3.	Glutamic-oxaloacetic transaminase 1 like 1.	0.619
ACSF3	W5N4K7_LEPOC	ENSLOCP00000005571	ENSLOCP00000015566	Acyl-CoA synthetase family member 3.	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	0.450
ACSF3	W5ND16_LEPOC	ENSLOCP00000005571	ENSLOCP00000018525	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase 1 family, member L2; Belongs to the aldehyde dehydrogenase family.	0.563
ACSF3	aadat	ENSLOCP00000005571	ENSLOCP00000015705	Acyl-CoA synthetase family member 3.	Aminoadipate aminotransferase.	0.475
ACSF3	aldh4a1	ENSLOCP00000005571	ENSLOCP00000005581	Acyl-CoA synthetase family member 3.	IF rod domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.621
ACSF3	aldh5a1	ENSLOCP00000005571	ENSLOCP00000007105	Acyl-CoA synthetase family member 3.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.563
ACSF3	dlst	ENSLOCP00000005571	ENSLOCP00000013103	Acyl-CoA synthetase family member 3.	Dihydrolipoamide S-succinyltransferase.	0.412
ACSF3	got1	ENSLOCP00000005571	ENSLOCP00000011040	Acyl-CoA synthetase family member 3.	Aspartate aminotransferase.	0.619
ACSF3	got2	ENSLOCP00000005571	ENSLOCP00000007825	Acyl-CoA synthetase family member 3.	Aspartate aminotransferase.	0.710
ACSF3	hal	ENSLOCP00000005571	ENSLOCP00000019370	Acyl-CoA synthetase family member 3.	Histidine ammonia-lyase; Belongs to the PAL/histidase family.	0.508
ACSF3	kmo	ENSLOCP00000005571	ENSLOCP00000020480	Acyl-CoA synthetase family member 3.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.505
ACSF3	nit2	ENSLOCP00000005571	ENSLOCP00000013061	Acyl-CoA synthetase family member 3.	Nitrilase family, member 2.	0.453
ACSF3	tat	ENSLOCP00000005571	ENSLOCP00000003268	Acyl-CoA synthetase family member 3.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.534
ALDH18A1	LOC102683593	ENSLOCP00000014981	ENSLOCP00000018151	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Zgc:113208.	0.580
ALDH18A1	LOC102683765	ENSLOCP00000014981	ENSLOCP00000004446	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.955
ALDH18A1	LOC102684922	ENSLOCP00000014981	ENSLOCP00000012291	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	2-epi-5-epi-valiolone synthase.	0.781
ALDH18A1	LOC102685943	ENSLOCP00000014981	ENSLOCP00000019405	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Histidine ammonia-lyase; Belongs to the PAL/histidase family.	0.408
ALDH18A1	LOC102687756	ENSLOCP00000014981	ENSLOCP00000016926	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.946