(78 nodes) Positive regulation of translation network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102683838	RRM domain-containing protein. (213 aa)
	LOC102684042	RRM domain-containing protein. (121 aa)
	elavl1	ELAV-like protein; Belongs to the RRM elav family. (340 aa)
	LOC102684502	RCC1 like. (403 aa)
	W5LWZ5_LEPOC	Fragile X mental retardation, autosomal homolog 1. (683 aa)
	trub2	TruB pseudouridine (psi) synthase family member 2. (303 aa)
	CDK5RAP1	CDK5 regulatory subunit associated protein 1. (583 aa)
	W5M1H6_LEPOC	RCC1 like. (329 aa)
	pink1	PTEN induced kinase 1. (581 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1019 aa)
	W5M2C1_LEPOC	DEAH (Asp-Glu-Ala-His) box helicase 9. (1268 aa)
	upf3a	UPF3A regulator of nonsense mediated mRNA decay. (462 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	nckap5	NCK associated protein 5. (2025 aa)
	nat10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1002 aa)
	lin28a	Lin-28 homolog A (C. elegans). (203 aa)
	eif2s3	Eukaryotic translation initiation factor 2, subunit 3 gamma. (472 aa)
	W5M765_LEPOC	Eukaryotic translation initiation factor 4 gamma, 3b. (1716 aa)
	rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (508 aa)
	BOLL	Boule homolog, RNA binding protein. (279 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (725 aa)
	W5MC23_LEPOC	YTH N(6)-methyladenosine RNA binding protein 3. (586 aa)
	ythdf1	YTH N(6)-methyladenosine RNA binding protein 1. (580 aa)
	W5MCE8_LEPOC	RRM domain-containing protein. (147 aa)
	dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3a. (504 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
	impact	Impact RWD domain protein. (327 aa)
	dazl	Deleted in azoospermia-like. (240 aa)
	pcif1	PDX1 C-terminal inhibiting factor 1. (741 aa)
	W5MJN0_LEPOC	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (492 aa)
	larp4	La ribonucleoprotein domain family, member 4Ab. (784 aa)
	uhmk1	U2AF homology motif (UHM) kinase 1. (431 aa)
	eif5a2	Eukaryotic translation initiation factor 5A. (159 aa)
	tent4b	Terminal nucleotidyltransferase 4B. (670 aa)
	nck1	Cytoplasmic protein. (380 aa)
	mettl5	Methyltransferase like 5. (211 aa)
	W5MMW6_LEPOC	Ribosomal protein S9. (200 aa)
	LOC102696238	HTH La-type RNA-binding domain-containing protein. (503 aa)
	tent4a	Terminal nucleotidyltransferase 4A. (768 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1709 aa)
	nck2	Cytoplasmic protein. (381 aa)
	prr16	Proline rich 16. (316 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase. (824 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	habp4	Hyaluronan binding protein 4. (416 aa)
	jmjd4	Jumonji domain containing 4. (429 aa)
	dhx29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1377 aa)
	fastkd2	RAP domain-containing protein. (690 aa)
	W5MXI4_LEPOC	La ribonucleoprotein domain family, member 1B. (1003 aa)
	mrps27	Mitochondrial ribosomal protein S27. (414 aa)
	fastkd3	FAST kinase domains 3. (665 aa)
	ctif	CBP80/20-dependent translation initiation factor. (672 aa)
	W5N236_LEPOC	Polymerase (DNA-directed), delta interacting protein 3. (332 aa)
	paip1	Poly(A) binding protein interacting protein 1. (477 aa)
	larp4b	La ribonucleoprotein domain family, member 4B. (774 aa)
	ngrn	Neugrin, neurite outgrowth associated. (314 aa)
	W5N3N0_LEPOC	Cytochrome C oxidase assembly factor 3a. (102 aa)
	GUF1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (667 aa)
	W5N3X8_LEPOC	La ribonucleoprotein domain family, member 1. (999 aa)
	LOC102691989	Ubiquinol-cytochrome c reductase complex assembly factor 2. (125 aa)
	W5N4K6_LEPOC	Uncharacterized protein. (623 aa)
	W5N4L0_LEPOC	Uncharacterized protein. (303 aa)
	zcchc4	Zinc finger, CCHC domain containing 4. (507 aa)
	W5N6Q1_LEPOC	Fragile X mental retardation, autosomal homolog 2. (651 aa)
	mif4gd	MIF4G domain containing a. (235 aa)
	EIF5AL1	Eukaryotic translation initiation factor 5A. (157 aa)
	LOC102683785	DnaJ (Hsp40) homolog, subfamily C, member 3b. (501 aa)
	cnbp	CCHC-type zinc finger, nucleic acid binding protein b. (175 aa)
	larp6	La ribonucleoprotein domain family, member 6a. (654 aa)
	foxa3	Forkhead box A3. (439 aa)
	upf3b	UPF3B regulator of nonsense mediated mRNA decay. (452 aa)
	fmr1	Fragile X mental retardation 1. (614 aa)
	rmnd1	Required for meiotic nuclear division 1 homolog. (328 aa)
	LOC102695612	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (534 aa)
	W5NMF6_LEPOC	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	trmt10c	tRNA methyltransferase 10C, mitochondrial RNase P subunit. (445 aa)
	W5NN84_LEPOC	Urotensin 1. (161 aa)
	W5LVC6_LEPOC	Uncharacterized protein. (138 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOLL	EIF4G1	ENSLOCP00000004776	ENSLOCP00000010629	Boule homolog, RNA binding protein.	Eukaryotic translation initiation factor 4 gamma 1.	0.507
BOLL	W5M765_LEPOC	ENSLOCP00000004776	ENSLOCP00000004223	Boule homolog, RNA binding protein.	Eukaryotic translation initiation factor 4 gamma, 3b.	0.507
BOLL	W5N236_LEPOC	ENSLOCP00000004776	ENSLOCP00000014695	Boule homolog, RNA binding protein.	Polymerase (DNA-directed), delta interacting protein 3.	0.481
BOLL	eif2s3	ENSLOCP00000004776	ENSLOCP00000003988	Boule homolog, RNA binding protein.	Eukaryotic translation initiation factor 2, subunit 3 gamma.	0.567
BOLL	lin28a	ENSLOCP00000004776	ENSLOCP00000003958	Boule homolog, RNA binding protein.	Lin-28 homolog A (C. elegans).	0.498
BOLL	paip1	ENSLOCP00000004776	ENSLOCP00000015098	Boule homolog, RNA binding protein.	Poly(A) binding protein interacting protein 1.	0.507
BOLL	polr2d	ENSLOCP00000004776	ENSLOCP00000011102	Boule homolog, RNA binding protein.	Polymerase (RNA) II (DNA directed) polypeptide D.	0.532
EIF4G1	BOLL	ENSLOCP00000010629	ENSLOCP00000004776	Eukaryotic translation initiation factor 4 gamma 1.	Boule homolog, RNA binding protein.	0.507
EIF4G1	LOC102683838	ENSLOCP00000010629	ENSLOCP00000000115	Eukaryotic translation initiation factor 4 gamma 1.	RRM domain-containing protein.	0.507
EIF4G1	LOC102684042	ENSLOCP00000010629	ENSLOCP00000000126	Eukaryotic translation initiation factor 4 gamma 1.	RRM domain-containing protein.	0.507
EIF4G1	W5LVC6_LEPOC	ENSLOCP00000010629	ENSLOCP00000000083	Eukaryotic translation initiation factor 4 gamma 1.	Uncharacterized protein.	0.654
EIF4G1	W5M765_LEPOC	ENSLOCP00000010629	ENSLOCP00000004223	Eukaryotic translation initiation factor 4 gamma 1.	Eukaryotic translation initiation factor 4 gamma, 3b.	0.788
EIF4G1	W5MCE8_LEPOC	ENSLOCP00000010629	ENSLOCP00000006057	Eukaryotic translation initiation factor 4 gamma 1.	RRM domain-containing protein.	0.507
EIF4G1	W5MJN0_LEPOC	ENSLOCP00000010629	ENSLOCP00000008589	Eukaryotic translation initiation factor 4 gamma 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.675
EIF4G1	W5MMW6_LEPOC	ENSLOCP00000010629	ENSLOCP00000009725	Eukaryotic translation initiation factor 4 gamma 1.	Ribosomal protein S9.	0.612
EIF4G1	W5MXI4_LEPOC	ENSLOCP00000010629	ENSLOCP00000013093	Eukaryotic translation initiation factor 4 gamma 1.	La ribonucleoprotein domain family, member 1B.	0.533
EIF4G1	W5N3X8_LEPOC	ENSLOCP00000010629	ENSLOCP00000015337	Eukaryotic translation initiation factor 4 gamma 1.	La ribonucleoprotein domain family, member 1.	0.533
EIF4G1	dazl	ENSLOCP00000010629	ENSLOCP00000007796	Eukaryotic translation initiation factor 4 gamma 1.	Deleted in azoospermia-like.	0.507
EIF4G1	eif2s3	ENSLOCP00000010629	ENSLOCP00000003988	Eukaryotic translation initiation factor 4 gamma 1.	Eukaryotic translation initiation factor 2, subunit 3 gamma.	0.707
EIF4G1	nat10	ENSLOCP00000010629	ENSLOCP00000003423	Eukaryotic translation initiation factor 4 gamma 1.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.483