(33 nodes) Pigment biosynthetic process network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	isca1	Iron-sulfur cluster assembly 1. (129 aa)
	rpe65	Retinoid isomerohydrolase RPE65 b. (533 aa)
	fxn	Frataxin. (122 aa)
	iba57	Iron-sulfur cluster assembly factor IBA57. (351 aa)
	oca2	Oculocutaneous albinism II. (834 aa)
	W5MA17_LEPOC	Uncharacterized protein. (93 aa)
	W5MBE3_LEPOC	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (457 aa)
	trpc1	Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
	uros	Uroporphyrinogen III synthase. (261 aa)
	phyhipl	Phytanoyl-CoA 2-hydroxylase interacting protein-like a. (376 aa)
	dct	Dopachrome tautomerase. (520 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (106 aa)
	LOC102688695	Fibronectin type-III domain-containing protein. (336 aa)
	W5NB93_LEPOC	5-aminolevulinate synthase. (641 aa)
	pgrmc1	Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (187 aa)
	alas1	5-aminolevulinate synthase. (642 aa)
	slc25a39	Solute carrier family 25 member 39; Belongs to the mitochondrial carrier (TC 2.A.29) family. (357 aa)
	tyrp1	Tyrosinase-related protein 1a. (536 aa)
	tmem14c	Transmembrane protein 14Ca. (88 aa)
	LOC102695473	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. (461 aa)
	LOC102685731	Cytochrome c oxidase assembly homolog 15 (yeast). (405 aa)
	W5MVH8_LEPOC	Coproporphyrinogen oxidase. (436 aa)
	W5MVF6_LEPOC	Uncharacterized protein. (314 aa)
	LOC102694116	Uncharacterized protein. (302 aa)
	LOC102685240	5-aminolevulinate synthase. (485 aa)
	tyr	Tyrosinase. (540 aa)
	LOC102695813	D-dopachrome tautomerase. (118 aa)
	hmbs	Hydroxymethylbilane synthase a. (362 aa)
	W5M7C8_LEPOC	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (415 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (373 aa)
	urod	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (375 aa)
	alad	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (359 aa)
	W5LZ20_LEPOC	Melanocyte-stimulating hormone receptor. (330 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102685240	W5M7C8_LEPOC	ENSLOCP00000009502	ENSLOCP00000004286	5-aminolevulinate synthase.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.430
LOC102685240	W5NB93_LEPOC	ENSLOCP00000009502	ENSLOCP00000017902	5-aminolevulinate synthase.	5-aminolevulinate synthase.	0.787
LOC102685240	alad	ENSLOCP00000009502	ENSLOCP00000000732	5-aminolevulinate synthase.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.872
LOC102685240	hmbs	ENSLOCP00000009502	ENSLOCP00000004461	5-aminolevulinate synthase.	Hydroxymethylbilane synthase a.	0.405
LOC102685731	LOC102694116	ENSLOCP00000015706	ENSLOCP00000012352	Cytochrome c oxidase assembly homolog 15 (yeast).	Uncharacterized protein.	0.459
LOC102685731	LOC102695473	ENSLOCP00000015706	ENSLOCP00000016197	Cytochrome c oxidase assembly homolog 15 (yeast).	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.	0.997
LOC102685731	W5M7C8_LEPOC	ENSLOCP00000015706	ENSLOCP00000004286	Cytochrome c oxidase assembly homolog 15 (yeast).	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.947
LOC102685731	W5MBE3_LEPOC	ENSLOCP00000015706	ENSLOCP00000005702	Cytochrome c oxidase assembly homolog 15 (yeast).	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	0.650
LOC102685731	W5MVF6_LEPOC	ENSLOCP00000015706	ENSLOCP00000012365	Cytochrome c oxidase assembly homolog 15 (yeast).	Uncharacterized protein.	0.459
LOC102685731	W5MVH8_LEPOC	ENSLOCP00000015706	ENSLOCP00000012387	Cytochrome c oxidase assembly homolog 15 (yeast).	Coproporphyrinogen oxidase.	0.459
LOC102685731	alad	ENSLOCP00000015706	ENSLOCP00000000732	Cytochrome c oxidase assembly homolog 15 (yeast).	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.564
LOC102685731	hmbs	ENSLOCP00000015706	ENSLOCP00000004461	Cytochrome c oxidase assembly homolog 15 (yeast).	Hydroxymethylbilane synthase a.	0.589
LOC102685731	urod	ENSLOCP00000015706	ENSLOCP00000003510	Cytochrome c oxidase assembly homolog 15 (yeast).	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.	0.460
LOC102685731	uros	ENSLOCP00000015706	ENSLOCP00000009576	Cytochrome c oxidase assembly homolog 15 (yeast).	Uroporphyrinogen III synthase.	0.581
LOC102694116	LOC102685731	ENSLOCP00000012352	ENSLOCP00000015706	Uncharacterized protein.	Cytochrome c oxidase assembly homolog 15 (yeast).	0.459
LOC102694116	W5M7C8_LEPOC	ENSLOCP00000012352	ENSLOCP00000004286	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.478
LOC102694116	W5MBE3_LEPOC	ENSLOCP00000012352	ENSLOCP00000005702	Uncharacterized protein.	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	0.884
LOC102694116	W5MVH8_LEPOC	ENSLOCP00000012352	ENSLOCP00000012387	Uncharacterized protein.	Coproporphyrinogen oxidase.	0.569
LOC102694116	alad	ENSLOCP00000012352	ENSLOCP00000000732	Uncharacterized protein.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.518
LOC102694116	hmbs	ENSLOCP00000012352	ENSLOCP00000004461	Uncharacterized protein.	Hydroxymethylbilane synthase a.	0.548