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LOC102685258 LOC102685258 FGF1 FGF1 W5MTJ8_LEPOC W5MTJ8_LEPOC hhip hhip ednra ednra sfrp2 sfrp2 edn1 edn1 W5MM76_LEPOC W5MM76_LEPOC ctnnbip1 ctnnbip1 W5MIF3_LEPOC W5MIF3_LEPOC ctsz ctsz W5MEK4_LEPOC W5MEK4_LEPOC gbx2 gbx2 dlg5 dlg5 wt1 wt1 timeless timeless PKD1 PKD1 LOC102692092 LOC102692092 lrp5 lrp5 tgfbr2 tgfbr2 W5LYF8_LEPOC W5LYF8_LEPOC W5LWI8_LEPOC W5LWI8_LEPOC LOC102694913 LOC102694913 spry1 spry1 nrarp nrarp gdf7 gdf7 W5NIY6_LEPOC W5NIY6_LEPOC lrp6 lrp6 tcf21 tcf21 ppp3r1 ppp3r1 srf srf W5NDW5_LEPOC W5NDW5_LEPOC nkx3-1 nkx3-1 pml pml ar ar ctsh ctsh W5N9Y4_LEPOC W5N9Y4_LEPOC plekhh1 plekhh1 W5N7T1_LEPOC W5N7T1_LEPOC dag1 dag1 W5N5D9_LEPOC W5N5D9_LEPOC med1 med1 gdnf gdnf W5N4A3_LEPOC W5N4A3_LEPOC lef1 lef1 W5N2I6_LEPOC W5N2I6_LEPOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102685258Polycystic kidney disease 1b. (4540 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
W5MTJ8_LEPOCIntegrin-linked kinase. (454 aa)
hhipHedgehog interacting protein. (703 aa)
ednraEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (433 aa)
sfrp2Secreted frizzled-related protein 2. (298 aa)
edn1Endothelin 1. (200 aa)
W5MM76_LEPOCUncharacterized protein. (307 aa)
ctnnbip1Catenin, beta interacting protein 1. (81 aa)
W5MIF3_LEPOCMothers against decapentaplegic homolog. (556 aa)
ctszCathepsin Z; Belongs to the peptidase C1 family. (312 aa)
W5MEK4_LEPOCUncharacterized protein. (96 aa)
gbx2Gastrulation brain homeobox 2. (342 aa)
dlg5Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (2023 aa)
wt1WT1 transcription factor a. (418 aa)
timelessTimeless circadian clock. (1225 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4422 aa)
LOC102692092TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1602 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
W5LYF8_LEPOCMKS transition zone complex subunit 1. (565 aa)
W5LWI8_LEPOCTransmembrane protein 59-like. (208 aa)
LOC102694913Uncharacterized protein. (319 aa)
spry1Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (321 aa)
nrarpNOTCH regulated ankyrin repeat protein a. (112 aa)
gdf7Growth differentiation factor 7. (417 aa)
W5NIY6_LEPOCGrowth regulating estrogen receptor binding 1. (1937 aa)
lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
tcf21Transcription factor 21. (179 aa)
ppp3r1Protein phosphatase 3, regulatory subunit B, alpha a. (169 aa)
srfSerum response factor b. (605 aa)
W5NDW5_LEPOCPeptidase S72 domain-containing protein. (629 aa)
nkx3-1NK3 homeobox 1. (220 aa)
pmlUncharacterized protein. (766 aa)
arAndrogen receptor. (859 aa)
ctshCathepsin H; Belongs to the peptidase C1 family. (331 aa)
W5N9Y4_LEPOCTransforming growth factor beta; Belongs to the TGF-beta family. (392 aa)
plekhh1Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1. (1480 aa)
W5N7T1_LEPOCUncharacterized protein. (532 aa)
dag1Dystroglycan 1. (874 aa)
W5N5D9_LEPOCMothers against decapentaplegic homolog. (547 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1734 aa)
gdnfGlial cell derived neurotrophic factor a. (223 aa)
W5N4A3_LEPOCSeryl-tRNA synthetase. (518 aa)
lef1Lymphoid enhancer-binding factor 1. (397 aa)
W5N2I6_LEPOCColony stimulating factor 1b (macrophage). (250 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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