(63 nodes) Catalytic step 2 spliceosome network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRRM1	Serine and arginine repetitive matrix 1. (902 aa)
	sf3a3	Splicing factor 3a, subunit 3. (501 aa)
	sf3b1	Splicing factor 3b, subunit 1. (1317 aa)
	dhx38	DEAH (Asp-Glu-Ala-His) box polypeptide 38. (1252 aa)
	lsm7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
	hnrnpr	Heterogeneous nuclear ribonucleoprotein R. (635 aa)
	hnrnpm	Heterogeneous nuclear ribonucleoprotein M. (654 aa)
	dhx35	DEAH-box helicase 35. (699 aa)
	prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (995 aa)
	ess2	Ess-2 splicing factor homolog. (481 aa)
	lsm2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	snrnp40	Small nuclear ribonucleoprotein 40 (U5). (350 aa)
	prpf8	Pre-mRNA processing factor 8. (2338 aa)
	zcchc8	Zinc finger, CCHC domain containing 8. (712 aa)
	sf3a2	Splicing factor 3a, subunit 2. (310 aa)
	wdr83	WD repeat domain containing 83. (315 aa)
	cwc22	CWC22 spliceosome associated protein homolog. (1041 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	W5MJA1_LEPOC	XPA binding protein 2. (845 aa)
	ddx23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23. (818 aa)
	cwc15	CWC15 spliceosome associated protein homolog. (234 aa)
	W5MNA9_LEPOC	Pre-mRNA processing factor 19. (465 aa)
	sf3a1	Splicing factor 3a, subunit 1. (791 aa)
	plrg1	Pleiotropic regulator 1. (520 aa)
	W5MQR5_LEPOC	SNW domain containing 1. (535 aa)
	pnn	Pinin, desmosome associated protein. (645 aa)
	mtrex	Mtr4 exosome RNA helicase. (1032 aa)
	bcas2	BCAS2 pre-mRNA processing factor. (229 aa)
	ppwd1	Peptidylprolyl isomerase domain and WD repeat containing 1. (626 aa)
	cwc27	CWC27 spliceosome associated cyclophilin. (479 aa)
	rbm22	RNA binding motif protein 22. (426 aa)
	eftud2	Elongation factor Tu GTP binding domain containing 2. (977 aa)
	WDR25	WD repeat domain 25. (449 aa)
	snrpe	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (92 aa)
	DDX41	DEAD-box helicase 41. (616 aa)
	prpf4b	Pre-mRNA processing factor 4Ba. (1037 aa)
	dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8. (1203 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1463 aa)
	ppil1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	lsm3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	isy1	ISY1 splicing factor homolog. (319 aa)
	snrpa1	Small nuclear ribonucleoprotein polypeptide A. (261 aa)
	W5NBN6_LEPOC	Zgc:153119. (253 aa)
	snrpd2	Small nuclear ribonucleoprotein Sm D2. (118 aa)
	W5NCM6_LEPOC	DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1182 aa)
	W5NDC8_LEPOC	RNA binding motif protein X-linked. (401 aa)
	snrnp200	Small nuclear ribonucleoprotein 200 (U5). (2138 aa)
	snrpg	Small nuclear ribonucleoprotein G. (76 aa)
	snrpf	Small nuclear ribonucleoprotein polypeptide F. (86 aa)
	sf3b6	Splicing factor 3b, subunit 6. (125 aa)
	crnkl1	Crooked neck pre-mRNA splicing factor 1. (725 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (577 aa)
	W5M189_LEPOC	Uncharacterized protein. (170 aa)
	gpatch1	G patch domain containing 1. (941 aa)
	LOC107076457	Uncharacterized protein. (171 aa)
	LOC107076440	PSP domain-containing protein. (75 aa)
	W5LVC1_LEPOC	Uncharacterized protein. (168 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (500 aa)
	snrpd1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (117 aa)
	W5M1R2_LEPOC	Peptidylprolyl isomerase (cyclophilin)-like 2. (595 aa)
	LOC102686698	Small nuclear ribonucleoprotein-associated protein. (238 aa)
	syf2	SYF2 pre-mRNA-splicing factor. (251 aa)
	W5M5R0_LEPOC	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (168 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX41	SRRM1	ENSLOCP00000014704	ENSLOCP00000003273	DEAD-box helicase 41.	Serine and arginine repetitive matrix 1.	0.737
DDX41	W5M1R2_LEPOC	ENSLOCP00000014704	ENSLOCP00000002320	DEAD-box helicase 41.	Peptidylprolyl isomerase (cyclophilin)-like 2.	0.592
DDX41	W5M5R0_LEPOC	ENSLOCP00000014704	ENSLOCP00000003718	DEAD-box helicase 41.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.682
DDX41	W5NCM6_LEPOC	ENSLOCP00000014704	ENSLOCP00000018385	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 34.	0.725
DDX41	WDR25	ENSLOCP00000014704	ENSLOCP00000014246	DEAD-box helicase 41.	WD repeat domain 25.	0.691
DDX41	cdc40	ENSLOCP00000014704	ENSLOCP00000021196	DEAD-box helicase 41.	Cell division cycle 40 homolog (S. cerevisiae).	0.737
DDX41	cwc22	ENSLOCP00000014704	ENSLOCP00000007800	DEAD-box helicase 41.	CWC22 spliceosome associated protein homolog.	0.727
DDX41	cwc27	ENSLOCP00000014704	ENSLOCP00000013017	DEAD-box helicase 41.	CWC27 spliceosome associated cyclophilin.	0.442
DDX41	ddx23	ENSLOCP00000014704	ENSLOCP00000008960	DEAD-box helicase 41.	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23.	0.592
DDX41	dhx35	ENSLOCP00000014704	ENSLOCP00000005562	DEAD-box helicase 41.	DEAH-box helicase 35.	0.723
DDX41	dhx38	ENSLOCP00000014704	ENSLOCP00000004993	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 38.	0.761
DDX41	dhx8	ENSLOCP00000014704	ENSLOCP00000014950	DEAD-box helicase 41.	DEAH (Asp-Glu-Ala-His) box polypeptide 8.	0.725
DDX41	gpatch1	ENSLOCP00000014704	ENSLOCP00000002121	DEAD-box helicase 41.	G patch domain containing 1.	0.675
DDX41	mtrex	ENSLOCP00000014704	ENSLOCP00000012471	DEAD-box helicase 41.	Mtr4 exosome RNA helicase.	0.694
DDX41	ppil1	ENSLOCP00000014704	ENSLOCP00000015508	DEAD-box helicase 41.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.711
DDX41	ppwd1	ENSLOCP00000014704	ENSLOCP00000012984	DEAD-box helicase 41.	Peptidylprolyl isomerase domain and WD repeat containing 1.	0.867
LOC102686698	LOC107076440	ENSLOCP00000003155	ENSLOCP00000000090	Small nuclear ribonucleoprotein-associated protein.	PSP domain-containing protein.	0.989
LOC102686698	LOC107076457	ENSLOCP00000003155	ENSLOCP00000000190	Small nuclear ribonucleoprotein-associated protein.	Uncharacterized protein.	0.799
LOC102686698	SART1	ENSLOCP00000003155	ENSLOCP00000002163	Small nuclear ribonucleoprotein-associated protein.	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP.	0.924
LOC102686698	SRRM1	ENSLOCP00000003155	ENSLOCP00000003273	Small nuclear ribonucleoprotein-associated protein.	Serine and arginine repetitive matrix 1.	0.861