63 items (Lepisosteus oculatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	W5MKE7_LEPOC	Prostaglandin E synthase 3b (cytosolic). (146 aa)
	W5LXC3_LEPOC	Uncharacterized protein. (466 aa)
	W5LXJ3_LEPOC	DNA_pol_B domain-containing protein. (97 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (375 aa)
	W5LZH0_LEPOC	HTH myb-type domain-containing protein. (575 aa)
	W5LZL8_LEPOC	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1199 aa)
	W5M103_LEPOC	DNA ligase. (1030 aa)
	pola1	DNA polymerase. (1486 aa)
	lig3	DNA ligase. (1001 aa)
	W5M2K0_LEPOC	Polymerase (DNA directed) nu. (728 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa)
	W5M4C0_LEPOC	Reverse transcriptase domain-containing protein. (510 aa)
	W5M4D3_LEPOC	Uncharacterized protein. (495 aa)
	W5M613_LEPOC	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (842 aa)
	poli	Polymerase (DNA directed) iota. (737 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (638 aa)
	W5M709_LEPOC	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1056 aa)
	spata22	Spermatogenesis associated 22. (441 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
	tk2	Thymidine kinase 2. (164 aa)
	W5MDZ8_LEPOC	Polymerase (DNA directed) kappa. (839 aa)
	W5MET7_LEPOC	Polymerase (DNA directed), theta. (2592 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC107080026	Uncharacterized protein. (628 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (494 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (174 aa)
	parp10	Poly [ADP-ribose] polymerase. (1024 aa)
	W5MR27_LEPOC	DNA ligase. (924 aa)
	nhp2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
	LOC102686545	Zgc:136908; Belongs to the AAA ATPase family. (807 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	W5MXE6_LEPOC	Uncharacterized protein. (199 aa)
	W5MXW8_LEPOC	WRN RecQ like helicase. (1464 aa)
	sirt1	Sirtuin 1. (720 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	phb	Prohibitin. (273 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (579 aa)
	GAR1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (234 aa)
	W5N206_LEPOC	Uncharacterized protein. (1007 aa)
	hrob	Uncharacterized protein. (685 aa)
	LOC102682241	ANK_REP_REGION domain-containing protein. (166 aa)
	tk1	Thymidine kinase. (242 aa)
	wrnip1	WRN helicase interacting protein 1. (612 aa)
	W5N7F3_LEPOC	WD repeat containing, antisense to TP53. (422 aa)
	W5N7S3_LEPOC	Polymerase (DNA directed), gamma 2, accessory subunit. (415 aa)
	W5N8G8_LEPOC	Dyskeratosis congenita 1, dyskerin. (538 aa)
	primpol	Primase and polymerase (DNA-directed). (575 aa)
	polg	Polymerase (DNA directed), gamma. (1200 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa)
	W5NDT9_LEPOC	Polymerase (DNA directed), mu. (764 aa)
	polb	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
	W5NFE6_LEPOC	Polymerase (DNA directed), eta. (645 aa)
	W5NFJ7_LEPOC	SprT-like N-terminal domain. (603 aa)
	W5NFW0_LEPOC	Protection of telomeres 1 homolog. (774 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (667 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (348 aa)
	W5NK42_LEPOC	REV3 like, DNA directed polymerase zeta catalytic subunit. (3084 aa)
	ccn2	Cellular communication network factor 2a. (353 aa)
	W5NKD0_LEPOC	Reverse transcriptase domain-containing protein. (1102 aa)
	W5NLC2_LEPOC	Uncharacterized protein. (278 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (697 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTT	W5LXJ3_LEPOC	ENSLOCP00000008791	ENSLOCP00000000850	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA_pol_B domain-containing protein.	0.638
DNTT	W5M103_LEPOC	ENSLOCP00000008791	ENSLOCP00000002060	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.794
DNTT	W5MR27_LEPOC	ENSLOCP00000008791	ENSLOCP00000010836	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.784
DNTT	W5MXW8_LEPOC	ENSLOCP00000008791	ENSLOCP00000013227	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	WRN RecQ like helicase.	0.436
DNTT	W5NK42_LEPOC	ENSLOCP00000008791	ENSLOCP00000021001	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.609
DNTT	lig3	ENSLOCP00000008791	ENSLOCP00000002469	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.722
DNTT	pcna	ENSLOCP00000008791	ENSLOCP00000019251	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.654
DNTT	pola1	ENSLOCP00000008791	ENSLOCP00000002197	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase.	0.469
DNTT	polb	ENSLOCP00000008791	ENSLOCP00000019231	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.692
DNTT	pold2	ENSLOCP00000008791	ENSLOCP00000018670	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.462
DNTT	pole	ENSLOCP00000008791	ENSLOCP00000004785	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.597
DNTT	pole2	ENSLOCP00000008791	ENSLOCP00000014050	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.420
DNTT	poll	ENSLOCP00000008791	ENSLOCP00000014390	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.677
DNTT	rpa1	ENSLOCP00000008791	ENSLOCP00000007742	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.566
GAR1	LOC107080026	ENSLOCP00000014394	ENSLOCP00000008285	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Uncharacterized protein.	0.644
GAR1	W5LZH0_LEPOC	ENSLOCP00000014394	ENSLOCP00000001527	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	HTH myb-type domain-containing protein.	0.422
GAR1	W5M709_LEPOC	ENSLOCP00000014394	ENSLOCP00000004167	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.868
GAR1	W5N7F3_LEPOC	ENSLOCP00000014394	ENSLOCP00000016562	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	WD repeat containing, antisense to TP53.	0.988
GAR1	W5N8G8_LEPOC	ENSLOCP00000014394	ENSLOCP00000016927	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Dyskeratosis congenita 1, dyskerin.	0.999
GAR1	W5NFW0_LEPOC	ENSLOCP00000014394	ENSLOCP00000019519	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	Protection of telomeres 1 homolog.	0.832