(87 nodes) Late endosome network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6b. (864 aa)
	smim22	Small integral membrane protein 22. (82 aa)
	rmc1	Regulator of MON1-CCZ1. (655 aa)
	laptm4a	Lysosomal protein transmembrane 4 alpha. (238 aa)
	tmem9b	TMEM9 domain family, member B. (197 aa)
	rab27b	RAB27B, member RAS oncogene family. (223 aa)
	LOC102683058	Lipopolysaccharide-induced TNF factor. (157 aa)
	W5M9A5_LEPOC	Ankyrin repeat domain 13A. (599 aa)
	cd63	Tetraspanin. (245 aa)
	SLC30A2	Solute carrier family 30 member 2. (384 aa)
	atp13a3	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1270 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (324 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (400 aa)
	W5MGE8_LEPOC	Sortilin-related receptor, L(DLR class) A repeats containing. (2042 aa)
	bace1	Beta-secretase 1; Belongs to the peptidase A1 family. (520 aa)
	W5MGP6_LEPOC	Si:ch211-157c3.4. (157 aa)
	wdr81	WD repeat domain 81. (2071 aa)
	W5MHR7_LEPOC	Ankyrin repeat domain 13B. (630 aa)
	W5MI39_LEPOC	Mucolipin 1a. (577 aa)
	ubxn6	UBX domain protein 6. (437 aa)
	chmp4b	Charged multivesicular body protein 4Ba. (164 aa)
	W5ML93_LEPOC	LITAF domain-containing protein. (211 aa)
	cdip1	Cell death-inducing p53 target 1. (204 aa)
	W5MM41_LEPOC	ATPase cation transporting 13A2. (1095 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (164 aa)
	smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a. (1603 aa)
	tmem192	Transmembrane protein 192. (251 aa)
	W5MNR5_LEPOC	Ankyrin repeat domain 13 family, member D. (260 aa)
	ccz1	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated. (518 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (517 aa)
	lamtor2	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
	SNX14	Sorting nexin 14. (959 aa)
	W5NJH2_LEPOC	Kinase D-interacting substrate 220b. (1772 aa)
	CST7	Cystatin F. (132 aa)
	W5NJC4_LEPOC	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (99 aa)
	abcc10	ATP-binding cassette, sub-family C (CFTR/MRP), member 10. (1539 aa)
	dact2	Dishevelled-binding antagonist of beta-catenin 2. (827 aa)
	slc30a3	Solute carrier family 30 member 2. (400 aa)
	W5NF24_LEPOC	Uncharacterized protein. (283 aa)
	W5NEG0_LEPOC	Cytochrome b561 family, member A3b. (262 aa)
	slc39a14	Solute carrier family 39 member 14. (485 aa)
	LOC102689032	Vesicle-associated membrane protein 5. (89 aa)
	W5NCW6_LEPOC	Charged multivesicular body protein 7. (460 aa)
	chmp1b	Chromatin modifying protein 1B. (231 aa)
	nkpd1	NTPase, KAP family P-loop domain containing 1. (729 aa)
	mon1b	MON1 secretory trafficking family member Bb. (623 aa)
	slc39a9	Solute carrier family 39 member 9. (308 aa)
	clg2h9orf85	Zgc:101016. (195 aa)
	dennd10	DENN domain containing 10. (356 aa)
	laptm4b	Lysosomal protein transmembrane 4 beta. (214 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (189 aa)
	ankrd13c	Ankyrin repeat domain 13C. (525 aa)
	chmp2b	Charged multivesicular body protein 2Bb. (225 aa)
	LOC102688110	Uncharacterized protein. (292 aa)
	chmp3	Charged multivesicular body protein 3. (221 aa)
	vti1b	Vesicle transport through interaction with t-SNAREs 1B. (229 aa)
	W5N983_LEPOC	Hepatocyte growth factor-regulated tyrosine kinase substrate. (775 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	rab27a	RAB27A, member RAS oncogene family. (223 aa)
	W5N726_LEPOC	Ecm29 proteasome adaptor and scaffold. (1848 aa)
	W5N6W8_LEPOC	Uncharacterized protein. (287 aa)
	W5N6V2_LEPOC	Syntaxin 8. (185 aa)
	vipas39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (493 aa)
	slc30a4	Solute carrier family 30 member 4. (435 aa)
	fyco1	FYVE and coiled-coil domain containing 1a. (1540 aa)
	chmp6	Charged multivesicular body protein 6b. (204 aa)
	LOC102697058	Zgc:91968. (240 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	clg9h7orf25	Zgc:55781. (381 aa)
	chmp4c	Charged multivesicular body protein 4C. (159 aa)
	atl1	Atlastin GTPase 1. (560 aa)
	lamtor5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
	lamtor3	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
	tmem9	Transmembrane protein 9. (195 aa)
	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1600 aa)
	chmp5	Charged multivesicular body protein 5a. (222 aa)
	W5MZ12_LEPOC	Uncharacterized protein. (189 aa)
	mon1a	MON1 secretory trafficking family member A. (525 aa)
	W5MY75_LEPOC	Solute carrier family 38 member 9. (536 aa)
	vta1	Vesicle (multivesicular body) trafficking 1. (302 aa)
	LOC102696688	Uncharacterized protein. (269 aa)
	LOC102697903	LITAF domain-containing protein. (166 aa)
	chmp1a	Charged multivesicular body protein 1A. (198 aa)
	LDLRAD1	Low density lipoprotein receptor class A domain containing 1. (200 aa)
	tmem59	Transmembrane protein 59. (331 aa)
	slc30a8	Solute carrier family 30 member 8. (381 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (373 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LDLRAD1	tmem59	ENSLOCP00000003766	ENSLOCP00000003793	Low density lipoprotein receptor class A domain containing 1.	Transmembrane protein 59.	0.432
LOC102683058	W5MGP6_LEPOC	ENSLOCP00000004958	ENSLOCP00000007555	Lipopolysaccharide-induced TNF factor.	Si:ch211-157c3.4.	0.750
LOC102683058	W5ML93_LEPOC	ENSLOCP00000004958	ENSLOCP00000009152	Lipopolysaccharide-induced TNF factor.	LITAF domain-containing protein.	0.713
LOC102683058	cdip1	ENSLOCP00000004958	ENSLOCP00000009216	Lipopolysaccharide-induced TNF factor.	Cell death-inducing p53 target 1.	0.683
LOC102688110	psap	ENSLOCP00000013118	ENSLOCP00000010530	Uncharacterized protein.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.471
LOC102689032	RAB7B	ENSLOCP00000018902	ENSLOCP00000015662	Vesicle-associated membrane protein 5.	RAB7B, member RAS oncogene family.	0.496
LOC102689032	W5MGE8_LEPOC	ENSLOCP00000018902	ENSLOCP00000007457	Vesicle-associated membrane protein 5.	Sortilin-related receptor, L(DLR class) A repeats containing.	0.621
LOC102689032	W5N6V2_LEPOC	ENSLOCP00000018902	ENSLOCP00000016361	Vesicle-associated membrane protein 5.	Syntaxin 8.	0.928
LOC102689032	W5N983_LEPOC	ENSLOCP00000018902	ENSLOCP00000017192	Vesicle-associated membrane protein 5.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.448
LOC102689032	vti1b	ENSLOCP00000018902	ENSLOCP00000017475	Vesicle-associated membrane protein 5.	Vesicle transport through interaction with t-SNAREs 1B.	0.932
LOC102696688	psap	ENSLOCP00000000630	ENSLOCP00000010530	Uncharacterized protein.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.471
LOC102697903	W5MGP6_LEPOC	ENSLOCP00000003494	ENSLOCP00000007555	LITAF domain-containing protein.	Si:ch211-157c3.4.	0.760
LOC102697903	W5ML93_LEPOC	ENSLOCP00000003494	ENSLOCP00000009152	LITAF domain-containing protein.	LITAF domain-containing protein.	0.784
LOC102697903	cdip1	ENSLOCP00000003494	ENSLOCP00000009216	LITAF domain-containing protein.	Cell death-inducing p53 target 1.	0.757
RAB7B	LOC102689032	ENSLOCP00000015662	ENSLOCP00000018902	RAB7B, member RAS oncogene family.	Vesicle-associated membrane protein 5.	0.496
RAB7B	W5N6V2_LEPOC	ENSLOCP00000015662	ENSLOCP00000016361	RAB7B, member RAS oncogene family.	Syntaxin 8.	0.592
RAB7B	ccz1	ENSLOCP00000015662	ENSLOCP00000010388	RAB7B, member RAS oncogene family.	CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.	0.883
RAB7B	fyco1	ENSLOCP00000015662	ENSLOCP00000015949	RAB7B, member RAS oncogene family.	FYVE and coiled-coil domain containing 1a.	0.862
RAB7B	mon1a	ENSLOCP00000015662	ENSLOCP00000013349	RAB7B, member RAS oncogene family.	MON1 secretory trafficking family member A.	0.797
RAB7B	mon1b	ENSLOCP00000015662	ENSLOCP00000017853	RAB7B, member RAS oncogene family.	MON1 secretory trafficking family member Bb.	0.797