STRINGSTRING
LOC102697986 LOC102697986 rad1 rad1 rpa3 rpa3 W5MWB9_LEPOC W5MWB9_LEPOC orc2 orc2 W5MSA1_LEPOC W5MSA1_LEPOC LOC102685849 LOC102685849 rfc3 rfc3 W5MNX2_LEPOC W5MNX2_LEPOC atr atr rad9b rad9b rpa1 rpa1 orc1 orc1 mcm4 mcm4 orc6 orc6 cdc7 cdc7 W5M9K5_LEPOC W5M9K5_LEPOC CDK2 CDK2 rfc5 rfc5 rpa2 rpa2 cdc45 cdc45 orc4 orc4 CDC25B CDC25B chek1 chek1 rfc2 rfc2 rfc4 rfc4 LOC102695737 LOC102695737 mcm6 mcm6 CLSPN CLSPN HUS1 HUS1 cdc6 cdc6 mcm2 mcm2 W5N8T9_LEPOC W5N8T9_LEPOC W5NEJ3_LEPOC W5NEJ3_LEPOC mcm10 mcm10 W5NG96_LEPOC W5NG96_LEPOC mcm8 mcm8 W5NJX2_LEPOC W5NJX2_LEPOC mcm7 mcm7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102697986DNA helicase; Belongs to the MCM family. (814 aa)
rad1RAD1 homolog (S. pombe). (281 aa)
rpa3Replication protein A3. (121 aa)
W5MWB9_LEPOCDBF4 zinc finger. (622 aa)
orc2Origin recognition complex, subunit 2. (576 aa)
W5MSA1_LEPOCRegulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa)
LOC102685849Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
W5MNX2_LEPOCUncharacterized protein. (298 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa)
rad9bRAD9 checkpoint clamp component B. (290 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa)
mcm4DNA helicase; Belongs to the MCM family. (678 aa)
orc6Origin recognition complex, subunit 6. (256 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (545 aa)
W5M9K5_LEPOCRAD17 checkpoint clamp loader component. (584 aa)
CDK2Cyclin dependent kinase 2. (252 aa)
rfc5Replication factor C (activator 1) 5. (367 aa)
rpa2Replication protein A2. (277 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
CDC25BCell division cycle 25B. (574 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
rfc2Replication factor C (activator 1) 2. (358 aa)
rfc4Replication factor C (activator 1) 4. (359 aa)
LOC102695737DNA helicase; Belongs to the MCM family. (834 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
CLSPNClaspin. (1303 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
W5N8T9_LEPOCATR interacting protein. (763 aa)
W5NEJ3_LEPOCOrigin recognition complex, subunit 5. (375 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (867 aa)
W5NG96_LEPOCDNA helicase; Belongs to the MCM family. (815 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
W5NJX2_LEPOCOrigin recognition complex, subunit 3. (728 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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