STRINGSTRING
rad51 rad51 rfc3 rfc3 W5MNK3_LEPOC W5MNK3_LEPOC mre11 mre11 recql4 recql4 rpa1 rpa1 SPIDR SPIDR W5MEG4_LEPOC W5MEG4_LEPOC W5MEE1_LEPOC W5MEE1_LEPOC W5MDZ8_LEPOC W5MDZ8_LEPOC W5MDS2_LEPOC W5MDS2_LEPOC meiob meiob top3a top3a tdrd3 tdrd3 rfc1 rfc1 LOC102696624 LOC102696624 exd2 exd2 rad51b rad51b blm blm W5ND91_LEPOC W5ND91_LEPOC pold2 pold2 rps27a rps27a pcna pcna W5NFE6_LEPOC W5NFE6_LEPOC W5NIU6_LEPOC W5NIU6_LEPOC RAD51AP1 RAD51AP1 GEN1 GEN1 rmi1 rmi1 W5LXJ3_LEPOC W5LXJ3_LEPOC mus81 mus81 rfc4 rfc4 rfc2 rfc2 chek1 chek1 W5LZC5_LEPOC W5LZC5_LEPOC W5LZK6_LEPOC W5LZK6_LEPOC RBBP8 RBBP8 rad51d rad51d uba52 uba52 EME2 EME2 pold3 pold3 pole3 pole3 W5M3S0_LEPOC W5M3S0_LEPOC W5M4D7_LEPOC W5M4D7_LEPOC rpa2 rpa2 rfc5 rfc5 pole4 pole4 pole pole rmi2 rmi2 LOC102685849 LOC102685849 W5MSA1_LEPOC W5MSA1_LEPOC DNA2 DNA2 W5MUV7_LEPOC W5MUV7_LEPOC W5MW35_LEPOC W5MW35_LEPOC rad50 rad50 W5MXW8_LEPOC W5MXW8_LEPOC eme1 eme1 rpa3 rpa3 W5N048_LEPOC W5N048_LEPOC pole2 pole2 XRCC2 XRCC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
W5MNK3_LEPOCTower domain-containing protein. (871 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (725 aa)
recql4RecQ helicase-like 4. (1459 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
SPIDRScaffold protein involved in DNA repair. (961 aa)
W5MEG4_LEPOCUncharacterized protein. (536 aa)
W5MEE1_LEPOCPALB2_WD40 domain-containing protein. (122 aa)
W5MDZ8_LEPOCPolymerase (DNA directed) kappa. (839 aa)
W5MDS2_LEPOCANK_REP_REGION domain-containing protein. (1588 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa)
tdrd3Tudor domain containing 3. (743 aa)
rfc1Replication factor C subunit 1. (1204 aa)
LOC102696624Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa)
exd2Exonuclease 3'-5' domain containing 2. (613 aa)
rad51bRAD51 paralog B. (384 aa)
blmBLM RecQ like helicase. (1481 aa)
W5ND91_LEPOCUncharacterized protein. (96 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa)
rps27aRibosomal protein S27a. (162 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
W5NFE6_LEPOCPolymerase (DNA directed), eta. (645 aa)
W5NIU6_LEPOCExonuclease 1. (797 aa)
RAD51AP1RAD51 associated protein 1. (355 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (461 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (627 aa)
W5LXJ3_LEPOCDNA_pol_B domain-containing protein. (97 aa)
mus81MUS81 structure-specific endonuclease subunit. (616 aa)
rfc4Replication factor C (activator 1) 4. (359 aa)
rfc2Replication factor C (activator 1) 2. (358 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
W5LZC5_LEPOCRAD51 paralog C. (374 aa)
W5LZK6_LEPOCNon-specific serine/threonine protein kinase. (3061 aa)
RBBP8Uncharacterized protein. (865 aa)
rad51dDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (336 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (472 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
W5M3S0_LEPOCAnkyrin repeat domain 12. (2028 aa)
W5M4D7_LEPOCSLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1669 aa)
rpa2Replication protein A2. (277 aa)
rfc5Replication factor C (activator 1) 5. (367 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
rmi2RecQ mediated genome instability 2. (154 aa)
LOC102685849Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
W5MSA1_LEPOCRegulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa)
DNA2DNA replication helicase/nuclease 2. (1397 aa)
W5MUV7_LEPOCDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa)
W5MW35_LEPOCNibrin. (846 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
W5MXW8_LEPOCWRN RecQ like helicase. (1464 aa)
eme1Essential meiotic structure-specific endonuclease 1. (590 aa)
rpa3Replication protein A3. (121 aa)
W5N048_LEPOCUncharacterized protein. (1423 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
XRCC2X-ray repair cross complementing 2. (285 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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