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rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) | ||||
rfc3 | Replication factor C (activator 1) 3. (356 aa) | ||||
W5MNK3_LEPOC | Tower domain-containing protein. (871 aa) | ||||
mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (725 aa) | ||||
recql4 | RecQ helicase-like 4. (1459 aa) | ||||
rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) | ||||
SPIDR | Scaffold protein involved in DNA repair. (961 aa) | ||||
W5MEG4_LEPOC | Uncharacterized protein. (536 aa) | ||||
W5MEE1_LEPOC | PALB2_WD40 domain-containing protein. (122 aa) | ||||
W5MDZ8_LEPOC | Polymerase (DNA directed) kappa. (839 aa) | ||||
W5MDS2_LEPOC | ANK_REP_REGION domain-containing protein. (1588 aa) | ||||
meiob | Methionine sulfoxide reductase B1b. (471 aa) | ||||
top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa) | ||||
tdrd3 | Tudor domain containing 3. (743 aa) | ||||
rfc1 | Replication factor C subunit 1. (1204 aa) | ||||
LOC102696624 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) | ||||
exd2 | Exonuclease 3'-5' domain containing 2. (613 aa) | ||||
rad51b | RAD51 paralog B. (384 aa) | ||||
blm | BLM RecQ like helicase. (1481 aa) | ||||
W5ND91_LEPOC | Uncharacterized protein. (96 aa) | ||||
pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa) | ||||
rps27a | Ribosomal protein S27a. (162 aa) | ||||
pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa) | ||||
W5NFE6_LEPOC | Polymerase (DNA directed), eta. (645 aa) | ||||
W5NIU6_LEPOC | Exonuclease 1. (797 aa) | ||||
RAD51AP1 | RAD51 associated protein 1. (355 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (461 aa) | ||||
rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (627 aa) | ||||
W5LXJ3_LEPOC | DNA_pol_B domain-containing protein. (97 aa) | ||||
mus81 | MUS81 structure-specific endonuclease subunit. (616 aa) | ||||
rfc4 | Replication factor C (activator 1) 4. (359 aa) | ||||
rfc2 | Replication factor C (activator 1) 2. (358 aa) | ||||
chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) | ||||
W5LZC5_LEPOC | RAD51 paralog C. (374 aa) | ||||
W5LZK6_LEPOC | Non-specific serine/threonine protein kinase. (3061 aa) | ||||
RBBP8 | Uncharacterized protein. (865 aa) | ||||
rad51d | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (336 aa) | ||||
uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa) | ||||
EME2 | Essential meiotic structure-specific endonuclease subunit 2. (472 aa) | ||||
pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa) | ||||
pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) | ||||
W5M3S0_LEPOC | Ankyrin repeat domain 12. (2028 aa) | ||||
W5M4D7_LEPOC | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1669 aa) | ||||
rpa2 | Replication protein A2. (277 aa) | ||||
rfc5 | Replication factor C (activator 1) 5. (367 aa) | ||||
pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa) | ||||
pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa) | ||||
rmi2 | RecQ mediated genome instability 2. (154 aa) | ||||
LOC102685849 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) | ||||
W5MSA1_LEPOC | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1397 aa) | ||||
W5MUV7_LEPOC | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) | ||||
W5MW35_LEPOC | Nibrin. (846 aa) | ||||
rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) | ||||
W5MXW8_LEPOC | WRN RecQ like helicase. (1464 aa) | ||||
eme1 | Essential meiotic structure-specific endonuclease 1. (590 aa) | ||||
rpa3 | Replication protein A3. (121 aa) | ||||
W5N048_LEPOC | Uncharacterized protein. (1423 aa) | ||||
pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) | ||||
XRCC2 | X-ray repair cross complementing 2. (285 aa) |