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| | W5MW35_LEPOC | Nibrin. (846 aa) |
| | sumo1 | Small ubiquitin-related modifier. (101 aa) |
| | rhno1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (290 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (475 aa) |
| | eya4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (660 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1009 aa) |
| | W5NFE6_LEPOC | Polymerase (DNA directed), eta. (645 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa) |
| | rps27a | Ribosomal protein S27a. (162 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (418 aa) |
| | LOC102686492 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | W5MUV7_LEPOC | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | W5MSA1_LEPOC | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa) |
| | tdp1 | Tyrosyl-DNA phosphodiesterase 1. (611 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1028 aa) |
| | LOC102685849 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | W5MR27_LEPOC | DNA ligase. (924 aa) |
| | tmem182 | Transmembrane protein 182b. (246 aa) |
| | W5MPK4_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (151 aa) |
| | W5MPI1_LEPOC | Cyclin A1; Belongs to the cyclin family. (401 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | W5MNX2_LEPOC | Uncharacterized protein. (298 aa) |
| | W5MNK3_LEPOC | Tower domain-containing protein. (871 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (725 aa) |
| | recql4 | RecQ helicase-like 4. (1459 aa) |
| | W5ML00_LEPOC | Cell division cycle associated 7a. (393 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (290 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (494 aa) |
| | W5MJK0_LEPOC | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1380 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | W5MGG9_LEPOC | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (445 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (961 aa) |
| | W5MG32_LEPOC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4160 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | W5MFP2_LEPOC | Protein inhibitor of activated STAT, 4a. (489 aa) |
| | tdp2 | Tyrosyl-DNA phosphodiesterase 2b. (279 aa) |
| | W5MET7_LEPOC | Polymerase (DNA directed), theta. (2592 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (648 aa) |
| | W5MEG4_LEPOC | Uncharacterized protein. (536 aa) |
| | W5MEE1_LEPOC | PALB2_WD40 domain-containing protein. (122 aa) |
| | W5MDZ8_LEPOC | Polymerase (DNA directed) kappa. (839 aa) |
| | W5MDS2_LEPOC | ANK_REP_REGION domain-containing protein. (1588 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (471 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa) |
| | tdrd3 | Tudor domain containing 3. (743 aa) |
| | LOC102695679 | Importin subunit alpha; Belongs to the importin alpha family. (519 aa) |
| | W5M9S6_LEPOC | XPGI domain-containing protein. (345 aa) |
| | W5M9K5_LEPOC | RAD17 checkpoint clamp loader component. (584 aa) |
| | eya3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (632 aa) |
| | timeless | Timeless circadian clock. (1225 aa) |
| | rmi2 | RecQ mediated genome instability 2. (154 aa) |
| | CDK2 | Cyclin dependent kinase 2. (252 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa) |
| | eya1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa) |
| | chek2 | Checkpoint kinase 2. (518 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (162 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (367 aa) |
| | rpa2 | Replication protein A2. (277 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (434 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (347 aa) |
| | W5M4D7_LEPOC | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1669 aa) |
| | W5M443_LEPOC | Replication timing regulatory factor 1. (2179 aa) |
| | W5M3S0_LEPOC | Ankyrin repeat domain 12. (2028 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (472 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (627 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (463 aa) |
| | xrcc5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (727 aa) |
| | apbb1 | Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (710 aa) |
| | pwwp2a | PWWP domain containing 2A. (672 aa) |
| | sumo3 | Small ubiquitin-related modifier. (94 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1397 aa) |
| | W5NEB6_LEPOC | Reverse transcriptase domain-containing protein. (596 aa) |
| | LOC102699233 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | W5NLL5_LEPOC | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (461 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | W5NK64_LEPOC | Uncharacterized protein. (133 aa) |
| | W5NK63_LEPOC | Uncharacterized protein. (163 aa) |
| | dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (671 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | W5NIU6_LEPOC | Exonuclease 1. (797 aa) |
| | kdm4b | Lysine (K)-specific demethylase 4B. (1439 aa) |
| | W5LVZ4_LEPOC | Poly [ADP-ribose] polymerase. (480 aa) |
| | W5LWC3_LEPOC | PINIT domain-containing protein. (82 aa) |
| | W5LWH6_LEPOC | Reverse transcriptase domain-containing protein. (823 aa) |
| | W5LWT0_LEPOC | Reverse transcriptase domain-containing protein. (604 aa) |
| | W5LXJ3_LEPOC | DNA_pol_B domain-containing protein. (97 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (616 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (358 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | W5LY98_LEPOC | Bromodomain adjacent to zinc finger domain, 1B. (1632 aa) |
| | W5LZC5_LEPOC | RAD51 paralog C. (374 aa) |
| | W5LZK6_LEPOC | Non-specific serine/threonine protein kinase. (3061 aa) |
| | W5M0D4_LEPOC | SMC5-SMC6 complex localization factor 1. (858 aa) |
| | RBBP8 | Uncharacterized protein. (865 aa) |
| | xrcc4 | X-ray repair complementing defective repair in Chinese hamster cells 4. (339 aa) |
| | rad51d | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (336 aa) |
| | lig3 | DNA ligase. (1001 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa) |
| | W5M2L3_LEPOC | Ring finger protein 169. (462 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (173 aa) |
| | W5NDT9_LEPOC | Polymerase (DNA directed), mu. (764 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa) |
| | W5ND91_LEPOC | Uncharacterized protein. (96 aa) |
| | W5NC99_LEPOC | Serine/threonine-protein phosphatase. (751 aa) |
| | smarca1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1038 aa) |
| | blm | BLM RecQ like helicase. (1481 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1964 aa) |
| | rad51b | RAD51 paralog B. (384 aa) |
| | W5N933_LEPOC | Reverse transcriptase domain-containing protein. (704 aa) |
| | W5N8X8_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (323 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa) |
| | W5N8T9_LEPOC | ATR interacting protein. (763 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (262 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (613 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | LOC102696624 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) |
| | rfc1 | Replication factor C subunit 1. (1204 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) |
| | sirt7 | Sirtuin 7. (437 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (285 aa) |
| | paxip1 | PAX interacting (with transcription-activation domain) protein 1. (1131 aa) |
| | W5N3D9_LEPOC | Uncharacterized protein. (465 aa) |
| | W5N2Q8_LEPOC | Abraxas 1, BRCA1 A complex subunit. (411 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1514 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (579 aa) |
| | W5N0L4_LEPOC | X-ray repair complementing defective repair in Chinese hamster cells 6. (502 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | W5N048_LEPOC | Uncharacterized protein. (1423 aa) |
| | W5MZ98_LEPOC | UBIQUITIN_CONJUGAT_2 domain-containing protein. (66 aa) |
| | LOC102683539 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (120 aa) |
| | rpa3 | Replication protein A3. (121 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (590 aa) |
| | cnppd1 | Cyclin Pas1/PHO80 domain containing 1. (428 aa) |
| | W5MY70_LEPOC | Solute carrier family 23 member 3. (539 aa) |
| | nhej1 | Nonhomologous end-joining factor 1. (317 aa) |
| | W5MXW8_LEPOC | WRN RecQ like helicase. (1464 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (516 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
