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| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (627 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1009 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (475 aa) |
| | rhno1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (290 aa) |
| | W5NIU6_LEPOC | Exonuclease 1. (797 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (355 aa) |
| | W5NK63_LEPOC | Uncharacterized protein. (163 aa) |
| | W5NK64_LEPOC | Uncharacterized protein. (133 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (461 aa) |
| | W5NLL5_LEPOC | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | LOC102699233 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC102686492 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | W5LVZ4_LEPOC | Poly [ADP-ribose] polymerase. (480 aa) |
| | W5LWC3_LEPOC | PINIT domain-containing protein. (82 aa) |
| | W5LWH6_LEPOC | Reverse transcriptase domain-containing protein. (823 aa) |
| | W5LWT0_LEPOC | Reverse transcriptase domain-containing protein. (604 aa) |
| | W5LXJ3_LEPOC | DNA_pol_B domain-containing protein. (97 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (616 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (358 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | W5LZC5_LEPOC | RAD51 paralog C. (374 aa) |
| | W5LZK6_LEPOC | Non-specific serine/threonine protein kinase. (3061 aa) |
| | W5M0D4_LEPOC | SMC5-SMC6 complex localization factor 1. (858 aa) |
| | RBBP8 | Uncharacterized protein. (865 aa) |
| | rad51d | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (336 aa) |
| | lig3 | DNA ligase. (1001 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa) |
| | W5M2L3_LEPOC | Ring finger protein 169. (462 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (472 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) |
| | W5M3S0_LEPOC | Ankyrin repeat domain 12. (2028 aa) |
| | W5M4D7_LEPOC | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1669 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (347 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (434 aa) |
| | rpa2 | Replication protein A2. (277 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (367 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (162 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa) |
| | CDK2 | Cyclin dependent kinase 2. (252 aa) |
| | rmi2 | RecQ mediated genome instability 2. (154 aa) |
| | timeless | Timeless circadian clock. (1225 aa) |
| | W5M9K5_LEPOC | RAD17 checkpoint clamp loader component. (584 aa) |
| | W5M9S6_LEPOC | XPGI domain-containing protein. (345 aa) |
| | tdrd3 | Tudor domain containing 3. (743 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (471 aa) |
| | W5MDS2_LEPOC | ANK_REP_REGION domain-containing protein. (1588 aa) |
| | W5MDZ8_LEPOC | Polymerase (DNA directed) kappa. (839 aa) |
| | W5MEE1_LEPOC | PALB2_WD40 domain-containing protein. (122 aa) |
| | W5MEG4_LEPOC | Uncharacterized protein. (536 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (648 aa) |
| | W5MET7_LEPOC | Polymerase (DNA directed), theta. (2592 aa) |
| | W5MFP2_LEPOC | Protein inhibitor of activated STAT, 4a. (489 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (961 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1380 aa) |
| | W5MJK0_LEPOC | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (290 aa) |
| | W5ML00_LEPOC | Cell division cycle associated 7a. (393 aa) |
| | recql4 | RecQ helicase-like 4. (1459 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (725 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa) |
| | W5MNK3_LEPOC | Tower domain-containing protein. (871 aa) |
| | W5MNX2_LEPOC | Uncharacterized protein. (298 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | W5MPI1_LEPOC | Cyclin A1; Belongs to the cyclin family. (401 aa) |
| | W5MPK4_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (151 aa) |
| | LOC102685849 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | W5MSA1_LEPOC | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1397 aa) |
| | sumo3 | Small ubiquitin-related modifier. (94 aa) |
| | pwwp2a | PWWP domain containing 2A. (672 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (463 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (418 aa) |
| | W5MUV7_LEPOC | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | W5MW35_LEPOC | Nibrin. (846 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (516 aa) |
| | W5MXW8_LEPOC | WRN RecQ like helicase. (1464 aa) |
| | eme1 | Essential meiotic structure-specific endonuclease 1. (590 aa) |
| | rpa3 | Replication protein A3. (121 aa) |
| | LOC102683539 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (120 aa) |
| | W5MZ98_LEPOC | UBIQUITIN_CONJUGAT_2 domain-containing protein. (66 aa) |
| | W5N048_LEPOC | Uncharacterized protein. (1423 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1514 aa) |
| | W5N2Q8_LEPOC | Abraxas 1, BRCA1 A complex subunit. (411 aa) |
| | W5N3D9_LEPOC | Uncharacterized protein. (465 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (285 aa) |
| | sirt7 | Sirtuin 7. (437 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) |
| | rfc1 | Replication factor C subunit 1. (1204 aa) |
| | LOC102696624 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (613 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (262 aa) |
| | W5N8T9_LEPOC | ATR interacting protein. (763 aa) |
| | W5N8X8_LEPOC | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (323 aa) |
| | W5N933_LEPOC | Reverse transcriptase domain-containing protein. (704 aa) |
| | rad51b | RAD51 paralog B. (384 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1964 aa) |
| | blm | BLM RecQ like helicase. (1481 aa) |
| | W5ND91_LEPOC | Uncharacterized protein. (96 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (173 aa) |
| | W5NEB6_LEPOC | Reverse transcriptase domain-containing protein. (596 aa) |
| | rps27a | Ribosomal protein S27a. (162 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa) |
| | W5NFE6_LEPOC | Polymerase (DNA directed), eta. (645 aa) |
