STRINGSTRING
psmb1 psmb1 rps27a rps27a mcm10 mcm10 W5NG96_LEPOC W5NG96_LEPOC psmc2 psmc2 mcm8 mcm8 wee2 wee2 cdkn1b cdkn1b W5NJX2_LEPOC W5NJX2_LEPOC prim2 prim2 mcm9 mcm9 W5NA30_LEPOC W5NA30_LEPOC psmd10 psmd10 LOC102683700 LOC102683700 W5LXB1_LEPOC W5LXB1_LEPOC psmb2 psmb2 W5LXK8_LEPOC W5LXK8_LEPOC mcm6 mcm6 LOC102682951 LOC102682951 W5LYH4_LEPOC W5LYH4_LEPOC CDC25B CDC25B W5LZH3_LEPOC W5LZH3_LEPOC orc4 orc4 cables1 cables1 cdc45 cdc45 pola1 pola1 ccnh ccnh uba52 uba52 psmd13 psmd13 PPP2R3B PPP2R3B PPP4R1 PPP4R1 pole3 pole3 W5M4G9_LEPOC W5M4G9_LEPOC W5M4I8_LEPOC W5M4I8_LEPOC ccna2 ccna2 rpa2 rpa2 psma1 psma1 psmd5 psmd5 LOC107079691 LOC107079691 pole4 pole4 wee1 wee1 cdk4 cdk4 psmd7 psmd7 pole pole CDK2 CDK2 gmnn gmnn psmd1 psmd1 W5MBI2_LEPOC W5MBI2_LEPOC cdc7 cdc7 psmc4 psmc4 ccnd1 ccnd1 meiob meiob ptk6 ptk6 psmb7 psmb7 psmd9 psmd9 cables2 cables2 orc6 orc6 ccne1 ccne1 W5MEY6_LEPOC W5MEY6_LEPOC rbbp8nl rbbp8nl mcm4 mcm4 cdk7 cdk7 fnbp4 fnbp4 psmc3 psmc3 orc1 orc1 ccne2 ccne2 rpa1 rpa1 LOC102693453 LOC102693453 prim1 prim1 psmf1 psmf1 ppp2r3a ppp2r3a W5MPI1_LEPOC W5MPI1_LEPOC psmd14 psmd14 psmd2 psmd2 rb1 rb1 W5MRH9_LEPOC W5MRH9_LEPOC psma6 psma6 ppp2r3c ppp2r3c psma2 psma2 psma3 psma3 orc2 orc2 mnat1 mnat1 PPP2CA PPP2CA skp1 skp1 LOC107078820 LOC107078820 LOC107078822 LOC107078822 psmd6 psmd6 W5MWB9_LEPOC W5MWB9_LEPOC ppp2cb ppp2cb rpa3 rpa3 pole2 pole2 LOC102682223 LOC102682223 cks2 cks2 psmc5 psmc5 psmc6 psmc6 LOC102697986 LOC102697986 psme3 psme3 psma5 psma5 cdkn1a cdkn1a skp2 skp2 akt1 akt1 psmd3 psmd3 psmd11 psmd11 ppp4r4 ppp4r4 mcm7 mcm7 LOC102695737 LOC102695737 cul1 cul1 W5N7G0_LEPOC W5N7G0_LEPOC cdc6 cdc6 mcm2 mcm2 psmd12 psmd12 psmb3 psmb3 W5N8D2_LEPOC W5N8D2_LEPOC W5NA15_LEPOC W5NA15_LEPOC akt2 akt2 psma4 psma4 W5ND91_LEPOC W5ND91_LEPOC W5NE85_LEPOC W5NE85_LEPOC W5NEJ3_LEPOC W5NEJ3_LEPOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb1Proteasome subunit beta. (237 aa)
rps27aRibosomal protein S27a. (162 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (867 aa)
W5NG96_LEPOCDNA helicase; Belongs to the MCM family. (815 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
wee2Wee1-like protein kinase. (582 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Ba. (195 aa)
W5NJX2_LEPOCOrigin recognition complex, subunit 3. (728 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (512 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (660 aa)
W5NA30_LEPOCProteasome 26S subunit, non-ATPase 8. (292 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
LOC102683700Uncharacterized protein. (148 aa)
W5LXB1_LEPOCUncharacterized protein. (53 aa)
psmb2Proteasome subunit beta. (200 aa)
W5LXK8_LEPOCUncharacterized protein. (133 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
LOC102682951Cyclin-dependent kinase inhibitor 1Cb. (222 aa)
W5LYH4_LEPOCProteasome activator subunit 1. (161 aa)
CDC25BCell division cycle 25B. (574 aa)
W5LZH3_LEPOCProtein phosphatase 2, regulatory subunit A, beta b. (600 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
cables1Cdk5 and Abl enzyme substrate 1. (539 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
pola1DNA polymerase. (1486 aa)
ccnhCyclin H; Belongs to the cyclin family. (322 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (408 aa)
PPP2R3BEF-hand domain-containing protein. (588 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (932 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
W5M4G9_LEPOCDNA_pol_E_B domain-containing protein. (66 aa)
W5M4I8_LEPOCUncharacterized protein. (168 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
rpa2Replication protein A2. (277 aa)
psma1Proteasome subunit alpha type. (268 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (522 aa)
LOC107079691Chemokine (C-C motif) ligand 44. (115 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa)
wee1Wee1-like protein kinase. (619 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (326 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
CDK2Cyclin dependent kinase 2. (252 aa)
gmnnGeminin DNA replication inhibitor. (223 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
W5MBI2_LEPOCChromatin licensing and DNA replication factor 1. (614 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (545 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (296 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
ptk6Tyrosine-protein kinase. (508 aa)
psmb7Proteasome subunit beta. (284 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (215 aa)
cables2Cdk5 and Abl enzyme substrate 2b. (528 aa)
orc6Origin recognition complex, subunit 6. (256 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (412 aa)
W5MEY6_LEPOCCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
rbbp8nlRetinoblastoma binding protein 8-like. (600 aa)
mcm4DNA helicase; Belongs to the MCM family. (678 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (348 aa)
fnbp4Formin binding protein 4. (1026 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (443 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC102693453WRNPLPNID domain-containing protein. (947 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
psmf1Proteasome inhibitor subunit 1. (305 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1175 aa)
W5MPI1_LEPOCCyclin A1; Belongs to the cyclin family. (401 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (899 aa)
rb1Retinoblastoma 1. (932 aa)
W5MRH9_LEPOCProteasome 26S subunit, ATPase 1a; Belongs to the AAA ATPase family. (441 aa)
psma6Proteasome subunit alpha type. (246 aa)
ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (454 aa)
psma2Proteasome subunit alpha type. (234 aa)
psma3Proteasome subunit alpha type. (255 aa)
orc2Origin recognition complex, subunit 2. (576 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC107078820Uncharacterized protein. (440 aa)
LOC107078822Uncharacterized protein. (810 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
W5MWB9_LEPOCDBF4 zinc finger. (622 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
rpa3Replication protein A3. (121 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC102682223PCI domain-containing protein. (380 aa)
cks2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (404 aa)
LOC102697986DNA helicase; Belongs to the MCM family. (814 aa)
psme3Proteasome activator subunit 3. (258 aa)
psma5Proteasome subunit alpha type. (241 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (156 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (414 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (514 aa)
psmd11Proteasome 26S subunit, non-ATPase 11b. (426 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (860 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa)
LOC102695737DNA helicase; Belongs to the MCM family. (834 aa)
cul1Cullin 1a; Belongs to the cullin family. (777 aa)
W5N7G0_LEPOCRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1125 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (462 aa)
psmb3Proteasome subunit beta. (224 aa)
W5N8D2_LEPOCProteasome subunit beta 6. (225 aa)
W5NA15_LEPOCProteasome endopeptidase complex; Belongs to the peptidase T1A family. (250 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
psma4Proteasome subunit alpha type. (261 aa)
W5ND91_LEPOCUncharacterized protein. (96 aa)
W5NE85_LEPOCNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (469 aa)
W5NEJ3_LEPOCOrigin recognition complex, subunit 5. (375 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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