STRINGSTRING
psmb2 psmb2 anapc2 anapc2 W5LXJ3_LEPOC W5LXJ3_LEPOC W5LXK8_LEPOC W5LXK8_LEPOC mcm6 mcm6 rfc4 rfc4 rfc2 rfc2 gins2 gins2 W5LYH4_LEPOC W5LYH4_LEPOC W5LZJ8_LEPOC W5LZJ8_LEPOC orc4 orc4 W5M103_LEPOC W5M103_LEPOC pola1 pola1 uba52 uba52 pold3 pold3 psmd13 psmd13 pole3 pole3 cdc16 cdc16 W5M4G9_LEPOC W5M4G9_LEPOC W5M4I8_LEPOC W5M4I8_LEPOC ccna2 ccna2 rpa2 rpa2 psma1 psma1 psmd5 psmd5 LOC107079691 LOC107079691 rfc5 rfc5 gins3 gins3 pole4 pole4 PSMA7 PSMA7 psmd7 psmd7 pole pole CDK2 CDK2 W5M9S6_LEPOC W5M9S6_LEPOC gmnn gmnn psmd1 psmd1 W5MBI2_LEPOC W5MBI2_LEPOC psmc4 psmc4 anapc5 anapc5 meiob meiob psmb7 psmb7 psmd9 psmd9 anapc16 anapc16 orc6 orc6 ccne1 ccne1 mcm4 mcm4 psmc3 psmc3 orc1 orc1 psma8 psma8 ccne2 ccne2 rpa1 rpa1 LOC102687731 LOC102687731 ube2c ube2c UBE2E2 UBE2E2 anapc7 anapc7 prim1 prim1 psmf1 psmf1 anapc15 anapc15 rfc3 rfc3 W5MPI1_LEPOC W5MPI1_LEPOC psmd14 psmd14 LOC102685849 LOC102685849 anapc10 anapc10 W5MRH9_LEPOC W5MRH9_LEPOC LOC102697986 LOC102697986 psme3 psme3 psma5 psma5 skp2 skp2 psmd3 psmd3 psmd11 psmd11 rfc1 rfc1 mcm7 mcm7 cdc27 cdc27 LOC102695737 LOC102695737 cul1 cul1 cdc6 cdc6 mcm2 mcm2 psmd12 psmd12 psmb3 psmb3 W5N8D2_LEPOC W5N8D2_LEPOC W5N8N6_LEPOC W5N8N6_LEPOC anapc4 anapc4 W5NA15_LEPOC W5NA15_LEPOC W5NA30_LEPOC W5NA30_LEPOC W5NA38_LEPOC W5NA38_LEPOC W5NA40_LEPOC W5NA40_LEPOC psmd10 psmd10 psma4 psma4 W5ND91_LEPOC W5ND91_LEPOC pold2 pold2 tm7sf3 tm7sf3 W5NEJ3_LEPOC W5NEJ3_LEPOC psmb1 psmb1 W5NEM9_LEPOC W5NEM9_LEPOC W5NEN2_LEPOC W5NEN2_LEPOC rps27a rps27a pcna pcna fam89a fam89a W5NG96_LEPOC W5NG96_LEPOC psmc2 psmc2 gins4 gins4 psme4 psme4 mcm8 mcm8 bicral bicral gins1 gins1 W5NJX2_LEPOC W5NJX2_LEPOC prim2 prim2 mcm9 mcm9 psma6 psma6 W5MSA1_LEPOC W5MSA1_LEPOC DNA2 DNA2 psma2 psma2 psma3 psma3 W5MTM3_LEPOC W5MTM3_LEPOC orc2 orc2 skp1 skp1 psmd6 psmd6 LOC102692087 LOC102692087 rpa3 rpa3 pole2 pole2 LOC102682223 LOC102682223 psmc5 psmc5 psmc6 psmc6 LOC102683700 LOC102683700 cdc26 cdc26 W5LXB1_LEPOC W5LXB1_LEPOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmb2Proteasome subunit beta. (200 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (785 aa)
W5LXJ3_LEPOCDNA_pol_B domain-containing protein. (97 aa)
W5LXK8_LEPOCUncharacterized protein. (133 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
rfc4Replication factor C (activator 1) 4. (359 aa)
rfc2Replication factor C (activator 1) 2. (358 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
W5LYH4_LEPOCProteasome activator subunit 1. (161 aa)
W5LZJ8_LEPOCFizzy/cell division cycle 20 related 1a. (528 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
W5M103_LEPOCDNA ligase. (1030 aa)
pola1DNA polymerase. (1486 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (408 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (629 aa)
W5M4G9_LEPOCDNA_pol_E_B domain-containing protein. (66 aa)
W5M4I8_LEPOCUncharacterized protein. (168 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
rpa2Replication protein A2. (277 aa)
psma1Proteasome subunit alpha type. (268 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (522 aa)
LOC107079691Chemokine (C-C motif) ligand 44. (115 aa)
rfc5Replication factor C (activator 1) 5. (367 aa)
gins3GINS complex subunit 3. (211 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (326 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
CDK2Cyclin dependent kinase 2. (252 aa)
W5M9S6_LEPOCXPGI domain-containing protein. (345 aa)
gmnnGeminin DNA replication inhibitor. (223 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa)
W5MBI2_LEPOCChromatin licensing and DNA replication factor 1. (614 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
anapc5Anaphase promoting complex subunit 5. (769 aa)
meiobMethionine sulfoxide reductase B1b. (471 aa)
psmb7Proteasome subunit beta. (284 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (215 aa)
anapc16Anaphase promoting complex subunit 16. (116 aa)
orc6Origin recognition complex, subunit 6. (256 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (412 aa)
mcm4DNA helicase; Belongs to the MCM family. (678 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (443 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa)
psma8Proteasome subunit alpha type. (251 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC102687731DUF4203 domain-containing protein. (548 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (357 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
anapc7Anaphase promoting complex subunit 7. (567 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
psmf1Proteasome inhibitor subunit 1. (305 aa)
anapc15Anaphase promoting complex subunit 15. (134 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
W5MPI1_LEPOCCyclin A1; Belongs to the cyclin family. (401 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
LOC102685849Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
W5MRH9_LEPOCProteasome 26S subunit, ATPase 1a; Belongs to the AAA ATPase family. (441 aa)
LOC102697986DNA helicase; Belongs to the MCM family. (814 aa)
psme3Proteasome activator subunit 3. (258 aa)
psma5Proteasome subunit alpha type. (241 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (414 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (514 aa)
psmd11Proteasome 26S subunit, non-ATPase 11b. (426 aa)
rfc1Replication factor C subunit 1. (1204 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa)
cdc27Cell division cycle 27. (830 aa)
LOC102695737DNA helicase; Belongs to the MCM family. (834 aa)
cul1Cullin 1a; Belongs to the cullin family. (777 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (462 aa)
psmb3Proteasome subunit beta. (224 aa)
W5N8D2_LEPOCProteasome subunit beta 6. (225 aa)
W5N8N6_LEPOCATPase family AAA domain containing 5a. (1812 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
W5NA15_LEPOCProteasome endopeptidase complex; Belongs to the peptidase T1A family. (250 aa)
W5NA30_LEPOCProteasome 26S subunit, non-ATPase 8. (292 aa)
W5NA38_LEPOCBRD4 interacting chromatin remodeling complex associated protein. (1416 aa)
W5NA40_LEPOCUncharacterized protein. (104 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
psma4Proteasome subunit alpha type. (261 aa)
W5ND91_LEPOCUncharacterized protein. (96 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa)
tm7sf3Transmembrane 7 superfamily member 3. (566 aa)
W5NEJ3_LEPOCOrigin recognition complex, subunit 5. (375 aa)
psmb1Proteasome subunit beta. (237 aa)
W5NEM9_LEPOCAnaphase promoting complex subunit 1. (925 aa)
W5NEN2_LEPOCAnaphase promoting complex subunit 1. (948 aa)
rps27aRibosomal protein S27a. (162 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
fam89aFamily with sequence similarity 89 member A. (182 aa)
W5NG96_LEPOCDNA helicase; Belongs to the MCM family. (815 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (225 aa)
psme4Proteasome activator subunit 4b. (1848 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (1043 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
W5NJX2_LEPOCOrigin recognition complex, subunit 3. (728 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (512 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (660 aa)
psma6Proteasome subunit alpha type. (246 aa)
W5MSA1_LEPOCRegulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa)
DNA2DNA replication helicase/nuclease 2. (1397 aa)
psma2Proteasome subunit alpha type. (234 aa)
psma3Proteasome subunit alpha type. (255 aa)
W5MTM3_LEPOCCDC23 (cell division cycle 23, yeast, homolog). (569 aa)
orc2Origin recognition complex, subunit 2. (576 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
LOC102692087Fizzy/cell division cycle 20 related 1b. (486 aa)
rpa3Replication protein A3. (121 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC102682223PCI domain-containing protein. (380 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (404 aa)
LOC102683700Uncharacterized protein. (148 aa)
cdc26Cell division cycle 26 homolog. (88 aa)
W5LXB1_LEPOCUncharacterized protein. (53 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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