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| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (627 aa) |
| | LOC102686492 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | LOC102699233 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | W5NLL5_LEPOC | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | LOC102691582 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (225 aa) |
| | mcm9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (660 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (386 aa) |
| | W5NJX2_LEPOC | Origin recognition complex, subunit 3. (728 aa) |
| | ywhaq | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (260 aa) |
| | W5NIU6_LEPOC | Exonuclease 1. (797 aa) |
| | wee2 | Wee1-like protein kinase. (582 aa) |
| | rhno1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (290 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (852 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (475 aa) |
| | psme4 | Proteasome activator subunit 4b. (1848 aa) |
| | GTSE1 | G2 and S-phase expressed 1. (716 aa) |
| | psmc2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa) |
| | W5NG96_LEPOC | DNA helicase; Belongs to the MCM family. (815 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (867 aa) |
| | rps27a | Ribosomal protein S27a. (162 aa) |
| | psmb1 | Proteasome subunit beta. (237 aa) |
| | W5NEJ3_LEPOC | Origin recognition complex, subunit 5. (375 aa) |
| | W5NEB6_LEPOC | Reverse transcriptase domain-containing protein. (596 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (173 aa) |
| | W5ND91_LEPOC | Uncharacterized protein. (96 aa) |
| | psma4 | Proteasome subunit alpha type. (261 aa) |
| | W5NBP5_LEPOC | Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (388 aa) |
| | psmd10 | Proteasome 26S subunit, non-ATPase 10. (228 aa) |
| | ccnb3 | Cyclin B3; Belongs to the cyclin family. (419 aa) |
| | blm | BLM RecQ like helicase. (1481 aa) |
| | W5NA30_LEPOC | Proteasome 26S subunit, non-ATPase 8. (292 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1964 aa) |
| | W5NA15_LEPOC | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (250 aa) |
| | W5N933_LEPOC | Reverse transcriptase domain-containing protein. (704 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa) |
| | W5N8T9_LEPOC | ATR interacting protein. (763 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (262 aa) |
| | W5N8D2_LEPOC | Proteasome subunit beta 6. (225 aa) |
| | psmb3 | Proteasome subunit beta. (224 aa) |
| | W5N875_LEPOC | Cyclin B2; Belongs to the cyclin family. (394 aa) |
| | psmd12 | Proteasome 26S subunit, non-ATPase 12. (462 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (887 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (613 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | LOC102695737 | DNA helicase; Belongs to the MCM family. (834 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa) |
| | psmd11 | Proteasome 26S subunit, non-ATPase 11b. (426 aa) |
| | psmd3 | Proteasome 26S subunit, non-ATPase 3. (514 aa) |
| | psma5 | Proteasome subunit alpha type. (241 aa) |
| | W5N3D9_LEPOC | Uncharacterized protein. (465 aa) |
| | psme3 | Proteasome activator subunit 3. (258 aa) |
| | LOC102697986 | DNA helicase; Belongs to the MCM family. (814 aa) |
| | W5N2Q8_LEPOC | Abraxas 1, BRCA1 A complex subunit. (411 aa) |
| | psmc6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (404 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1514 aa) |
| | psmc5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | LOC102682223 | PCI domain-containing protein. (380 aa) |
| | W5N048_LEPOC | Uncharacterized protein. (1423 aa) |
| | rpa3 | Replication protein A3. (121 aa) |
| | W5MXW8_LEPOC | WRN RecQ like helicase. (1464 aa) |
| | ccnb1 | Cyclin B1; Belongs to the cyclin family. (398 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | W5MWB9_LEPOC | DBF4 zinc finger. (622 aa) |
| | psmd6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | W5MW35_LEPOC | Nibrin. (846 aa) |
| | orc2 | Origin recognition complex, subunit 2. (576 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (463 aa) |
| | LOC102686431 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa) |
| | psma3 | Proteasome subunit alpha type. (255 aa) |
| | psma2 | Proteasome subunit alpha type. (234 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1397 aa) |
| | W5MSA1_LEPOC | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa) |
| | psma6 | Proteasome subunit alpha type. (246 aa) |
| | W5MRH9_LEPOC | Proteasome 26S subunit, ATPase 1a; Belongs to the AAA ATPase family. (441 aa) |
| | LOC102685849 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | psmd14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | W5MNX2_LEPOC | Uncharacterized protein. (298 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (725 aa) |
| | ywhab | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a; Belongs to the 14-3-3 family. (246 aa) |
| | recql4 | RecQ helicase-like 4. (1459 aa) |
| | W5ML00_LEPOC | Cell division cycle associated 7a. (393 aa) |
| | psmf1 | Proteasome inhibitor subunit 1. (305 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (290 aa) |
| | ywhae | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (285 aa) |
| | W5MJK0_LEPOC | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1380 aa) |
| | cdk1 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa) |
| | psma8 | Proteasome subunit alpha type. (251 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa) |
| | W5MGR7_LEPOC | Piezo-type mechanosensitive ion channel component. (2690 aa) |
| | psmc3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (443 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (678 aa) |
| | W5MFP2_LEPOC | Protein inhibitor of activated STAT, 4a. (489 aa) |
| | wdr41 | WD repeat domain 41. (448 aa) |
| | orc6 | Origin recognition complex, subunit 6. (256 aa) |
| | W5MDS2_LEPOC | ANK_REP_REGION domain-containing protein. (1588 aa) |
| | psmd9 | Proteasome 26S subunit, non-ATPase 9. (215 aa) |
| | psmb7 | Proteasome subunit beta. (284 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (471 aa) |
| | psmc4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (803 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae). (545 aa) |
| | piezo1 | Piezo-type mechanosensitive ion channel component. (2541 aa) |
| | psmd1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (963 aa) |
| | tdrd3 | Tudor domain containing 3. (743 aa) |
| | W5M9K5_LEPOC | RAD17 checkpoint clamp loader component. (584 aa) |
| | rmi2 | RecQ mediated genome instability 2. (154 aa) |
| | CDK2 | Cyclin dependent kinase 2. (252 aa) |
| | psmd7 | Proteasome 26S subunit, non-ATPase 7. (326 aa) |
| | chek2 | Checkpoint kinase 2. (518 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | wee1 | Wee1-like protein kinase. (619 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (367 aa) |
| | psmd5 | Proteasome 26S subunit, non-ATPase 5. (522 aa) |
| | psma1 | Proteasome subunit alpha type. (268 aa) |
| | rpa2 | Replication protein A2. (277 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (347 aa) |
| | ywhag | 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa) |
| | W5M3S0_LEPOC | Ankyrin repeat domain 12. (2028 aa) |
| | psmd13 | Proteasome 26S subunit, non-ATPase 13. (408 aa) |
| | W5M2U2_LEPOC | Piezo-type mechanosensitive ion channel component. (2881 aa) |
| | W5M2L3_LEPOC | Ring finger protein 169. (462 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa) |
| | RBBP8 | Uncharacterized protein. (865 aa) |
| | W5M0D4_LEPOC | SMC5-SMC6 complex localization factor 1. (858 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | W5LZK6_LEPOC | Non-specific serine/threonine protein kinase. (3061 aa) |
| | CDC25B | Cell division cycle 25B. (574 aa) |
| | W5LYH4_LEPOC | Proteasome activator subunit 1. (161 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (358 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (359 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (819 aa) |
| | W5LXK8_LEPOC | Uncharacterized protein. (133 aa) |
| | psmb2 | Proteasome subunit beta. (200 aa) |
| | W5LXB1_LEPOC | Uncharacterized protein. (53 aa) |
| | CLSPN | Claspin. (1303 aa) |
| | W5LWT0_LEPOC | Reverse transcriptase domain-containing protein. (604 aa) |
| | W5LWH6_LEPOC | Reverse transcriptase domain-containing protein. (823 aa) |
| | W5LWC3_LEPOC | PINIT domain-containing protein. (82 aa) |
| | LOC102683700 | Uncharacterized protein. (148 aa) |
