(62 nodes) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S network (Lepisosteus oculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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Your Input:
	W5MIR9_LEPOC	Si:dkey-159f12.2. (110 aa)
	W5MI85_LEPOC	40S ribosomal protein S27. (102 aa)
	rps3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
	W5ME38_LEPOC	Eukaryotic translation initiation factor 4Ba. (615 aa)
	rps21	40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
	RPS20	Ribosomal protein S20. (119 aa)
	W5MCQ8_LEPOC	Eukaryotic translation initiation factor 4E binding protein 2. (125 aa)
	W5MC13_LEPOC	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (137 aa)
	eif3m	Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (375 aa)
	W5M9U4_LEPOC	Ribosomal protein S19. (83 aa)
	eif3b	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (682 aa)
	arl6ip1	ADP-ribosylation factor-like 6 interacting protein 1. (203 aa)
	eif2s2	Eukaryotic translation initiation factor 2, subunit 2 beta. (335 aa)
	eif3g	Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (300 aa)
	W5ML68_LEPOC	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (635 aa)
	W5MLZ1_LEPOC	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (162 aa)
	W5MMW6_LEPOC	Ribosomal protein S9. (200 aa)
	rps3a	40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (319 aa)
	rps2	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (279 aa)
	LOC102697157	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family. (216 aa)
	PABPC3	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (640 aa)
	EIF3A	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1264 aa)
	rps10	Ribosomal protein S10. (196 aa)
	rps14	Ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (163 aa)
	W5MZ39_LEPOC	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (274 aa)
	RPS29	Ribosomal protein S29. (55 aa)
	W5N049_LEPOC	Uncharacterized protein. (121 aa)
	eif4e1b	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
	rpsa	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family. (308 aa)
	eif4e	Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
	eif4ebp3	Eukaryotic translation initiation factor 4E binding protein 3, like. (91 aa)
	rps23	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
	eif3j	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (252 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha a. (316 aa)
	eif3k	Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (205 aa)
	rps4x	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (262 aa)
	eif4a1	Eukaryotic translation initiation factor 4A1B; Belongs to the DEAD box helicase family. (411 aa)
	W5NC84_LEPOC	40S ribosomal protein S27. (82 aa)
	rps17	Ribosomal protein S17. (135 aa)
	LOC102689159	Uncharacterized protein. (118 aa)
	eif3l	Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (588 aa)
	rps12	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (132 aa)
	rps16	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (154 aa)
	rps7	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
	LOC102696747	NAD(P)-bd_dom domain-containing protein. (132 aa)
	eif1ax	Eukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (152 aa)
	LOC102692574	40S ribosomal protein S27. (84 aa)
	eif2s3	Eukaryotic translation initiation factor 2, subunit 3 gamma. (472 aa)
	eif3h	Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (347 aa)
	W5M642_LEPOC	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (132 aa)
	eif3e	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
	W5M5B4_LEPOC	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (206 aa)
	rps13	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (151 aa)
	rps28	Ribosomal protein S28. (82 aa)
	EIF3I	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (323 aa)
	W5M2I5_LEPOC	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
	pabpc4	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (635 aa)
	eif3f	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (288 aa)
	eif4a2	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (411 aa)
	W5LXF3_LEPOC	Ribosomal_S7 domain-containing protein. (142 aa)
	W5LVC6_LEPOC	Uncharacterized protein. (138 aa)
	rps15a	Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family. (154 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF3A	EIF3I	ENSLOCP00000011886	ENSLOCP00000002853	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.999
EIF3A	LOC102692574	ENSLOCP00000011886	ENSLOCP00000004152	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S27.	0.952
EIF3A	LOC102696747	ENSLOCP00000011886	ENSLOCP00000004960	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	NAD(P)-bd_dom domain-containing protein.	0.704
EIF3A	LOC102697157	ENSLOCP00000011886	ENSLOCP00000011391	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	0.493
EIF3A	PABPC3	ENSLOCP00000011886	ENSLOCP00000011833	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.686
EIF3A	RPS20	ENSLOCP00000011886	ENSLOCP00000006538	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal protein S20.	0.990
EIF3A	RPS29	ENSLOCP00000011886	ENSLOCP00000013995	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal protein S29.	0.975
EIF3A	W5LVC6_LEPOC	ENSLOCP00000011886	ENSLOCP00000000083	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Uncharacterized protein.	0.991
EIF3A	W5LXF3_LEPOC	ENSLOCP00000011886	ENSLOCP00000000810	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal_S7 domain-containing protein.	0.976
EIF3A	W5M2I5_LEPOC	ENSLOCP00000011886	ENSLOCP00000002593	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.978
EIF3A	W5M5B4_LEPOC	ENSLOCP00000011886	ENSLOCP00000003572	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.982
EIF3A	W5M642_LEPOC	ENSLOCP00000011886	ENSLOCP00000003850	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.982
EIF3A	W5M9U4_LEPOC	ENSLOCP00000011886	ENSLOCP00000005153	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal protein S19.	0.977
EIF3A	W5MC13_LEPOC	ENSLOCP00000011886	ENSLOCP00000005922	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.980
EIF3A	W5ME38_LEPOC	ENSLOCP00000011886	ENSLOCP00000006647	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Eukaryotic translation initiation factor 4Ba.	0.909
EIF3A	W5MI85_LEPOC	ENSLOCP00000011886	ENSLOCP00000008094	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S27.	0.954
EIF3A	W5MIR9_LEPOC	ENSLOCP00000011886	ENSLOCP00000008278	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Si:dkey-159f12.2.	0.985
EIF3A	W5ML68_LEPOC	ENSLOCP00000011886	ENSLOCP00000009127	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.686
EIF3A	W5MLZ1_LEPOC	ENSLOCP00000011886	ENSLOCP00000009400	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.990
EIF3A	W5MMW6_LEPOC	ENSLOCP00000011886	ENSLOCP00000009725	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	Ribosomal protein S9.	0.978