47 items (Lepisosteus oculatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	W5MSA1_LEPOC	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (613 aa)
	LOC107076474-2	poly(ADP-ribose) glycohydrolase ARH3-like. (97 aa)
	W5LXJ3_LEPOC	DNA_pol_B domain-containing protein. (97 aa)
	W5LXM9_LEPOC	ADP-ribosylhydrolase like 2. (281 aa)
	rfc4	Replication factor C (activator 1) 4. (359 aa)
	rfc2	Replication factor C (activator 1) 2. (358 aa)
	W5M103_LEPOC	DNA ligase. (1030 aa)
	lig3	DNA ligase. (1001 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (473 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (510 aa)
	rpa2	Replication protein A2. (277 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (340 aa)
	rfc5	Replication factor C (activator 1) 5. (367 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (135 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
	W5M9S6_LEPOC	XPGI domain-containing protein. (345 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (302 aa)
	meiob	Methionine sulfoxide reductase B1b. (471 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (648 aa)
	parg	Poly (ADP-ribose) glycohydrolase a. (954 aa)
	W5MFH8_LEPOC	Von Willebrand factor A domain containing 5B2. (1207 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	W5MHC5_LEPOC	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (268 aa)
	W5MHX5_LEPOC	Polynucleotide kinase 3'-phosphatase. (601 aa)
	mpg	N-methylpurine DNA glycosylase. (279 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	LOC102685849	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
	parp3	Poly [ADP-ribose] polymerase. (516 aa)
	rpa3	Replication protein A3. (121 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	rfc1	Replication factor C subunit 1. (1204 aa)
	MBD4	MBD domain-containing protein. (497 aa)
	W5N8N6_LEPOC	ATPase family AAA domain containing 5a. (1812 aa)
	apex2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (569 aa)
	W5NB54_LEPOC	8-oxoguanine DNA glycosylase. (354 aa)
	W5NB97_LEPOC	REC114 meiotic recombination protein. (240 aa)
	W5NCJ0_LEPOC	Nei-like DNA glycosylase 1. (416 aa)
	tdg	Thymine DNA glycosylase, tandem duplicate 2. (247 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (469 aa)
	W5NDV2_LEPOC	Poly (ADP-ribose) glycohydrolase, like. (500 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
	polb	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1009 aa)
	W5LVZ4_LEPOC	Poly [ADP-ribose] polymerase. (480 aa)
	LOC107076474	Uncharacterized protein. (97 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107076474	parp3	ENSLOCP00000000386	ENSLOCP00000013066	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.444
LOC107076474-2	parp3	ENSLOCP00000000536	ENSLOCP00000013066	poly(ADP-ribose) glycohydrolase ARH3-like.	Poly [ADP-ribose] polymerase.	0.444
MBD4	W5M103_LEPOC	ENSLOCP00000016075	ENSLOCP00000002060	MBD domain-containing protein.	DNA ligase.	0.545
MBD4	W5MHC5_LEPOC	ENSLOCP00000016075	ENSLOCP00000007784	MBD domain-containing protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.558
MBD4	apex1	ENSLOCP00000016075	ENSLOCP00000019094	MBD domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.646
MBD4	apex2	ENSLOCP00000016075	ENSLOCP00000017811	MBD domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.529
MBD4	polb	ENSLOCP00000016075	ENSLOCP00000019231	MBD domain-containing protein.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.471
MBD4	tdg	ENSLOCP00000016075	ENSLOCP00000018495	MBD domain-containing protein.	Thymine DNA glycosylase, tandem duplicate 2.	0.555
MUTYH	NTHL1	ENSLOCP00000003402	ENSLOCP00000003638	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.953
MUTYH	W5LXJ3_LEPOC	ENSLOCP00000003402	ENSLOCP00000000850	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	DNA_pol_B domain-containing protein.	0.593
MUTYH	W5M103_LEPOC	ENSLOCP00000003402	ENSLOCP00000002060	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	DNA ligase.	0.434
MUTYH	W5M9S6_LEPOC	ENSLOCP00000003402	ENSLOCP00000005135	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	XPGI domain-containing protein.	0.581
MUTYH	W5MHX5_LEPOC	ENSLOCP00000003402	ENSLOCP00000007984	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Polynucleotide kinase 3'-phosphatase.	0.412
MUTYH	W5NB54_LEPOC	ENSLOCP00000003402	ENSLOCP00000017863	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	8-oxoguanine DNA glycosylase.	0.614
MUTYH	W5NCJ0_LEPOC	ENSLOCP00000003402	ENSLOCP00000018349	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Nei-like DNA glycosylase 1.	0.417
MUTYH	apex1	ENSLOCP00000003402	ENSLOCP00000019094	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.869
MUTYH	apex2	ENSLOCP00000003402	ENSLOCP00000017811	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.859
MUTYH	mpg	ENSLOCP00000003402	ENSLOCP00000009349	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	N-methylpurine DNA glycosylase.	0.448
MUTYH	pcna	ENSLOCP00000003402	ENSLOCP00000019251	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.846
MUTYH	polb	ENSLOCP00000003402	ENSLOCP00000019231	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.454