(48 nodes) Ligand binding domain of hormone receptors network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5MCT0_LEPOC	Nuclear receptor subfamily 6, group A, member 1a. (457 aa)
	LOC102684941	Retinoid X receptor, gamma b. (466 aa)
	nr2f1	Nuclear receptor subfamily 2, group F, member 1a. (416 aa)
	W5M1L6_LEPOC	Hepatocyte nuclear factor 4, alpha. (465 aa)
	nr2f6	Nuclear receptor subfamily 2, group F, member 6a. (403 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2b. (266 aa)
	LOC102690640	Uncharacterized protein. (463 aa)
	LOC102695553	Nuclear receptor subfamily 1, group I, member 2. (318 aa)
	W5MAH5_LEPOC	Nuclear receptor subfamily 4, group A, member 1. (608 aa)
	RXRA	Retinoid X receptor, alpha a. (513 aa)
	nr5a1	Nuclear receptor subfamily 5, group A, member 1a. (481 aa)
	vdr	Vitamin D receptor a. (433 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (682 aa)
	pgr	Progesterone receptor. (704 aa)
	NR4A2	Nuclear receptor subfamily 4, group A, member 2b. (595 aa)
	rarg	Retinoic acid receptor gamma a. (494 aa)
	W5MH03_LEPOC	Nuclear receptor subfamily 1, group H, member 3. (280 aa)
	LOC102695885	RAR-related orphan receptor C a. (467 aa)
	nr1d2	Nuclear receptor subfamily 1, group D, member 2a. (604 aa)
	thrb	Thyroid hormone receptor beta. (475 aa)
	RARB	Retinoic acid receptor beta. (444 aa)
	LOC102698622	Nuclear receptor subfamily 5, group A, member 5. (492 aa)
	nr5a2	Nuclear receptor subfamily 5, group A, member 2. (539 aa)
	nr3c2	Nuclear receptor subfamily 3, group C, member 2. (987 aa)
	LOC102699181	Nuclear receptor subfamily 2, group F, member 5. (404 aa)
	LOC102683760	Nuclear receptor subfamily 0, group B, member 1. (261 aa)
	rorb	RAR-related orphan receptor B. (462 aa)
	esr2	Estrogen receptor 2a. (571 aa)
	LOC102686811	Uncharacterized protein. (512 aa)
	nr3c1	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (786 aa)
	esrrb	Estrogen-related receptor beta. (463 aa)
	LOC102683376	Nuclear receptor subfamily 2, group C, member 2. (628 aa)
	LOC102683645	Peroxisome proliferator-activated receptor delta b. (438 aa)
	rara	Retinoic acid receptor, alpha a. (469 aa)
	LOC102682597	Thyroid hormone receptor alpha a. (410 aa)
	hnf4g	Hepatocyte nuclear factor 4, gamma. (464 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (484 aa)
	nr2f2	Nuclear receptor subfamily 2, group F, member 2. (423 aa)
	LOC102698328	Estrogen-related receptor delta. (464 aa)
	ar	Androgen receptor. (859 aa)
	rora	RAR-related orphan receptor A, paralog a. (519 aa)
	nr2e3	Nuclear receptor subfamily 2, group E, member 3. (416 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	nr2c1	Nuclear receptor subfamily 2, group C, member 1. (612 aa)
	esrrg	Estrogen-related receptor gamma a. (466 aa)
	esr1	Estrogen receptor 1. (995 aa)
	nr2e1	Nuclear receptor subfamily 2, group E, member 1. (398 aa)
	W5NK92_LEPOC	Peroxisome proliferator-activated receptor alpha a. (397 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102682597	LOC102684941	ENSLOCP00000016031	ENSLOCP00000001534	Thyroid hormone receptor alpha a.	Retinoid X receptor, gamma b.	0.925
LOC102682597	LOC102686811	ENSLOCP00000016031	ENSLOCP00000012738	Thyroid hormone receptor alpha a.	Uncharacterized protein.	0.478
LOC102682597	LOC102698622	ENSLOCP00000016031	ENSLOCP00000008520	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 5, group A, member 5.	0.421
LOC102682597	NR4A2	ENSLOCP00000016031	ENSLOCP00000006932	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 4, group A, member 2b.	0.415
LOC102682597	RXRA	ENSLOCP00000016031	ENSLOCP00000005489	Thyroid hormone receptor alpha a.	Retinoid X receptor, alpha a.	0.925
LOC102682597	W5MAH5_LEPOC	ENSLOCP00000016031	ENSLOCP00000005384	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 4, group A, member 1.	0.415
LOC102682597	W5MH03_LEPOC	ENSLOCP00000016031	ENSLOCP00000007662	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 1, group H, member 3.	0.444
LOC102682597	nr1d2	ENSLOCP00000016031	ENSLOCP00000008260	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 1, group D, member 2a.	0.863
LOC102682597	nr1h4	ENSLOCP00000016031	ENSLOCP00000018713	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 1, group H, member 4.	0.478
LOC102682597	nr4a3	ENSLOCP00000016031	ENSLOCP00000006467	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 4, group A, member 3.	0.415
LOC102682597	nr5a1	ENSLOCP00000016031	ENSLOCP00000006214	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 5, group A, member 1a.	0.421
LOC102682597	nr5a2	ENSLOCP00000016031	ENSLOCP00000009307	Thyroid hormone receptor alpha a.	Nuclear receptor subfamily 5, group A, member 2.	0.421
LOC102682597	thrb	ENSLOCP00000016031	ENSLOCP00000008294	Thyroid hormone receptor alpha a.	Thyroid hormone receptor beta.	0.857
LOC102683376	LOC102698622	ENSLOCP00000013713	ENSLOCP00000008520	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 5, group A, member 5.	0.421
LOC102683376	NR4A2	ENSLOCP00000013713	ENSLOCP00000006932	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 4, group A, member 2b.	0.456
LOC102683376	W5MAH5_LEPOC	ENSLOCP00000013713	ENSLOCP00000005384	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 4, group A, member 1.	0.456
LOC102683376	nr4a3	ENSLOCP00000013713	ENSLOCP00000006467	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 4, group A, member 3.	0.519
LOC102683376	nr5a1	ENSLOCP00000013713	ENSLOCP00000006214	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 5, group A, member 1a.	0.455
LOC102683376	nr5a2	ENSLOCP00000013713	ENSLOCP00000009307	Nuclear receptor subfamily 2, group C, member 2.	Nuclear receptor subfamily 5, group A, member 2.	0.455
LOC102683645	LOC102684941	ENSLOCP00000014290	ENSLOCP00000001534	Peroxisome proliferator-activated receptor delta b.	Retinoid X receptor, gamma b.	0.924