(65 nodes) Alanine, aspartate and glutamate metabolism network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	acy3	Uncharacterized protein. (144 aa)
	glud1	Glutamate dehydrogenase 1a; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (543 aa)
	INF2	Inverted formin, FH2 and WH2 domain containing. (1279 aa)
	adss1	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	LOC102687494	Zgc:163121. (552 aa)
	W5N5L7_LEPOC	Glutaminase like. (646 aa)
	W5N9F8_LEPOC	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (511 aa)
	gpkow	G patch domain and KOW motifs. (545 aa)
	LOC102689506	Glutamic-oxaloacetic transaminase 1 like 1. (413 aa)
	W5NCS1_LEPOC	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). (188 aa)
	LOC102690721	Glutamine--fructose-6-phosphate transaminase 1. (689 aa)
	W5NE90_LEPOC	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (459 aa)
	LOC102690649	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (380 aa)
	cad	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2259 aa)
	tasp1	Taspase, threonine aspartase, 1. (429 aa)
	asrgl1	Asparaginase like 1. (310 aa)
	W5NJD2_LEPOC	G_PROTEIN_RECEP_F1_2 domain-containing protein. (374 aa)
	LOC102688735	Si:dkey-103j14.5. (328 aa)
	W5NK79_LEPOC	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (690 aa)
	slc22a16	Solute carrier family 22 member 16. (577 aa)
	W5MSW7_LEPOC	Uncharacterized protein. (750 aa)
	gls	Glutaminase a. (636 aa)
	LOC102688369	Glutamine-fructose-6-phosphate transaminase 2. (703 aa)
	gpr143	G protein-coupled receptor 143. (424 aa)
	nit2	Nitrilase family, member 2. (285 aa)
	asns	Asparagine synthetase [glutamine-hydrolyzing]. (562 aa)
	W5MZ58_LEPOC	Si:ch211-256m1.8. (1568 aa)
	W5N065_LEPOC	Lyase_1 domain-containing protein. (114 aa)
	W5N1L2_LEPOC	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
	LOC102696231	Amine oxidase. (531 aa)
	W5NMT8_LEPOC	HIT domain-containing protein. (298 aa)
	gad1	Glutamate decarboxylase 1a. (592 aa)
	W5MMS2_LEPOC	Si:ch211-157p22.10. (362 aa)
	asnsd1	Asparagine synthetase domain containing 1. (617 aa)
	LOC102697165	Si:ch211-217a12.1. (489 aa)
	W5MRF7_LEPOC	Aminotran_1_2 domain-containing protein. (492 aa)
	got1	Aspartate aminotransferase. (413 aa)
	W5LWZ0_LEPOC	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (396 aa)
	W5LXV5_LEPOC	Amine oxidase. (513 aa)
	NAALADL2	N-acetylated alpha-linked acidic dipeptidase like 2. (817 aa)
	W5LZC8_LEPOC	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (351 aa)
	rimkla	Ribosomal modification protein rimK-like family member A. (394 aa)
	LOC107079957	Si:ch211-209a2.2. (269 aa)
	W5M2G2_LEPOC	Uncharacterized protein. (130 aa)
	nat8l	N-acetyltransferase 8-like. (295 aa)
	W5M392_LEPOC	Asparaginase domain-containing protein. (268 aa)
	W5M3B1_LEPOC	Uncharacterized protein. (344 aa)
	LOC102698727	Amine oxidase. (522 aa)
	abr-2	Aspartoacylase. (322 aa)
	NAALADL1	Si:ch211-214j8.1. (739 aa)
	glul	Glutamine synthetase. (376 aa)
	cps1	Carbamoyl-phosphate synthase 1, mitochondrial. (1511 aa)
	aldh4a1	IF rod domain-containing protein; Belongs to the aldehyde dehydrogenase family. (1495 aa)
	gls2	Glutaminase 2b (liver, mitochondrial). (609 aa)
	asl	Argininosuccinate lyase. (467 aa)
	ASS1	Argininosuccinate synthase 1. (414 aa)
	gpt2	Glutamic pyruvate transaminase (alanine aminotransferase) 2. (555 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa)
	W5MFW5_LEPOC	Amine oxidase. (507 aa)
	atad1	ATPase family AAA domain containing 1b; Belongs to the AAA ATPase family. (366 aa)
	got2	Aspartate aminotransferase. (446 aa)
	agxt	Serine--pyruvate aminotransferase. (428 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	folh1b	N-acetylated alpha-linked acidic dipeptidase 2. (738 aa)
	gad2	Glutamate decarboxylase 2. (581 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASS1	LOC102687494	ENSLOCP00000006487	ENSLOCP00000015844	Argininosuccinate synthase 1.	Zgc:163121.	0.870
ASS1	LOC102688369	ENSLOCP00000006487	ENSLOCP00000012335	Argininosuccinate synthase 1.	Glutamine-fructose-6-phosphate transaminase 2.	0.862
ASS1	LOC102689506	ENSLOCP00000006487	ENSLOCP00000018416	Argininosuccinate synthase 1.	Glutamic-oxaloacetic transaminase 1 like 1.	0.867
ASS1	LOC102690721	ENSLOCP00000006487	ENSLOCP00000018434	Argininosuccinate synthase 1.	Glutamine--fructose-6-phosphate transaminase 1.	0.862
ASS1	LOC102696231	ENSLOCP00000006487	ENSLOCP00000021261	Argininosuccinate synthase 1.	Amine oxidase.	0.694
ASS1	LOC102697165	ENSLOCP00000006487	ENSLOCP00000010938	Argininosuccinate synthase 1.	Si:ch211-217a12.1.	0.691
ASS1	LOC102698727	ENSLOCP00000006487	ENSLOCP00000003374	Argininosuccinate synthase 1.	Amine oxidase.	0.694
ASS1	LOC107079957	ENSLOCP00000006487	ENSLOCP00000002288	Argininosuccinate synthase 1.	Si:ch211-209a2.2.	0.753
ASS1	W5LWZ0_LEPOC	ENSLOCP00000006487	ENSLOCP00000000647	Argininosuccinate synthase 1.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.916
ASS1	W5LXV5_LEPOC	ENSLOCP00000006487	ENSLOCP00000000962	Argininosuccinate synthase 1.	Amine oxidase.	0.694
ASS1	W5LZC8_LEPOC	ENSLOCP00000006487	ENSLOCP00000001485	Argininosuccinate synthase 1.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.916
ASS1	W5M392_LEPOC	ENSLOCP00000006487	ENSLOCP00000002850	Argininosuccinate synthase 1.	Asparaginase domain-containing protein.	0.753
ASS1	W5M3B1_LEPOC	ENSLOCP00000006487	ENSLOCP00000002869	Argininosuccinate synthase 1.	Uncharacterized protein.	0.753
ASS1	W5MFW5_LEPOC	ENSLOCP00000006487	ENSLOCP00000007274	Argininosuccinate synthase 1.	Amine oxidase.	0.859
ASS1	W5MMS2_LEPOC	ENSLOCP00000006487	ENSLOCP00000009681	Argininosuccinate synthase 1.	Si:ch211-157p22.10.	0.944
ASS1	W5MRF7_LEPOC	ENSLOCP00000006487	ENSLOCP00000010966	Argininosuccinate synthase 1.	Aminotran_1_2 domain-containing protein.	0.691
ASS1	W5N065_LEPOC	ENSLOCP00000006487	ENSLOCP00000014024	Argininosuccinate synthase 1.	Lyase_1 domain-containing protein.	0.724
ASS1	W5N9F8_LEPOC	ENSLOCP00000006487	ENSLOCP00000017267	Argininosuccinate synthase 1.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.946
ASS1	W5NE90_LEPOC	ENSLOCP00000006487	ENSLOCP00000018949	Argininosuccinate synthase 1.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.916
ASS1	W5NJD2_LEPOC	ENSLOCP00000006487	ENSLOCP00000020741	Argininosuccinate synthase 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.944