(53 nodes) Tyrosine metabolism network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	LOC102682479	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (439 aa)
	W5LXH2_LEPOC	Aldedh domain-containing protein. (89 aa)
	W5LXV5_LEPOC	Amine oxidase. (513 aa)
	th	Tyrosine hydroxylase. (492 aa)
	hgd	Homogentisate 1,2-dioxygenase. (443 aa)
	W5M1R1_LEPOC	Amine oxidase. (525 aa)
	dbh	Dopamine beta-hydroxylase (dopamine beta-monooxygenase). (615 aa)
	tat	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
	LOC102698727	Amine oxidase. (522 aa)
	W5M5D0_LEPOC	4-hydroxyphenylpyruvate dioxygenase; Belongs to the 4HPPD family. (399 aa)
	W5M8K8_LEPOC	Zgc:85789. (319 aa)
	comtd1	Catechol-O-methyltransferase domain containing 1. (264 aa)
	adhfe1	Alcohol dehydrogenase iron containing 1. (471 aa)
	dct	Dopachrome tautomerase. (520 aa)
	W5MCL4_LEPOC	Fumarylacetoacetate hydrolase domain containing 1. (224 aa)
	hpd	4-hydroxyphenylpyruvate dioxygenase. (417 aa)
	W5MFW5_LEPOC	Amine oxidase. (507 aa)
	got2	Aspartate aminotransferase. (446 aa)
	LOC102695813	D-dopachrome tautomerase. (118 aa)
	mif	Macrophage migration inhibitory factor. (117 aa)
	W5MJD1_LEPOC	Uncharacterized protein. (155 aa)
	tyr	Tyrosinase. (540 aa)
	LOC102691070	Transmembrane O-methyltransferase. (268 aa)
	hpdl	4-hydroxyphenylpyruvate dioxygenase-like. (494 aa)
	them6	Thioesterase superfamily member 6. (206 aa)
	got1	Aspartate aminotransferase. (413 aa)
	leng9	C3H1-type domain-containing protein. (303 aa)
	gstz1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (220 aa)
	LOC102691008	Uncharacterized protein. (253 aa)
	LOC102696963	Alcohol dehydrogenase 8b. (855 aa)
	W5N2Y0_LEPOC	Amine oxidase. (770 aa)
	LOC102685513	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (378 aa)
	LOC102695719	PKS_ER domain-containing protein. (372 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (539 aa)
	PNMT	Phenylethanolamine N-methyltransferase. (286 aa)
	fah	Fumarylacetoacetase. (447 aa)
	tyrp1	Tyrosinase-related protein 1a. (536 aa)
	MAOA	Amine oxidase. (531 aa)
	ammecr1	AMMECR1 domain-containing protein. (355 aa)
	comt	Catechol-O-methyltransferase b. (272 aa)
	LOC102689506	Glutamic-oxaloacetic transaminase 1 like 1. (413 aa)
	FAHD2B	Fumarylacetoacetate hydrolase domain containing 2B. (309 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (598 aa)
	LOC102691383	Amine oxidase. (536 aa)
	TPO	Thyroid peroxidase. (735 aa)
	LOC102684830	Monooxygenase, DBH-like 1, like. (531 aa)
	W5NK82_LEPOC	Monooxygenase, DBH-like 1. (651 aa)
	LOC102696231	Amine oxidase. (531 aa)
	W5NMS6_LEPOC	Fidgetin; Belongs to the AAA ATPase family. (753 aa)
	W5NNV0_LEPOC	Si:dkey-157g16.6. (142 aa)
	fignl1	Fidgetin-like 1; Belongs to the AAA ATPase family. (682 aa)
	rbm12b	RNA binding motif protein 12B. (662 aa)
	rbm12	RNA binding motif protein 12. (893 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAHD2B	LOC102682479	ENSLOCP00000019255	ENSLOCP00000000446	Fumarylacetoacetate hydrolase domain containing 2B.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.687
FAHD2B	W5LXH2_LEPOC	ENSLOCP00000019255	ENSLOCP00000000829	Fumarylacetoacetate hydrolase domain containing 2B.	Aldedh domain-containing protein.	0.687
FAHD2B	W5M5D0_LEPOC	ENSLOCP00000019255	ENSLOCP00000003588	Fumarylacetoacetate hydrolase domain containing 2B.	4-hydroxyphenylpyruvate dioxygenase; Belongs to the 4HPPD family.	0.439
FAHD2B	fah	ENSLOCP00000019255	ENSLOCP00000015723	Fumarylacetoacetate hydrolase domain containing 2B.	Fumarylacetoacetase.	0.873
FAHD2B	gstz1	ENSLOCP00000019255	ENSLOCP00000013217	Fumarylacetoacetate hydrolase domain containing 2B.	Glutathione S-transferase zeta 1; Belongs to the GST superfamily.	0.601
FAHD2B	hgd	ENSLOCP00000019255	ENSLOCP00000002239	Fumarylacetoacetate hydrolase domain containing 2B.	Homogentisate 1,2-dioxygenase.	0.908
FAHD2B	hpd	ENSLOCP00000019255	ENSLOCP00000006299	Fumarylacetoacetate hydrolase domain containing 2B.	4-hydroxyphenylpyruvate dioxygenase.	0.439
FAHD2B	hpdl	ENSLOCP00000019255	ENSLOCP00000009719	Fumarylacetoacetate hydrolase domain containing 2B.	4-hydroxyphenylpyruvate dioxygenase-like.	0.439
KATNAL2	LOC102689506	ENSLOCP00000015252	ENSLOCP00000018416	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Glutamic-oxaloacetic transaminase 1 like 1.	0.458
KATNAL2	LOC102691070	ENSLOCP00000015252	ENSLOCP00000009472	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Transmembrane O-methyltransferase.	0.533
KATNAL2	LOC102696231	ENSLOCP00000015252	ENSLOCP00000021261	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Amine oxidase.	0.536
KATNAL2	LOC102698727	ENSLOCP00000015252	ENSLOCP00000003374	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Amine oxidase.	0.536
KATNAL2	SPAST	ENSLOCP00000015252	ENSLOCP00000019632	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]	0.504
KATNAL2	W5LXV5_LEPOC	ENSLOCP00000015252	ENSLOCP00000000962	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Amine oxidase.	0.536
KATNAL2	W5MFW5_LEPOC	ENSLOCP00000015252	ENSLOCP00000007274	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Amine oxidase.	0.536
KATNAL2	W5NMS6_LEPOC	ENSLOCP00000015252	ENSLOCP00000021935	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Fidgetin; Belongs to the AAA ATPase family.	0.461
KATNAL2	W5NNV0_LEPOC	ENSLOCP00000015252	ENSLOCP00000022309	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Si:dkey-157g16.6.	0.461
KATNAL2	comt	ENSLOCP00000015252	ENSLOCP00000017916	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Catechol-O-methyltransferase b.	0.533
KATNAL2	fignl1	ENSLOCP00000015252	ENSLOCP00000022429	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Fidgetin-like 1; Belongs to the AAA ATPase family.	0.495
KATNAL2	got1	ENSLOCP00000015252	ENSLOCP00000011040	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Aspartate aminotransferase.	0.458