(64 nodes) Pyruvate metabolism network (Lepisosteus oculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	W5MMM6_LEPOC	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family. (532 aa)
	W5M6Y6_LEPOC	CLPTM1 like. (536 aa)
	pdha1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa)
	LACTB2	Lactamase beta 2. (288 aa)
	W5M9Q8_LEPOC	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (939 aa)
	acacb	Acetyl-CoA carboxylase beta. (2385 aa)
	uevld	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (336 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2356 aa)
	hagh	Hydroxyacylglutathione hydrolase. (306 aa)
	HAGHL	Hydroxyacylglutathione hydrolase like. (277 aa)
	ACOT12	Acyl-CoA thioesterase 12. (568 aa)
	W5MDJ9_LEPOC	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (524 aa)
	acss2	Acyl-CoA synthetase short chain family member 2. (701 aa)
	aldh9a1	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (524 aa)
	W5MG55_LEPOC	Glyoxalase domain containing 4. (295 aa)
	kifc3	Kinesin family member C3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1017 aa)
	TSR1	TSR1 ribosome maturation factor. (743 aa)
	W5MHY8_LEPOC	Pyruvate kinase; Belongs to the pyruvate kinase family. (452 aa)
	parp8	Poly [ADP-ribose] polymerase. (849 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (623 aa)
	LOC107076226	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (86 aa)
	ACAD10	Acyl-CoA dehydrogenase family member 10. (998 aa)
	LOC102699097	Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (355 aa)
	aldh7a1	Aldehyde dehydrogenase 7 family, member A1; Belongs to the aldehyde dehydrogenase family. (540 aa)
	me3	Malic enzyme. (619 aa)
	mdh1b	Malate dehydrogenase 1B, NAD (soluble). (468 aa)
	W5MX10_LEPOC	Malate synthase-like. (550 aa)
	LOC102690807	Acetyl-coenzyme A synthetase. (686 aa)
	tmem104	Transmembrane protein 104. (492 aa)
	RNF138	Ring finger protein 138. (239 aa)
	LOC102689111	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (353 aa)
	LOC102694674	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
	me2	Malic enzyme. (583 aa)
	pdhb	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (360 aa)
	LOC102698680	Cocaine- and amphetamine-regulated transcript 3. (112 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa)
	LOC102683593	Zgc:113208. (162 aa)
	clptm1	CLPTM1 regulator of GABA type A receptor forward trafficking. (620 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (647 aa)
	pkm	Pyruvate kinase; Belongs to the pyruvate kinase family. (554 aa)
	parp6	Poly [ADP-ribose] polymerase. (650 aa)
	ldhb	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (335 aa)
	slc25a3	Solute carrier family 25 member 3b; Belongs to the mitochondrial carrier (TC 2.A.29) family. (358 aa)
	urb2	URB2 ribosome biogenesis homolog. (1533 aa)
	acyp2	Acylphosphatase. (73 aa)
	W5NFL9_LEPOC	Kinesin family member 25; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (554 aa)
	dld	Dihydrolipoyl dehydrogenase. (533 aa)
	W5NG53_LEPOC	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (351 aa)
	mdh1	Malate dehydrogenase. (350 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	fh	Fumarate hydratase. (506 aa)
	acss1	Acetyl-coenzyme A synthetase. (697 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (174 aa)
	me1	Malic enzyme. (588 aa)
	mdh2	Malate dehydrogenase. (337 aa)
	mblac2	Metallo-beta-lactamase domain containing 2. (275 aa)
	W5M1K4_LEPOC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
	W5M3R4_LEPOC	Bardet-Biedl syndrome 1. (507 aa)
	W5M400_LEPOC	Acyl-CoA synthetase short chain family member 2 like. (661 aa)
	acot11	Acyl-CoA thioesterase 11a. (576 aa)
	ldhd	Lactate dehydrogenase D. (497 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (637 aa)
	pnkd	PNKD metallo-beta-lactamase domain containing. (360 aa)
	LOC102697781	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAD10	LOC102690807	ENSLOCP00000009665	ENSLOCP00000013394	Acyl-CoA dehydrogenase family member 10.	Acetyl-coenzyme A synthetase.	0.563
ACAD10	LOC102698680	ENSLOCP00000009665	ENSLOCP00000017465	Acyl-CoA dehydrogenase family member 10.	Cocaine- and amphetamine-regulated transcript 3.	0.762
ACAD10	W5M400_LEPOC	ENSLOCP00000009665	ENSLOCP00000003108	Acyl-CoA dehydrogenase family member 10.	Acyl-CoA synthetase short chain family member 2 like.	0.563
ACAD10	W5MDJ9_LEPOC	ENSLOCP00000009665	ENSLOCP00000006458	Acyl-CoA dehydrogenase family member 10.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.473
ACAD10	acat2	ENSLOCP00000009665	ENSLOCP00000019962	Acyl-CoA dehydrogenase family member 10.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.762
ACAD10	acss1	ENSLOCP00000009665	ENSLOCP00000020759	Acyl-CoA dehydrogenase family member 10.	Acetyl-coenzyme A synthetase.	0.563
ACAD10	acss2	ENSLOCP00000009665	ENSLOCP00000006738	Acyl-CoA dehydrogenase family member 10.	Acyl-CoA synthetase short chain family member 2.	0.563
ACAD10	acyp2	ENSLOCP00000009665	ENSLOCP00000019105	Acyl-CoA dehydrogenase family member 10.	Acylphosphatase.	0.731
ACAD10	dlat	ENSLOCP00000009665	ENSLOCP00000001728	Acyl-CoA dehydrogenase family member 10.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.511
ACAD10	pdha1	ENSLOCP00000009665	ENSLOCP00000004156	Acyl-CoA dehydrogenase family member 10.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.508
ACOT12	LOC102690807	ENSLOCP00000006455	ENSLOCP00000013394	Acyl-CoA thioesterase 12.	Acetyl-coenzyme A synthetase.	0.695
ACOT12	LOC102698680	ENSLOCP00000006455	ENSLOCP00000017465	Acyl-CoA thioesterase 12.	Cocaine- and amphetamine-regulated transcript 3.	0.687
ACOT12	W5M400_LEPOC	ENSLOCP00000006455	ENSLOCP00000003108	Acyl-CoA thioesterase 12.	Acyl-CoA synthetase short chain family member 2 like.	0.690
ACOT12	W5MDJ9_LEPOC	ENSLOCP00000006455	ENSLOCP00000006458	Acyl-CoA thioesterase 12.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.728
ACOT12	W5MMM6_LEPOC	ENSLOCP00000006455	ENSLOCP00000009635	Acyl-CoA thioesterase 12.	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family.	0.794
ACOT12	W5MX10_LEPOC	ENSLOCP00000006455	ENSLOCP00000012919	Acyl-CoA thioesterase 12.	Malate synthase-like.	0.452
ACOT12	acaca	ENSLOCP00000006455	ENSLOCP00000006045	Acyl-CoA thioesterase 12.	Acetyl-CoA carboxylase alpha.	0.822
ACOT12	acacb	ENSLOCP00000006455	ENSLOCP00000005340	Acyl-CoA thioesterase 12.	Acetyl-CoA carboxylase beta.	0.822
ACOT12	acat2	ENSLOCP00000006455	ENSLOCP00000019962	Acyl-CoA thioesterase 12.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.841
ACOT12	acss1	ENSLOCP00000006455	ENSLOCP00000020759	Acyl-CoA thioesterase 12.	Acetyl-coenzyme A synthetase.	0.695