(34 nodes) Metabolism of xenobiotics by cytochrome P450 network (Lepisosteus oculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5MX30_LEPOC	UDP glucuronosyltransferase 1 family, polypeptide B5; Belongs to the UDP-glycosyltransferase family. (545 aa)
	mgst2	Microsomal glutathione S-transferase 2. (146 aa)
	W5MTS1_LEPOC	Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family. (519 aa)
	LOC102696798	Uncharacterized protein; Belongs to the GST superfamily. (243 aa)
	LOC102696601	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	LOC102683960	Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
	W5MDV8_LEPOC	Hydroxysteroid (11-beta) dehydrogenase 1-like b. (148 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (201 aa)
	LOC102683354	Aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase). (333 aa)
	LOC102683966	Glutathione S-transferase theta 2; Belongs to the GST superfamily. (277 aa)
	LOC102682479	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (439 aa)
	W5LXH2_LEPOC	Aldedh domain-containing protein. (89 aa)
	LOC102684327	Microsomal glutathione S-transferase 3b. (140 aa)
	W5M5G5_LEPOC	UDP glucuronosyltransferase 2 family, polypeptide A4; Belongs to the UDP-glycosyltransferase family. (541 aa)
	LOC102690887	Glutathione S-transferase rho; Belongs to the GST superfamily. (230 aa)
	clg12h2orf69	Zgc:153521. (365 aa)
	LOC102687541	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (525 aa)
	dhdh	Dihydrodiol dehydrogenase (dimeric), like. (379 aa)
	W5NFD7_LEPOC	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (476 aa)
	ephx1	Epoxide hydrolase 1, microsomal (xenobiotic). (558 aa)
	mgst1	Microsomal glutathione S-transferase 1.1. (157 aa)
	LOC102695612	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (534 aa)
	W5NJQ2_LEPOC	Uncharacterized protein. (62 aa)
	W5NMF6_LEPOC	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	W5NN46_LEPOC	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
	W5NN56_LEPOC	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
	W5NNJ4_LEPOC	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (534 aa)
	LOC102695719	PKS_ER domain-containing protein. (372 aa)
	LOC102685513	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (378 aa)
	LOC102694931	Uncharacterized protein; Belongs to the GST superfamily. (208 aa)
	W5N2T0_LEPOC	Glutathione S-transferase pi 1. (208 aa)
	gsto1	Glutathione S-transferase omega 2. (240 aa)
	LOC102696963	Alcohol dehydrogenase 8b. (855 aa)
	mgst3	Microsomal glutathione S-transferase 3a. (161 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HPGDS	LOC102682479	ENSLOCP00000015904	ENSLOCP00000000446	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.721
HPGDS	LOC102683966	ENSLOCP00000015904	ENSLOCP00000004532	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Glutathione S-transferase theta 2; Belongs to the GST superfamily.	0.817
HPGDS	LOC102684327	ENSLOCP00000015904	ENSLOCP00000003188	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Microsomal glutathione S-transferase 3b.	0.867
HPGDS	LOC102685513	ENSLOCP00000015904	ENSLOCP00000015035	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.	0.721
HPGDS	LOC102687541	ENSLOCP00000015904	ENSLOCP00000018011	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.876
HPGDS	LOC102690887	ENSLOCP00000015904	ENSLOCP00000004280	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Glutathione S-transferase rho; Belongs to the GST superfamily.	0.896
HPGDS	LOC102694931	ENSLOCP00000015904	ENSLOCP00000014947	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.825
HPGDS	LOC102695612	ENSLOCP00000015904	ENSLOCP00000020460	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.847
HPGDS	LOC102695719	ENSLOCP00000015904	ENSLOCP00000015044	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	PKS_ER domain-containing protein.	0.721
HPGDS	LOC102696601	ENSLOCP00000015904	ENSLOCP00000008313	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.817
HPGDS	LOC102696798	ENSLOCP00000015904	ENSLOCP00000008332	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Uncharacterized protein; Belongs to the GST superfamily.	0.817
HPGDS	LOC102696963	ENSLOCP00000015904	ENSLOCP00000014537	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Alcohol dehydrogenase 8b.	0.721
HPGDS	W5LXH2_LEPOC	ENSLOCP00000015904	ENSLOCP00000000829	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Aldedh domain-containing protein.	0.721
HPGDS	W5MTS1_LEPOC	ENSLOCP00000015904	ENSLOCP00000011780	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family.	0.823
HPGDS	W5N2T0_LEPOC	ENSLOCP00000015904	ENSLOCP00000014939	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Glutathione S-transferase pi 1.	0.825
HPGDS	W5NFD7_LEPOC	ENSLOCP00000015904	ENSLOCP00000019346	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.822
HPGDS	W5NJQ2_LEPOC	ENSLOCP00000015904	ENSLOCP00000020861	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Uncharacterized protein.	0.889
HPGDS	W5NMF6_LEPOC	ENSLOCP00000015904	ENSLOCP00000021815	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family.	0.813
HPGDS	ephx1	ENSLOCP00000015904	ENSLOCP00000019580	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Epoxide hydrolase 1, microsomal (xenobiotic).	0.822
HPGDS	gsto1	ENSLOCP00000015904	ENSLOCP00000014599	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Glutathione S-transferase omega 2.	0.937