(81 nodes) PPAR signaling pathway network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102683697	Uncharacterized protein. (145 aa)
	acsbg2	Acyl-CoA synthetase bubblegum family member 2. (875 aa)
	fabp1	Fatty acid binding protein 1a, liver. (127 aa)
	LOC102684941	Retinoid X receptor, gamma b. (466 aa)
	W5M0Y9_LEPOC	Carnitine palmitoyltransferase 1Aa (liver); Belongs to the carnitine/choline acetyltransferase family. (696 aa)
	W5M158_LEPOC	SIK family kinase 3. (1316 aa)
	ufc1	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (167 aa)
	W5M2R3_LEPOC	Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (520 aa)
	W5M3V5_LEPOC	AMP-binding_C domain-containing protein. (218 aa)
	W5M3X4_LEPOC	AMP-binding domain-containing protein. (107 aa)
	angptl4	Angiopoietin-like 4. (469 aa)
	LOC102687169	Fatty acid binding protein 11b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	DBI	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein). (145 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (424 aa)
	LOC102692780	Lipoprotein lipase. (499 aa)
	LOC102692977	PLAT domain-containing protein. (503 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1a. (558 aa)
	acsl3	Acyl-CoA synthetase long chain family member 3b. (719 aa)
	LOC102695553	Nuclear receptor subfamily 1, group I, member 2. (318 aa)
	RXRA	Retinoid X receptor, alpha a. (513 aa)
	acadl	Acyl-CoA dehydrogenase long chain. (411 aa)
	LOC102694877	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (494 aa)
	fabp3	Fatty acid binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	LOC102695076	Cytochrome P450, family 7, subfamily A, polypeptide 1. (518 aa)
	W5MDI6_LEPOC	Uncharacterized protein; Belongs to the cytochrome P450 family. (452 aa)
	LOC102689101	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	LOC102689307	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
	cpt2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (672 aa)
	scp2	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (563 aa)
	W5MGL6_LEPOC	Apolipoprotein A-Ia. (293 aa)
	W5MGM6_LEPOC	Ankyrin repeat domain 24. (1065 aa)
	W5MH03_LEPOC	Nuclear receptor subfamily 1, group H, member 3. (280 aa)
	LOC102697259	Perilipin; Belongs to the perilipin family. (449 aa)
	pltp	Phospholipid transfer protein. (510 aa)
	W5MJ87_LEPOC	Uncharacterized protein. (461 aa)
	LOC102691632	Adiponectin, C1Q and collagen domain containing, b. (266 aa)
	FADS1	Fatty acid desaturase 1. (463 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (623 aa)
	W5MLA0_LEPOC	Aquaporin 10b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (321 aa)
	slc27a6	Solute carrier family 27 member 6. (636 aa)
	LOC102695053	AMP-binding domain-containing protein. (628 aa)
	slc27a1	Solute carrier family 27 member 1a. (647 aa)
	LOC102690084	Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family. (552 aa)
	ucp1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	LOC102694818	Uncharacterized protein; Belongs to the cytochrome P450 family. (294 aa)
	fabp6	Fatty acid binding protein 6, ileal (gastrotropin). (148 aa)
	W5MTJ8_LEPOC	Integrin-linked kinase. (454 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (721 aa)
	me3	Malic enzyme. (619 aa)
	acaa1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	LOC102687850	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (517 aa)
	GK3P	Glycerol kinase 3 pseudogene; Belongs to the FGGY kinase family. (601 aa)
	acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (709 aa)
	acsl6	Uncharacterized protein. (722 aa)
	SCD5	Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (324 aa)
	hmgcs1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa)
	W5MZM4_LEPOC	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (147 aa)
	W5N0N9_LEPOC	Sorbin and SH3 domain containing 1. (1282 aa)
	LOC102683645	Peroxisome proliferator-activated receptor delta b. (438 aa)
	plin2	Perilipin; Belongs to the perilipin family. (432 aa)
	LOC102684444	AMP-binding domain-containing protein. (673 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (728 aa)
	fabp2	Fatty acid binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	LOC102689253	AMP-binding domain-containing protein. (621 aa)
	slc27a2	Solute carrier family 27 member 2a. (621 aa)
	acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (775 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1b. (699 aa)
	W5N8T4_LEPOC	Sorbin and SH3 domain containing 2a. (1413 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (484 aa)
	W5NAN4_LEPOC	Perilipin; Belongs to the perilipin family. (372 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (712 aa)
	W5NC94_LEPOC	Acyl-CoA synthetase bubblegum family member 1. (651 aa)
	W5NCP1_LEPOC	Sorbin and SH3 domain containing 3. (629 aa)
	LOC102689444	Acyl-CoA synthetase long chain family member 2. (704 aa)
	W5NGH4_LEPOC	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (485 aa)
	W5NIQ1_LEPOC	Armadillo repeat containing 2. (861 aa)
	cpt1b	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (791 aa)
	W5NK92_LEPOC	Peroxisome proliferator-activated receptor alpha a. (397 aa)
	me1	Malic enzyme. (588 aa)
	fabp7	Fatty acid binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	W5NMX5_LEPOC	Uncharacterized protein. (47 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBI	acaa1	ENSLOCP00000003856	ENSLOCP00000011938	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.707
DBI	acadl	ENSLOCP00000003856	ENSLOCP00000005611	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Acyl-CoA dehydrogenase long chain.	0.648
DBI	acadm	ENSLOCP00000003856	ENSLOCP00000004158	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Acyl-CoA dehydrogenase medium chain.	0.677
DBI	acox1	ENSLOCP00000003856	ENSLOCP00000016642	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.745
DBI	acox3	ENSLOCP00000003856	ENSLOCP00000012621	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.718
DBI	ehhadh	ENSLOCP00000003856	ENSLOCP00000011711	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.546
DBI	scp2	ENSLOCP00000003856	ENSLOCP00000007446	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.654
FADS1	SCD5	ENSLOCP00000008538	ENSLOCP00000013120	Fatty acid desaturase 1.	Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family.	0.895
FADS1	acox1	ENSLOCP00000008538	ENSLOCP00000016642	Fatty acid desaturase 1.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.519
FADS1	acsl3	ENSLOCP00000008538	ENSLOCP00000004899	Fatty acid desaturase 1.	Acyl-CoA synthetase long chain family member 3b.	0.401
FADS1	acsl4	ENSLOCP00000008538	ENSLOCP00000017866	Fatty acid desaturase 1.	Acyl-CoA synthetase long chain family member 4a.	0.401
GK3P	W5MLA0_LEPOC	ENSLOCP00000012605	ENSLOCP00000009159	Glycerol kinase 3 pseudogene; Belongs to the FGGY kinase family.	Aquaporin 10b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.727
LOC102683645	LOC102684941	ENSLOCP00000014290	ENSLOCP00000001534	Peroxisome proliferator-activated receptor delta b.	Retinoid X receptor, gamma b.	0.924
LOC102683645	LOC102687169	ENSLOCP00000014290	ENSLOCP00000003393	Peroxisome proliferator-activated receptor delta b.	Fatty acid binding protein 11b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.606
LOC102683645	RXRA	ENSLOCP00000014290	ENSLOCP00000005489	Peroxisome proliferator-activated receptor delta b.	Retinoid X receptor, alpha a.	0.923
LOC102683645	W5NMX5_LEPOC	ENSLOCP00000014290	ENSLOCP00000021984	Peroxisome proliferator-activated receptor delta b.	Uncharacterized protein.	0.606
LOC102683645	fabp3	ENSLOCP00000014290	ENSLOCP00000006380	Peroxisome proliferator-activated receptor delta b.	Fatty acid binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.606
LOC102683645	fabp7	ENSLOCP00000014290	ENSLOCP00000021345	Peroxisome proliferator-activated receptor delta b.	Fatty acid binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.606
LOC102684444	LOC102689444	ENSLOCP00000014748	ENSLOCP00000019197	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 2.	0.880
LOC102684444	LOC102692780	ENSLOCP00000014748	ENSLOCP00000004209	AMP-binding domain-containing protein.	Lipoprotein lipase.	0.866