STRINGSTRING
W5NBP5_LEPOC W5NBP5_LEPOC LOC102691582 LOC102691582 W5NKF9_LEPOC W5NKF9_LEPOC W5NKC6_LEPOC W5NKC6_LEPOC HDAC2 HDAC2 W5NJX2_LEPOC W5NJX2_LEPOC ywhaq ywhaq W5NJ26_LEPOC W5NJ26_LEPOC cdkn1b cdkn1b ccnd2 ccnd2 wee2 wee2 W5NH41_LEPOC W5NH41_LEPOC W5NG96_LEPOC W5NG96_LEPOC tgfb2 tgfb2 pcna pcna W5NEN2_LEPOC W5NEN2_LEPOC W5NEM9_LEPOC W5NEM9_LEPOC W5NEJ3_LEPOC W5NEJ3_LEPOC W5NCB6_LEPOC W5NCB6_LEPOC W5NCB3_LEPOC W5NCB3_LEPOC W5NCB0_LEPOC W5NCB0_LEPOC W5NCA9_LEPOC W5NCA9_LEPOC cdk20 cdk20 W5NBC7_LEPOC W5NBC7_LEPOC ccnb3 ccnb3 W5N9Y4_LEPOC W5N9Y4_LEPOC anapc4 anapc4 fbxw12 fbxw12 smad3 smad3 tp53 tp53 LOC102690243 LOC102690243 W5N875_LEPOC W5N875_LEPOC mcm2 mcm2 cdc6 cdc6 cdkn2b cdkn2b cul1 cul1 LOC102695737 LOC102695737 cdc27 cdc27 stag3 stag3 mcm7 mcm7 W5N5D9_LEPOC W5N5D9_LEPOC BUB1B BUB1B skp2 skp2 CDKN2B CDKN2B LOC102682241 LOC102682241 cdkn1a cdkn1a SMAD2 SMAD2 smc3 smc3 LOC102697986 LOC102697986 W5N0P4_LEPOC W5N0P4_LEPOC znf652 znf652 myc myc mad2l1 mad2l1 cdk6 cdk6 LOC102692087 LOC102692087 tgfb3 tgfb3 ccnb1 ccnb1 W5MWB9_LEPOC W5MWB9_LEPOC skp1 skp1 tfdp1 tfdp1 FAM126B FAM126B orc2 orc2 LOC102686431 LOC102686431 zbtb47 zbtb47 W5MTM3_LEPOC W5MTM3_LEPOC cdc25c cdc25c cdkn2c cdkn2c cdc14b cdc14b e2f3 e2f3 anapc10 anapc10 rb1 rb1 W5MPI1_LEPOC W5MPI1_LEPOC bub3 bub3 LOC102693197 LOC102693197 LOC102693673 LOC102693673 LOC102692997 LOC102692997 tfdp2 tfdp2 atr atr W5MML6_LEPOC W5MML6_LEPOC tmem82 tmem82 cdkn2d cdkn2d stag1 stag1 ywhab ywhab rbl1 rbl1 anapc7 anapc7 rbl2 rbl2 W5MJW9_LEPOC W5MJW9_LEPOC ywhae ywhae mynn mynn gsk3b gsk3b W5MIF3_LEPOC W5MIF3_LEPOC snapin snapin cdk1 cdk1 ccne2 ccne2 orc1 orc1 e2f4 e2f4 cdk7 cdk7 W5MG32_LEPOC W5MG32_LEPOC mcm4 mcm4 W5MFQ7_LEPOC W5MFQ7_LEPOC W5MFP6_LEPOC W5MFP6_LEPOC mad2l2 mad2l2 ccne1 ccne1 orc6 orc6 E2F2 E2F2 zbtb46 zbtb46 ccnd1 ccnd1 anapc5 anapc5 cdc7 cdc7 anapc13 anapc13 gadd45a gadd45a CDK2 CDK2 cdk4 cdk4 cdc20 cdc20 chek2 chek2 W5M7W2_LEPOC W5M7W2_LEPOC wee1 wee1 W5M661_LEPOC W5M661_LEPOC ccna2 ccna2 ywhag ywhag W5M4I2_LEPOC W5M4I2_LEPOC cdc16 cdc16 crebbp crebbp hdac1 hdac1 CDC20B CDC20B W5M3B8_LEPOC W5M3B8_LEPOC ccnh ccnh cdc45 cdc45 mad1l1 mad1l1 orc4 orc4 W5LZK6_LEPOC W5LZK6_LEPOC W5LZJ8_LEPOC W5LZJ8_LEPOC W5LYX0_LEPOC W5LYX0_LEPOC CDC25B CDC25B ap5s1 ap5s1 W5LYD5_LEPOC W5LYD5_LEPOC chek1 chek1 LOC102682951 LOC102682951 mcm6 mcm6 gadd45b gadd45b anapc2 anapc2 cdc26 cdc26 cdc14a cdc14a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5NBP5_LEPOCCyclin N-terminal domain containing 2; Belongs to the cyclin family. (388 aa)
LOC102691582Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family. (225 aa)
W5NKF9_LEPOCStructural maintenance of chromosomes protein. (1233 aa)
W5NKC6_LEPOCTtk protein kinase. (850 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (490 aa)
W5NJX2_LEPOCOrigin recognition complex, subunit 3. (728 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family. (260 aa)
W5NJ26_LEPOCUncharacterized protein. (1181 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Ba. (195 aa)
ccnd2Cyclin D2, b; Belongs to the cyclin family. (296 aa)
wee2Wee1-like protein kinase. (582 aa)
W5NH41_LEPOCE3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
W5NG96_LEPOCDNA helicase; Belongs to the MCM family. (815 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (409 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (264 aa)
W5NEN2_LEPOCAnaphase promoting complex subunit 1. (948 aa)
W5NEM9_LEPOCAnaphase promoting complex subunit 1. (925 aa)
W5NEJ3_LEPOCOrigin recognition complex, subunit 5. (375 aa)
W5NCB6_LEPOCSMC_N domain-containing protein. (329 aa)
W5NCB3_LEPOCUncharacterized protein. (150 aa)
W5NCB0_LEPOCUncharacterized protein. (121 aa)
W5NCA9_LEPOCSMC_N domain-containing protein. (150 aa)
cdk20Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (344 aa)
W5NBC7_LEPOCStromal antigen 2b. (1273 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (419 aa)
W5N9Y4_LEPOCTransforming growth factor beta; Belongs to the TGF-beta family. (392 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
fbxw12Si:ch73-142c19.1. (482 aa)
smad3Mothers against decapentaplegic homolog. (427 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
LOC102690243Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (332 aa)
W5N875_LEPOCCyclin B2; Belongs to the cyclin family. (394 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (128 aa)
cul1Cullin 1a; Belongs to the cullin family. (777 aa)
LOC102695737DNA helicase; Belongs to the MCM family. (834 aa)
cdc27Cell division cycle 27. (830 aa)
stag3SCD domain-containing protein. (1258 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (721 aa)
W5N5D9_LEPOCMothers against decapentaplegic homolog. (547 aa)
BUB1BBUB1 N-terminal domain-containing protein. (1083 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (414 aa)
CDKN2BANK_REP_REGION domain-containing protein. (125 aa)
LOC102682241ANK_REP_REGION domain-containing protein. (166 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (156 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
LOC102697986DNA helicase; Belongs to the MCM family. (814 aa)
W5N0P4_LEPOCE1A binding protein p300 a. (2068 aa)
znf652Zinc finger protein 652. (668 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (404 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (252 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (323 aa)
LOC102692087Fizzy/cell division cycle 20 related 1b. (486 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (398 aa)
W5MWB9_LEPOCDBF4 zinc finger. (622 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
tfdp1Transcription factor. (407 aa)
FAM126BFamily with sequence similarity 126 member B. (540 aa)
orc2Origin recognition complex, subunit 2. (576 aa)
LOC10268643114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
zbtb47Uncharacterized protein. (713 aa)
W5MTM3_LEPOCCDC23 (cell division cycle 23, yeast, homolog). (569 aa)
cdc25cUncharacterized protein. (201 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (179 aa)
cdc14bUncharacterized protein. (553 aa)
e2f3E2F transcription factor 3. (425 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
rb1Retinoblastoma 1. (932 aa)
W5MPI1_LEPOCCyclin A1; Belongs to the cyclin family. (401 aa)
bub3BUB3 mitotic checkpoint protein. (329 aa)
LOC102693197Growth arrest and DNA-damage-inducible, gamma a. (172 aa)
LOC102693673Ribosomal_L7Ae domain-containing protein. (161 aa)
LOC102692997Growth arrest and DNA damage inducible gamma. (200 aa)
tfdp2Transcription factor. (446 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2649 aa)
W5MML6_LEPOCZinc finger and BTB domain containing 17. (727 aa)
tmem82Transmembrane protein 82. (274 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (174 aa)
stag1Stromal antigen 1a. (1275 aa)
ywhabTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a; Belongs to the 14-3-3 family. (246 aa)
rbl1Retinoblastoma-like 1 (p107). (1071 aa)
anapc7Anaphase promoting complex subunit 7. (567 aa)
rbl2Retinoblastoma-like 2 (p130). (1102 aa)
W5MJW9_LEPOCExtra spindle pole bodies like 1, separase. (2035 aa)
ywhaeTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (285 aa)
mynnUncharacterized protein. (626 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (420 aa)
W5MIF3_LEPOCMothers against decapentaplegic homolog. (556 aa)
snapinSNAP associated protein. (199 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (919 aa)
e2f4E2F transcription factor 4. (409 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (348 aa)
W5MG32_LEPOCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4160 aa)
mcm4DNA helicase; Belongs to the MCM family. (678 aa)
W5MFQ7_LEPOCSyntaphilin b. (577 aa)
W5MFP6_LEPOCRAD21 cohesin complex component like 1. (596 aa)
mad2l2Mitotic arrest deficient 2 like 2. (211 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (412 aa)
orc6Origin recognition complex, subunit 6. (256 aa)
E2F2E2F transcription factor 2. (177 aa)
zbtb46Zinc finger and BTB domain containing 46. (597 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (296 aa)
anapc5Anaphase promoting complex subunit 5. (769 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (545 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (159 aa)
CDK2Cyclin dependent kinase 2. (252 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (305 aa)
cdc20Cell division cycle 20 homolog. (512 aa)
chek2Checkpoint kinase 2. (518 aa)
W5M7W2_LEPOCCell division cycle 25 homolog d. (386 aa)
wee1Wee1-like protein kinase. (619 aa)
W5M661_LEPOCRAD21 cohesin complex component a. (645 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
ywhag3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
W5M4I2_LEPOCZinc finger and BTB domain containing 10. (728 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (629 aa)
crebbpCREB binding protein b. (2500 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
CDC20BCell division cycle 20B. (510 aa)
W5M3B8_LEPOCSi:ch211-269e2.1. (1164 aa)
ccnhCyclin H; Belongs to the cyclin family. (322 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
mad1l1Mitotic arrest deficient 1 like 1. (715 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
W5LZK6_LEPOCNon-specific serine/threonine protein kinase. (3061 aa)
W5LZJ8_LEPOCFizzy/cell division cycle 20 related 1a. (528 aa)
W5LYX0_LEPOCTransforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
CDC25BCell division cycle 25B. (574 aa)
ap5s1Adaptor related protein complex 5 subunit sigma 1. (206 aa)
W5LYD5_LEPOCE2F transcription factor 1. (431 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
LOC102682951Cyclin-dependent kinase inhibitor 1Cb. (222 aa)
mcm6DNA helicase; Belongs to the MCM family. (819 aa)
gadd45bGrowth arrest and DNA-damage-inducible, beta a. (174 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (785 aa)
cdc26Cell division cycle 26 homolog. (88 aa)
cdc14aCell division cycle 14Ab. (620 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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