(93 nodes) Mitophagy - animal network (Lepisosteus oculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	jun	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (322 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	W5LXB6_LEPOC	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (157 aa)
	tbc1d17	TBC1 domain family, member 17. (587 aa)
	W5LYD5_LEPOC	E2F transcription factor 1. (431 aa)
	LOC102698806	Zgc:73226. (182 aa)
	W5LZ01_LEPOC	Mitofusin 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (667 aa)
	LOC102683012	Uncharacterized protein. (223 aa)
	W5M0H1_LEPOC	PAS domain-containing protein. (197 aa)
	LOC102688879	Serine/threonine kinase 35; Belongs to the protein kinase superfamily. (415 aa)
	mras	Muscle RAS oncogene homolog. (210 aa)
	fundc1	FUN14 domain containing 1. (153 aa)
	pink1	PTEN induced kinase 1. (581 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (153 aa)
	csnk2a1	Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (392 aa)
	LOC102697324	Tyrosine-protein kinase. (542 aa)
	cfap70	Cilia and flagella associated protein 70. (1123 aa)
	pgam5	PGAM family member 5, serine/threonine protein phosphatase, mitochondrial. (306 aa)
	GABARAPL2	GABA(A) receptor-associated protein like 2. (121 aa)
	rras2	RAS related 2. (202 aa)
	pdik1l	PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (347 aa)
	rhot2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (631 aa)
	csnk2a2	Casein kinase 2, alpha prime polypeptide b; Belongs to the protein kinase superfamily. (393 aa)
	usp31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1308 aa)
	mapk8	Mitogen-activated protein kinase. (384 aa)
	usp30	Ubiquitin carboxyl-terminal hydrolase. (524 aa)
	rrad	Ras-related associated with diabetes. (310 aa)
	W5MCY1_LEPOC	Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. (1605 aa)
	mfn2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	W5ME60_LEPOC	Autophagy/beclin-1 regulator 1a. (1252 aa)
	LOC102694650	Zgc:110699. (219 aa)
	W5MEM1_LEPOC	Sp1 transcription factor. (691 aa)
	bcl2l1	BCL2 like 1. (222 aa)
	ulk1	Unc-51 like autophagy activating kinase 1a. (1028 aa)
	W5MHT6_LEPOC	RAS (RAD and GEM)-like GTP-binding 1. (301 aa)
	LOC102684075	Casein kinase 2, alpha 1 polypeptide; Belongs to the protein kinase superfamily. (392 aa)
	bnip3	BCL2 interacting protein 3. (198 aa)
	W5MMI2_LEPOC	Spen family transcriptional repressor. (3595 aa)
	LOC102692047	Zgc:92606. (117 aa)
	LOC102693433	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (806 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1095 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
	NPAS3	Neuronal PAS domain protein 3. (955 aa)
	agfg1	ArfGAP with FG repeats 1b. (592 aa)
	mitf	Melanocyte inducing transcription factor b. (509 aa)
	LOC102691138	Mitogen-activated protein kinase. (423 aa)
	gem	GTP binding protein overexpressed in skeletal muscle. (240 aa)
	cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2. (240 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (419 aa)
	CSDE1	Cold shock domain containing E1. (900 aa)
	nras	NRAS proto-oncogene, GTPase. (189 aa)
	usp4	Ubiquitin specific peptidase 4 (proto-oncogene); Belongs to the peptidase C19 family. (1030 aa)
	W5MZ31_LEPOC	Activating transcription factor 4b. (411 aa)
	becn1	Beclin 1, autophagy related. (449 aa)
	sqstm1	Sequestosome 1. (440 aa)
	TOMM7	Translocase of outer mitochondrial membrane 7. (50 aa)
	W5N1V1_LEPOC	Tax1 (human T-cell leukemia virus type I) binding protein 1b. (843 aa)
	mapk10	Mitogen-activated protein kinase. (469 aa)
	tfeb	Transcription factor EB. (488 aa)
	W5N2W4_LEPOC	NBR1 autophagy cargo receptor b. (988 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1075 aa)
	W5N6A2_LEPOC	Ubiquitin specific peptidase 19; Belongs to the peptidase C19 family. (1429 aa)
	usp43	Ubiquitin specific peptidase 43b; Belongs to the peptidase C19 family. (1188 aa)
	rhot1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (696 aa)
	fundc2	Fun14 domain containing 2. (160 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (395 aa)
	fis1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (158 aa)
	rasl11b	RAS-like, family 11, member B. (237 aa)
	W5NAL6_LEPOC	Hypoxia inducible factor 1 subunit alpha, like. (630 aa)
	gabarap	GABA(A) receptor-associated protein a. (143 aa)
	rab7a	RAB7A, member RAS oncogene family. (208 aa)
	W5NBB7_LEPOC	DUSP domain-containing protein. (229 aa)
	tfe3	Transcription factor binding to IGHM enhancer 3a. (590 aa)
	LOC102698928	Si:dkey-13a21.4. (205 aa)
	npas1	Neuronal PAS domain protein 1. (709 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	rps27a	Ribosomal protein S27a. (162 aa)
	LOC102697663	Zgc:100918. (206 aa)
	optn	Optineurin. (582 aa)
	tfec	Transcription factor EC. (444 aa)
	LOC102690577	BCL2 interacting protein 3 like a. (217 aa)
	LOC102689161	JunE proto-oncogene, AP-1 transcription factor subunit. (349 aa)
	W5NGW5_LEPOC	V-rel avian reticuloendotheliosis viral oncogene homolog. (605 aa)
	W5NHC7_LEPOC	TBC1 domain family, member 15. (668 aa)
	epas1	Endothelial PAS domain protein 1b. (852 aa)
	tbk1	TANK-binding kinase 1. (731 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (468 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
	W5NIN0_LEPOC	BCL2 like 13. (494 aa)
	FOXO3	Forkhead box O3. (676 aa)
	LOC102683020	Tyrosine-protein kinase. (479 aa)
	USP15	Ubiquitin carboxyl-terminal hydrolase. (993 aa)

Your Current Organism:

Lepisosteus oculatus

NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	LOC102691138	ENSLOCP00000012772	ENSLOCP00000012317	Cold shock domain containing E1.	Mitogen-activated protein kinase.	0.749
CSDE1	LOC102697324	ENSLOCP00000012772	ENSLOCP00000002706	Cold shock domain containing E1.	Tyrosine-protein kinase.	0.582
CSDE1	W5NGW5_LEPOC	ENSLOCP00000012772	ENSLOCP00000019874	Cold shock domain containing E1.	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.407
CSDE1	bcl2l1	ENSLOCP00000012772	ENSLOCP00000007383	Cold shock domain containing E1.	BCL2 like 1.	0.648
CSDE1	mapk10	ENSLOCP00000012772	ENSLOCP00000014792	Cold shock domain containing E1.	Mitogen-activated protein kinase.	0.669
CSDE1	mapk8	ENSLOCP00000012772	ENSLOCP00000004744	Cold shock domain containing E1.	Mitogen-activated protein kinase.	0.669
CSDE1	mras	ENSLOCP00000012772	ENSLOCP00000002184	Cold shock domain containing E1.	Muscle RAS oncogene homolog.	0.512
CSDE1	pink1	ENSLOCP00000012772	ENSLOCP00000002266	Cold shock domain containing E1.	PTEN induced kinase 1.	0.446
CSDE1	prkn	ENSLOCP00000012772	ENSLOCP00000020388	Cold shock domain containing E1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.481
CSDE1	rps27a	ENSLOCP00000012772	ENSLOCP00000019146	Cold shock domain containing E1.	Ribosomal protein S27a.	0.630
CSDE1	rras2	ENSLOCP00000012772	ENSLOCP00000003801	Cold shock domain containing E1.	RAS related 2.	0.656
CSDE1	uba52	ENSLOCP00000012772	ENSLOCP00000002515	Cold shock domain containing E1.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.624
FOXO3	LOC102691138	ENSLOCP00000020509	ENSLOCP00000012317	Forkhead box O3.	Mitogen-activated protein kinase.	0.891
FOXO3	cited2	ENSLOCP00000020509	ENSLOCP00000022213	Forkhead box O3.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2.	0.864
FOXO3	mapk10	ENSLOCP00000020509	ENSLOCP00000014792	Forkhead box O3.	Mitogen-activated protein kinase.	0.836
FOXO3	mapk8	ENSLOCP00000020509	ENSLOCP00000004744	Forkhead box O3.	Mitogen-activated protein kinase.	0.836
FOXO3	pink1	ENSLOCP00000020509	ENSLOCP00000002266	Forkhead box O3.	PTEN induced kinase 1.	0.518
FOXO3	tbk1	ENSLOCP00000020509	ENSLOCP00000020366	Forkhead box O3.	TANK-binding kinase 1.	0.422
FOXO3	tp53	ENSLOCP00000020509	ENSLOCP00000017063	Forkhead box O3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.620
GABARAPL2	LOC102688879	ENSLOCP00000003596	ENSLOCP00000002099	GABA(A) receptor-associated protein like 2.	Serine/threonine kinase 35; Belongs to the protein kinase superfamily.	0.775