STRINGSTRING
hmgb1 hmgb1 ttc14 ttc14 hras hras ctsb ctsb W5LXQ6_LEPOC W5LXQ6_LEPOC LOC102698806 LOC102698806 W5LYQ5_LEPOC W5LYQ5_LEPOC pik3ca pik3ca W5LZ16_LEPOC W5LZ16_LEPOC LOC102683012 LOC102683012 W5M000_LEPOC W5M000_LEPOC pik3r2 pik3r2 pik3r4 pik3r4 W5M0H1_LEPOC W5M0H1_LEPOC W5M0R4_LEPOC W5M0R4_LEPOC atg3 atg3 LOC102688879 LOC102688879 dapk3 dapk3 mras mras mapk1 mapk1 W5M1Z0_LEPOC W5M1Z0_LEPOC rasef rasef W5M2S9_LEPOC W5M2S9_LEPOC ctsd ctsd atg16l2 atg16l2 camkk1 camkk1 lmln lmln LOC102696535 LOC102696535 W5M558_LEPOC W5M558_LEPOC MTMR4 MTMR4 GABARAPL2 GABARAPL2 tsc2 tsc2 rras2 rras2 pdik1l pdik1l LOC102695725 LOC102695725 LOC102695918 LOC102695918 pdpk1 pdpk1 rps6kb1 rps6kb1 vmp1 vmp1 mapk8 mapk8 pik3cb pik3cb tp53inp2 tp53inp2 wipi2 wipi2 W5MBD8_LEPOC W5MBD8_LEPOC smcr8 smcr8 rrad rrad stk11 stk11 mlst8 mlst8 ddit4 ddit4 ulk2 ulk2 stx17 stx17 W5ME60_LEPOC W5ME60_LEPOC LOC102694650 LOC102694650 W5MEI9_LEPOC W5MEI9_LEPOC atg13 atg13 LOC102697582 LOC102697582 wdr41 wdr41 W5MEY8_LEPOC W5MEY8_LEPOC pik3r3 pik3r3 rragc rragc rb1cc1 rb1cc1 LOC102697452 LOC102697452 map2k2 map2k2 bcl2l1 bcl2l1 pten pten ulk1 ulk1 NOL4 NOL4 tp53inp1 tp53inp1 mtor mtor atg4b atg4b W5MHT6_LEPOC W5MHT6_LEPOC atg4c atg4c rab39a rab39a nrbf2 nrbf2 zfyve28 zfyve28 W5MJ15_LEPOC W5MJ15_LEPOC camkk2 camkk2 W5MJN0_LEPOC W5MJN0_LEPOC W5MKK4_LEPOC W5MKK4_LEPOC mtmr3 mtmr3 LOC102694099 LOC102694099 bnip3 bnip3 rhebl1 rhebl1 atg4d atg4d dus2 dus2 atg12 atg12 LOC102692047 LOC102692047 prkacb prkacb W5MPN4_LEPOC W5MPN4_LEPOC W5MPR2_LEPOC W5MPR2_LEPOC tank tank LOC102693076 LOC102693076 prkaa2 prkaa2 deptor deptor snap47 snap47 LOC102693433 LOC102693433 atg16l1 atg16l1 eif2ak3 eif2ak3 pik3c3 pik3c3 atg9a atg9a NPAS3 NPAS3 lamp1 lamp1 cflar cflar LOC102694874 LOC102694874 LOC102695073 LOC102695073 W5MV05_LEPOC W5MV05_LEPOC crygn crygn rheb rheb LOC102691138 LOC102691138 gem gem HIF1A HIF1A prkx prkx PPP2CA PPP2CA CSDE1 CSDE1 nras nras W5MWV1_LEPOC W5MWV1_LEPOC pik3r1 pik3r1 rab33b rab33b W5MXR6_LEPOC W5MXR6_LEPOC ppp2cb ppp2cb ATG2B ATG2B ttc33 ttc33 becn1 becn1 dapk1 dapk1 sqstm1 sqstm1 atg14 atg14 LOC102698141 LOC102698141 mapk10 mapk10 c9orf72 c9orf72 W5N3H9_LEPOC W5N3H9_LEPOC wipi1 wipi1 bcl2 bcl2 W5N4K6_LEPOC W5N4K6_LEPOC W5N4L0_LEPOC W5N4L0_LEPOC RAB7B RAB7B akt1 akt1 W5N7F7_LEPOC W5N7F7_LEPOC W5N7Y0_LEPOC W5N7Y0_LEPOC hmgb2 hmgb2 mtmr14 mtmr14 ERN1 ERN1 map2k1 map2k1 atg7 atg7 rab43 rab43 rasl11b rasl11b eif2s1 eif2s1 LOC102687212 LOC102687212 W5NAL6_LEPOC W5NAL6_LEPOC igf1r igf1r W5NAZ8_LEPOC W5NAZ8_LEPOC prkcd prkcd gabarap gabarap LOC102690661 LOC102690661 W5NB45_LEPOC W5NB45_LEPOC rab7a rab7a akt2 akt2 LOC102684782 LOC102684782 igbp1 igbp1 LOC102698928 LOC102698928 dapk2 dapk2 npas1 npas1 rab39b rab39b LOC102690405 LOC102690405 W5NDQ8_LEPOC W5NDQ8_LEPOC kras kras rab33a rab33a W5NE85_LEPOC W5NE85_LEPOC LOC102697663 LOC102697663 prkcq prkcq LOC107077995 LOC107077995 rab1a rab1a kcnk1 kcnk1 epas1 epas1 tbk1 tbk1 atg5 atg5 map3k7 map3k7 W5NLK8_LEPOC W5NLK8_LEPOC irs4 irs4 tssk6 tssk6 W5NMP3_LEPOC W5NMP3_LEPOC TSSK1B TSSK1B W5NNT4_LEPOC W5NNT4_LEPOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hmgb1High mobility group box 1a. (212 aa)
ttc14Tetratricopeptide repeat domain 14. (757 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
ctsbCathepsin Ba; Belongs to the peptidase C1 family. (331 aa)
W5LXQ6_LEPOCUncharacterized protein. (228 aa)
LOC102698806Zgc:73226. (182 aa)
W5LYQ5_LEPOCTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1087 aa)
W5LZ16_LEPOCC2H2-type domain-containing protein. (510 aa)
LOC102683012Uncharacterized protein. (223 aa)
W5M000_LEPOCCathepsin 12; Belongs to the peptidase C1 family. (367 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (729 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1377 aa)
W5M0H1_LEPOCPAS domain-containing protein. (197 aa)
W5M0R4_LEPOCUncharacterized protein. (193 aa)
atg3Autophagy-related protein 3. (315 aa)
LOC102688879Serine/threonine kinase 35; Belongs to the protein kinase superfamily. (415 aa)
dapk3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (463 aa)
mrasMuscle RAS oncogene homolog. (210 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
W5M1Z0_LEPOCUncharacterized protein. (152 aa)
rasefRAS and EF-hand domain containing. (704 aa)
W5M2S9_LEPOCSynaptosome associated protein 29. (198 aa)
ctsdCathepsin D; Belongs to the peptidase A1 family. (398 aa)
atg16l2WD_REPEATS_REGION domain-containing protein. (613 aa)
camkk1Calcium/calmodulin-dependent protein kinase kinase 1, alpha a. (503 aa)
lmlnLeishmanolysin-like peptidase. (658 aa)
LOC102696535Si:dkeyp-97e7.9. (417 aa)
W5M558_LEPOCCrystallin, beta B3; Belongs to the beta/gamma-crystallin family. (235 aa)
MTMR4Myotubularin related protein 4. (1153 aa)
GABARAPL2GABA(A) receptor-associated protein like 2. (121 aa)
tsc2TSC complex subunit 2. (1854 aa)
rras2RAS related 2. (202 aa)
pdik1lPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (347 aa)
LOC102695725RAB42, member RAS oncogene family a. (212 aa)
LOC102695918Si:dkey-34d22.5. (215 aa)
pdpk13-phosphoinositide dependent protein kinase 1a. (558 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (508 aa)
vmp1Vacuole membrane protein 1. (408 aa)
mapk8Mitogen-activated protein kinase. (384 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
tp53inp2Tumor protein p53 inducible nuclear protein 2. (225 aa)
wipi2WD repeat domain, phosphoinositide interacting 2. (426 aa)
W5MBD8_LEPOCUV radiation resistance associated gene. (669 aa)
smcr8Smith-Magenis syndrome chromosome region, candidate 8a. (926 aa)
rradRas-related associated with diabetes. (310 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (443 aa)
mlst8MTOR associated protein, LST8 homolog (S. cerevisiae). (328 aa)
ddit4DNA-damage-inducible transcript 4. (229 aa)
ulk2Unc-51 like autophagy activating kinase 2. (1044 aa)
stx17Syntaxin 17; Belongs to the syntaxin family. (329 aa)
W5ME60_LEPOCAutophagy/beclin-1 regulator 1a. (1252 aa)
LOC102694650Zgc:110699. (219 aa)
W5MEI9_LEPOCSi:ch211-260e23.9. (171 aa)
atg13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (547 aa)
LOC102697582TSC complex subunit 1a. (1189 aa)
wdr41WD repeat domain 41. (448 aa)
W5MEY8_LEPOCNucleolar protein 4-like b. (674 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (739 aa)
rragcRas-related GTP binding Ca. (380 aa)
rb1cc1RB1-inducible coiled-coil 1. (1604 aa)
LOC102697452Zgc:101559. (234 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (400 aa)
bcl2l1BCL2 like 1. (222 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (417 aa)
ulk1Unc-51 like autophagy activating kinase 1a. (1028 aa)
NOL4Nucleolar protein 4. (630 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (243 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
atg4bCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (406 aa)
W5MHT6_LEPOCRAS (RAD and GEM)-like GTP-binding 1. (301 aa)
atg4cCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (459 aa)
rab39aUncharacterized protein. (213 aa)
nrbf2Nuclear receptor binding factor 2b. (269 aa)
zfyve28Zinc finger, FYVE domain containing 28. (978 aa)
W5MJ15_LEPOCPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1075 aa)
camkk2Si:ch73-62l21.1. (593 aa)
W5MJN0_LEPOCNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (492 aa)
W5MKK4_LEPOCSi:dkey-240h12.4; Belongs to the protein kinase superfamily. (301 aa)
mtmr3Myotubularin related protein 3. (1198 aa)
LOC102694099Protein kinase domain-containing protein. (308 aa)
bnip3BCL2 interacting protein 3. (198 aa)
rhebl1Ras homolog, mTORC1 binding like 1. (184 aa)
atg4dCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (503 aa)
dus2Dihydrouridine synthase 2. (498 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (72 aa)
LOC102692047Zgc:92606. (117 aa)
prkacbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (396 aa)
W5MPN4_LEPOCRubicon autophagy regulator. (928 aa)
W5MPR2_LEPOCSPT20 homolog, SAGA complex component. (814 aa)
tankTRAF family member-associated NFKB activator. (317 aa)
LOC102693076Transmembrane phosphatase with tensin homology. (513 aa)
prkaa2Non-specific serine/threonine protein kinase. (551 aa)
deptorDEP domain containing MTOR-interacting protein. (413 aa)
snap47Synaptosome associated protein 47. (426 aa)
LOC102693433Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (806 aa)
atg16l1ATG16 autophagy related 16-like 1 (S. cerevisiae). (623 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1095 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (860 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
NPAS3Neuronal PAS domain protein 3. (955 aa)
lamp1Lysosomal associated membrane protein 1a. (424 aa)
cflarCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (471 aa)
LOC102694874Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
LOC102695073Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (133 aa)
W5MV05_LEPOCUncharacterized protein; Belongs to the protein kinase superfamily. (344 aa)
crygnCrystallin, gamma N1; Belongs to the beta/gamma-crystallin family. (186 aa)
rhebRas homolog, mTORC1 binding. (184 aa)
LOC102691138Mitogen-activated protein kinase. (423 aa)
gemGTP binding protein overexpressed in skeletal muscle. (240 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (419 aa)
prkxProtein kinase X-linked. (362 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CSDE1Cold shock domain containing E1. (900 aa)
nrasNRAS proto-oncogene, GTPase. (189 aa)
W5MWV1_LEPOCRubicon like autophagy enhancer. (484 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (729 aa)
rab33bRAB33B, member RAS oncogene family a. (231 aa)
W5MXR6_LEPOCSi:ch73-234b20.5. (104 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
ATG2BAutophagy related 2B. (2085 aa)
ttc33Non-specific serine/threonine protein kinase. (561 aa)
becn1Beclin 1, autophagy related. (449 aa)
dapk1Death-associated protein kinase 1. (1431 aa)
sqstm1Sequestosome 1. (440 aa)
atg14Autophagy related 14. (685 aa)
LOC102698141FYVE-type domain-containing protein. (687 aa)
mapk10Mitogen-activated protein kinase. (469 aa)
c9orf72Zgc:100846. (461 aa)
W5N3H9_LEPOCZinc finger, FYVE domain containing 1. (770 aa)
wipi1WD repeat domain, phosphoinositide interacting 1. (450 aa)
bcl2BCL2 apoptosis regulator b. (231 aa)
W5N4K6_LEPOCUncharacterized protein. (623 aa)
W5N4L0_LEPOCUncharacterized protein. (303 aa)
RAB7BRAB7B, member RAS oncogene family. (200 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
W5N7F7_LEPOCRegulatory associated protein of MTOR, complex 1. (1375 aa)
W5N7Y0_LEPOCZgc:158659; Belongs to the PI3/PI4-kinase family. (902 aa)
hmgb2High mobility group box 2a. (219 aa)
mtmr14Myotubularin related protein 14. (649 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (709 aa)
rab43RAB43, member RAS oncogene family. (207 aa)
rasl11bRAS-like, family 11, member B. (237 aa)
eif2s1Eukaryotic translation initiation factor 2, subunit 1 alpha a. (316 aa)
LOC102687212Zgc:162879. (684 aa)
W5NAL6_LEPOCHypoxia inducible factor 1 subunit alpha, like. (630 aa)
igf1rTyrosine-protein kinase receptor. (1180 aa)
W5NAZ8_LEPOCCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (420 aa)
prkcdProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
gabarapGABA(A) receptor-associated protein a. (143 aa)
LOC102690661Si:ch211-11n16.2. (658 aa)
W5NB45_LEPOCHigh mobility group box 3a. (214 aa)
rab7aRAB7A, member RAS oncogene family. (208 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC102684782Zgc:171927. (213 aa)
igbp1Immunoglobulin (CD79A) binding protein 1. (358 aa)
LOC102698928Si:dkey-13a21.4. (205 aa)
dapk2Death-associated protein kinase 2a; Belongs to the protein kinase superfamily. (495 aa)
npas1Neuronal PAS domain protein 1. (709 aa)
rab39bRAB39B, member RAS oncogene family b. (217 aa)
LOC102690405Ras-related GTP binding A. (315 aa)
W5NDQ8_LEPOCLysosomal-associated membrane protein 2. (437 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
rab33aRAB33A, member RAS oncogene family. (241 aa)
W5NE85_LEPOCNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (469 aa)
LOC102697663Zgc:100918. (206 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
LOC107077995Uncharacterized protein. (950 aa)
rab1aRAB1A, member RAS oncogene family a. (205 aa)
kcnk1Potassium channel subfamily K member. (337 aa)
epas1Endothelial PAS domain protein 1b. (852 aa)
tbk1TANK-binding kinase 1. (731 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (277 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (653 aa)
W5NLK8_LEPOCInsulin receptor substrate 1. (1079 aa)
irs4Insulin receptor substrate 4a. (1038 aa)
tssk6Testis-specific serine kinase 6; Belongs to the protein kinase superfamily. (272 aa)
W5NMP3_LEPOCInsulin receptor substrate 2b. (1069 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (354 aa)
W5NNT4_LEPOCAutophagy related 101. (138 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
Server load: low (22%) [HD]