STRINGSTRING
adcy2 adcy2 hras hras gng7 gng7 W5LZ17_LEPOC W5LZ17_LEPOC gng3 gng3 W5M045_LEPOC W5M045_LEPOC pik3r4 pik3r4 LOC102698371 LOC102698371 ccn5 ccn5 mef2c mef2c mras mras PRKAB2 PRKAB2 LOC107075842 LOC107075842 LOC102694849 LOC102694849 mapk1 mapk1 adcy5 adcy5 adcy9 adcy9 gng10 gng10 GABARAPL2 GABARAPL2 pde3b pde3b rras2 rras2 nos1 nos1 W5M7C3_LEPOC W5M7C3_LEPOC klf2 klf2 rps6kb1 rps6kb1 W5M935_LEPOC W5M935_LEPOC NOS3 NOS3 mef2b mef2b cdh1 cdh1 W5MC12_LEPOC W5MC12_LEPOC rrad rrad ccnd1 ccnd1 W5MDZ0_LEPOC W5MDZ0_LEPOC mylk mylk W5MEC4_LEPOC W5MEC4_LEPOC nos2 nos2 map2k2 map2k2 LOC102689101 LOC102689101 CALML6 CALML6 LOC102689307 LOC102689307 LOC102696120 LOC102696120 mylk2 mylk2 gnb1 gnb1 mtor mtor W5MHD6_LEPOC W5MHD6_LEPOC W5MHT6_LEPOC W5MHT6_LEPOC snapin snapin W5MIF3_LEPOC W5MIF3_LEPOC W5MJN0_LEPOC W5MJN0_LEPOC W5MJS7_LEPOC W5MJS7_LEPOC adcy7 adcy7 W5MKY0_LEPOC W5MKY0_LEPOC prkag1 prkag1 gnb3 gnb3 W5MNE8_LEPOC W5MNE8_LEPOC LOC102692047 LOC102692047 prkacb prkacb W5MPS8_LEPOC W5MPS8_LEPOC prkaa2 prkaa2 CALM1 CALM1 W5MRU6_LEPOC W5MRU6_LEPOC ucp1 ucp1 W5MSI7_LEPOC W5MSI7_LEPOC W5MSJ8_LEPOC W5MSJ8_LEPOC pik3c3 pik3c3 myl3 myl3 egr1 egr1 LOC102686598 LOC102686598 klf4 klf4 W5MV05_LEPOC W5MV05_LEPOC gng5 gng5 gem gem camk4 camk4 CSDE1 CSDE1 nras nras tgfbr1 tgfbr1 gnai2 gnai2 LOC102694494 LOC102694494 prkag3 prkag3 itpr1 itpr1 W5MZ39_LEPOC W5MZ39_LEPOC ttc33 ttc33 becn1 becn1 HDAC9 HDAC9 W5N1X5_LEPOC W5N1X5_LEPOC gng2 gng2 LOC102690587 LOC102690587 ppargc1a ppargc1a SMAD2 SMAD2 itpr3 itpr3 LOC102688108 LOC102688108 RYR3 RYR3 prkag2 prkag2 adcy8 adcy8 akt1 akt1 PLCB2 PLCB2 W5N5D9_LEPOC W5N5D9_LEPOC LOC102691822 LOC102691822 W5N5S6_LEPOC W5N5S6_LEPOC gngt2 gngt2 W5N676_LEPOC W5N676_LEPOC adcy1 adcy1 LOC102699081 LOC102699081 myl4 myl4 W5N6Q5_LEPOC W5N6Q5_LEPOC W5N6R2_LEPOC W5N6R2_LEPOC pik3r5 pik3r5 gnb5 gnb5 SPHK1 SPHK1 W5N7N1_LEPOC W5N7N1_LEPOC map2k1 map2k1 smad3 smad3 W5N977_LEPOC W5N977_LEPOC slc8a3 slc8a3 serpine1 serpine1 W5NAB3_LEPOC W5NAB3_LEPOC W5NAH0_LEPOC W5NAH0_LEPOC W5NAN4_LEPOC W5NAN4_LEPOC mef2a mef2a gabarap gabarap akt2 akt2 calm1 calm1 gng8 gng8 W5NCY7_LEPOC W5NCY7_LEPOC apln apln W5NDZ4_LEPOC W5NDZ4_LEPOC kras kras W5NE85_LEPOC W5NE85_LEPOC W5NF09_LEPOC W5NF09_LEPOC slc8a1 slc8a1 pik3cg pik3cg adcy3 adcy3 nrf1 nrf1 GNAI1 GNAI1 CALM2 CALM2 prkce prkce PLCB4 PLCB4 PLCB1 PLCB1 W5NIQ4_LEPOC W5NIQ4_LEPOC LOC102694194 LOC102694194 ccn2 ccn2 W5NLD7_LEPOC W5NLD7_LEPOC agtr1 agtr1 LOC102685279 LOC102685279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adcy2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
W5LZ17_LEPOCGuanine nucleotide binding protein (G protein), beta polypeptide 4b. (326 aa)
gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
W5M045_LEPOCProtein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (259 aa)
pik3r4Phosphoinositide-3-kinase, regulatory subunit 4. (1377 aa)
LOC102698371Si:ch73-60h1.1; Belongs to the protein kinase superfamily. (472 aa)
ccn5Uncharacterized protein. (349 aa)
mef2cMyocyte enhancer factor 2ca. (509 aa)
mrasMuscle RAS oncogene homolog. (210 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (273 aa)
LOC107075842PLC-beta_C domain-containing protein. (167 aa)
LOC102694849Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (946 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1192 aa)
adcy9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1361 aa)
gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GABARAPL2GABA(A) receptor-associated protein like 2. (121 aa)
pde3bPhosphodiesterase. (1094 aa)
rras2RAS related 2. (202 aa)
nos1Nitric oxide synthase 1 (neuronal). (1441 aa)
W5M7C3_LEPOCF-box protein 21. (638 aa)
klf2Kruppel-like factor 2a. (391 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (508 aa)
W5M935_LEPOCCellular communication network factor 2b. (343 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1123 aa)
mef2bMyocyte enhancer factor 2b. (425 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
W5MC12_LEPOCUncharacterized protein. (608 aa)
rradRas-related associated with diabetes. (310 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (296 aa)
W5MDZ0_LEPOCMyosin light chain kinase 3. (745 aa)
mylkMyosin, light chain kinase a. (1873 aa)
W5MEC4_LEPOCSodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (676 aa)
nos2Nitric oxide synthase; Produces nitric oxide (NO). (1145 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (400 aa)
LOC102689101Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
CALML6Calmodulin like 6. (156 aa)
LOC102689307Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
LOC102696120Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
mylk2Protein kinase domain-containing protein. (735 aa)
gnb1Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2541 aa)
W5MHD6_LEPOCTranscription factor A, mitochondrial. (293 aa)
W5MHT6_LEPOCRAS (RAD and GEM)-like GTP-binding 1. (301 aa)
snapinSNAP associated protein. (199 aa)
W5MIF3_LEPOCMothers against decapentaplegic homolog. (556 aa)
W5MJN0_LEPOCNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (492 aa)
W5MJS7_LEPOCNotch receptor 3. (2443 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
W5MKY0_LEPOCAdenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (330 aa)
gnb3Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (341 aa)
W5MNE8_LEPOCMyocyte enhancer factor 2d. (405 aa)
LOC102692047Zgc:92606. (117 aa)
prkacbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (396 aa)
W5MPS8_LEPOCUncharacterized protein. (1633 aa)
prkaa2Non-specific serine/threonine protein kinase. (551 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
W5MRU6_LEPOCHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1053 aa)
ucp1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
W5MSI7_LEPOCGuanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (115 aa)
W5MSJ8_LEPOCGuanylate cyclase domain-containing protein. (209 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (860 aa)
myl3Myosin, light chain 13. (187 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (488 aa)
LOC102686598Uncharacterized protein. (361 aa)
klf4Kruppel-like factor 4. (414 aa)
W5MV05_LEPOCUncharacterized protein; Belongs to the protein kinase superfamily. (344 aa)
gng5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
gemGTP binding protein overexpressed in skeletal muscle. (240 aa)
camk4Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. (370 aa)
CSDE1Cold shock domain containing E1. (900 aa)
nrasNRAS proto-oncogene, GTPase. (189 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
gnai2Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
LOC102694494Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
prkag3Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (339 aa)
itpr1Inositol 1,4,5-trisphosphate receptor, type 1b. (2772 aa)
W5MZ39_LEPOC40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (274 aa)
ttc33Non-specific serine/threonine protein kinase. (561 aa)
becn1Beclin 1, autophagy related. (449 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1073 aa)
W5N1X5_LEPOCMyosin, light chain kinase 5. (807 aa)
gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC102690587Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (833 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
itpr3Inositol 1,4,5-trisphosphate receptor, type 3. (2667 aa)
LOC102688108Guanine nucleotide binding protein (G protein) alpha v1. (364 aa)
RYR3Ryanodine receptor 3. (4856 aa)
prkag2Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (557 aa)
adcy8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1224 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1285 aa)
W5N5D9_LEPOCMothers against decapentaplegic homolog. (547 aa)
LOC102691822Uncharacterized protein. (133 aa)
W5N5S6_LEPOCMyosin light chain kinase family, member 4b. (744 aa)
gngt2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
W5N676_LEPOCHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (996 aa)
adcy1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1122 aa)
LOC102699081Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1091 aa)
myl4Myosin, light chain 4, alkali; atrial, embryonic. (187 aa)
W5N6Q5_LEPOCMajor facilitator superfamily domain containing 6-like. (619 aa)
W5N6R2_LEPOCPhosphoinositide-3-kinase, regulatory subunit 6b. (757 aa)
pik3r5Phosphoinositide-3-kinase, regulatory subunit 5. (855 aa)
gnb5Guanine nucleotide binding protein (G protein), beta 5b. (531 aa)
SPHK1Sphingosine kinase 1. (465 aa)
W5N7N1_LEPOCGuanine nucleotide binding protein (G protein), beta polypeptide 2. (213 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
smad3Mothers against decapentaplegic homolog. (427 aa)
W5N977_LEPOCCalmodulin-like 4b. (161 aa)
slc8a3Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (391 aa)
W5NAB3_LEPOCRyanodine receptor 1b (skeletal). (4944 aa)
W5NAH0_LEPOCUncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (855 aa)
W5NAN4_LEPOCPerilipin; Belongs to the perilipin family. (372 aa)
mef2aMyocyte enhancer factor 2aa. (521 aa)
gabarapGABA(A) receptor-associated protein a. (143 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
calm1Uncharacterized protein; Belongs to the calmodulin family. (197 aa)
gng8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
W5NCY7_LEPOCSodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (635 aa)
aplnApelin. (77 aa)
W5NDZ4_LEPOCInositol 1,4,5-trisphosphate receptor, type 2. (2696 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
W5NE85_LEPOCNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (469 aa)
W5NF09_LEPOCPlasminogen activator; Belongs to the peptidase S1 family. (578 aa)
slc8a1Solute carrier family 8 member 1b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1105 aa)
adcy3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1142 aa)
nrf1Nuclear respiratory factor 1. (505 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (153 aa)
prkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1190 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
W5NIQ4_LEPOCRyanodine receptor 2b (cardiac). (4970 aa)
LOC102694194Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1197 aa)
ccn2Cellular communication network factor 2a. (353 aa)
W5NLD7_LEPOCUncharacterized protein. (199 aa)
agtr1Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (351 aa)
LOC102685279Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Your Current Organism:
Lepisosteus oculatus
NCBI taxonomy Id: 7918
Other names: L. oculatus, spotted gar
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