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acpP acpP AEH22140.1 AEH22140.1 ilvD ilvD tpiA tpiA pgk pgk AEH22225.1 AEH22225.1 eno eno AEH22324.1 AEH22324.1 AEH22408.1 AEH22408.1 AEH22515.1 AEH22515.1 tal tal AEH22605.1 AEH22605.1 AEH22735.1 AEH22735.1 AEH22738.1 AEH22738.1 AEH22740.1 AEH22740.1 ilvC ilvC AEH22770.1 AEH22770.1 dtd dtd AEH22772.1 AEH22772.1 AEH22773.1 AEH22773.1 AEH22774.1 AEH22774.1 AEH22775.1 AEH22775.1 AEH22777.1 AEH22777.1 fbp fbp AEH22814.1 AEH22814.1 AEH22815.1 AEH22815.1 AEH22825.1 AEH22825.1 apgM apgM AEH22985.1 AEH22985.1 AEH23003.1 AEH23003.1 AEH23136.1 AEH23136.1 leuC leuC leuD leuD AEH23383.1 AEH23383.1 pfkA pfkA AEH23465.1 AEH23465.1 AEH23466.1 AEH23466.1 AEH23467.1 AEH23467.1 AEH23479.1 AEH23479.1 AEH23480.1 AEH23480.1 AEH23481.1 AEH23481.1 rnhA rnhA AEH23639.1 AEH23639.1 AEH23640.1 AEH23640.1 AEH23676.1 AEH23676.1 AEH23677.1 AEH23677.1 AEH23678.1 AEH23678.1 AEH23679.1 AEH23679.1 AEH23691.1 AEH23691.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa)
AEH22140.1TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: sat:SYN_00123 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT. (526 aa)
ilvDPFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: dak:DaAHT2_2250 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
pgkHAMAP: Phosphoglycerate kinase; KEGG: ddf:DEFDS_1892 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa)
AEH22225.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (811 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
AEH22324.12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. (545 aa)
AEH22408.1PFAM: Phosphoglucose isomerase (PGI); KEGG: sfu:Sfum_1952 phosphoglucose isomerase; Belongs to the GPI family. (573 aa)
AEH22515.1Glucokinase; KEGG: plu:plu1405 glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (313 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
AEH22605.1TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: bld:BLi04084 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (356 aa)
AEH22735.1KEGG: tye:THEYE_A1654 acetyl-CoA synthetase; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; PFAM: CoA-binding; ATP-grasp fold, succinyl-CoA synthetase-type. (699 aa)
AEH22738.1Acetate--CoA ligase; KEGG: reh:H16_A1616 acetyl-coenzyme A synthetase; PFAM: AMP-dependent synthetase/ligase. (691 aa)
AEH22740.1D-lactate dehydrogenase; KEGG: saf:SULAZ_1655 glyoxylate reductase (glycolate reductase); PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region. (349 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
AEH22770.1KEGG: dau:Daud_1123 hypothetical protein. (329 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (152 aa)
AEH22772.1PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: drt:Dret_0089 pyruvate/ketoisovalerate oxidoreductase. (188 aa)
AEH22773.12-oxoglutarate synthase; KEGG: chy:CHY_1971 putative keto/oxoacid ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (253 aa)
AEH22774.13-methyl-2-oxobutanoate dehydrogenase (ferredoxin); KEGG: dbr:Deba_1953 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (360 aa)
AEH22775.1KEGG: fno:Fnod_0110 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; manually curated; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup. (69 aa)
AEH22777.1KEGG: nth:Nther_2750 glycine cleavage system H protein; HAMAP: Glycine cleavage H-protein; PFAM: Glycine cleavage H-protein. (144 aa)
fbpProtein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (368 aa)
AEH22814.1Pyruvate carboxylase; KEGG: rca:Rcas_2955 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal. (484 aa)
AEH22815.1Pyruvate carboxylase; KEGG: rca:Rcas_2954 biotin/lipoyl attachment domain-containing protein; PFAM: Biotin/lipoyl attachment; Conserved carboxylase region; Pyruvate carboxyltransferase. (688 aa)
AEH22825.1TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; KEGG: sfu:Sfum_2174 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (530 aa)
apgMPhosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (407 aa)
AEH22985.1KEGG: iag:Igag_1482 aldehyde ferredoxin oxidoreductase; PFAM: Aldehyde ferredoxin oxidoreductase, N-terminal; Aldehyde ferredoxin oxidoreductase, C-terminal; SMART: Aldehyde ferredoxin oxidoreductase, N-terminal. (653 aa)
AEH23003.1KEGG: tye:THEYE_A0114 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (359 aa)
AEH23136.1TIGRFAM: Pyruvate kinase; KEGG: pmx:PERMA_0022 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; Belongs to the pyruvate kinase family. (478 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (429 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa)
AEH23383.1KEGG: tye:THEYE_A1945 hypothetical protein. (420 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (448 aa)
AEH23465.1Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); KEGG: dpr:Despr_3152 glyceraldehyde 3-phosphate dehydrogenase, NAD(P)-binding domain-containing protein; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (415 aa)
AEH23466.1KEGG: dak:DaAHT2_2096 pyruvate phosphate dikinase PEP/pyruvate-binding protein; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region. (1386 aa)
AEH23467.1KEGG: tpe:Tpen_0757 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
AEH23479.1TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: dsa:Desal_2398 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (563 aa)
AEH23480.1KEGG: dak:DaAHT2_0726 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (165 aa)
AEH23481.11-deoxy-D-xylulose-5-phosphate synthase; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase, N-terminal; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal. (648 aa)
rnhARibonuclease H; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (373 aa)
AEH23639.1TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II. (400 aa)
AEH23640.1Putative cache sensor protein; PFAM: Pyruvate carboxyltransferase; Cache; KEGG: sfu:Sfum_3301 pyruvate carboxyltransferase. (600 aa)
AEH23676.1TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; KEGG: dbr:Deba_3204 pyruvate/ketoisovalerate oxidoreductase, subunit gamma; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (185 aa)
AEH23677.1KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase subunit delta; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup. (97 aa)
AEH23678.1KEGG: dbr:Deba_3202 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal. (389 aa)
AEH23679.1Pyruvate synthase; KEGG: sfu:Sfum_2795 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (317 aa)
AEH23691.1TIGRFAM: Homoserine kinase, putative; Cofactor-independent phosphoglycerate mutase, archaeal; KEGG: tye:THEYE_A1682 proposed homoserine kinase; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme. (435 aa)
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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