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| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: slp:Slip_2175 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (122 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | AEH22325.1 | 3-deoxy-7-phosphoheptulonate synthase; KEGG: afr:AFE_2671 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA. (368 aa) |
| | AEH22336.1 | KEGG: aae:aq_052 4-hydroxybenzoate octaprenyltransferase; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase related; PFAM: UbiA prenyltransferase; Belongs to the UbiA prenyltransferase family. (292 aa) |
| | AEH22382.1 | ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR; KEGG: aps:CFPG_329 cob(I)alamin adenosyltransferase. (174 aa) |
| | mqnC | Menaquinone biosynthesis protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (352 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (278 aa) |
| | AEH22389.1 | KEGG: adg:Adeg_1793 beta-lactamase domain protein. (274 aa) |
| | AEH22398.1 | 4-hydroxybenzoyl-CoA thioesterase; KEGG: dps:DP1730 hypothetical protein; TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase; PFAM: Thioesterase superfamily. (134 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (442 aa) |
| | AEH22408.1 | PFAM: Phosphoglucose isomerase (PGI); KEGG: sfu:Sfum_1952 phosphoglucose isomerase; Belongs to the GPI family. (573 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | AEH22475.1 | PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; manually curated; KEGG: tye:THEYE_A1015 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (165 aa) |
| | AEH22477.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: hth:HTH_1533 myo-inositol-1-phosphate synthase. (368 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa) |
| | AEH22525.1 | KEGG: dal:Dalk_3856 radical SAM domain protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (364 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | AEH22558.1 | Alcohol dehydrogenase; KEGG: tye:THEYE_A1984 NADH-dependent butanol dehydrogenase A; PFAM: Alcohol dehydrogenase, iron-type. (383 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; HAMAP: 3-deoxy-8-phosphooctulonate synthase; KEGG: hya:HY04AAS1_1603 2-dehydro-3-deoxyphosphooctonate aldolase. (264 aa) |
| | argG | PFAM: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: tsc:TSC_c02740 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | AEH22605.1 | TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: bld:BLi04084 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (356 aa) |
| | AEH22608.1 | TIGRFAM: FO synthase, subunit 2; PFAM: Radical SAM; KEGG: tam:Theam_0970 radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (370 aa) |
| | AEH22611.1 | KEGG: pvi:Cvib_0642 hypothetical protein. (497 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (192 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (382 aa) |
| | AEH22634.1 | Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: toc:Toce_1233 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase. (305 aa) |
| | carA | TIGRFAM: Carbamoyl phosphate synthase, small subunit; KEGG: dak:DaAHT2_0900 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (377 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (295 aa) |
| | AEH22663.1 | Menaquinone biosynthesis decarboxylase, SCO4490 family; KEGG: ddf:DEFDS_1642 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD; TIGRFAM: menaquinone biosynthesis decarboxylase, SCO4490 family; Carboxylyase-related; PFAM: Carboxylyase-related; Belongs to the UbiD family. (489 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (126 aa) |
| | trpC | KEGG: nsa:Nitsa_0802 indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | AEH22697.1 | KEGG: aae:aq_1960 HMP-P kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (261 aa) |
| | AEH22717.1 | PFAM: Prephenate dehydrogenase; KEGG: mmx:MmarC6_1158 prephenate dehydrogenase. (274 aa) |
| | AEH22724.1 | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: adg:Adeg_1981 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (218 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: clj:CLJU_c11710 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase. (242 aa) |
| | AEH22739.1 | Alcohol dehydrogenase; KEGG: tye:THEYE_A1984 NADH-dependent butanol dehydrogenase A; PFAM: Alcohol dehydrogenase, iron-type. (381 aa) |
| | AEH22741.1 | TIGRFAM: Riboflavin-specific deaminase, C-terminal; KEGG: tal:Thal_0895 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)p yrimidine1-reductase; PFAM: Bacterial bifunctional deaminase-reductase, C-terminal. (220 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | AEH22776.1 | TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; KEGG: dal:Dalk_3440 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (311 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (368 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (349 aa) |
| | AEH22815.1 | Pyruvate carboxylase; KEGG: rca:Rcas_2954 biotin/lipoyl attachment domain-containing protein; PFAM: Biotin/lipoyl attachment; Conserved carboxylase region; Pyruvate carboxyltransferase. (688 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | hisB | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: mgm:Mmc1_2938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | AEH22826.1 | Aspartate kinase; KEGG: tye:THEYE_A1522 asparate kinase, monofunctional class; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family. (413 aa) |
| | AEH22830.1 | PFAM: Tetrapyrrole methylase; KEGG: ppd:Ppro_1250 uroporphyrin-III C/tetrapyrrole methyltransferase. (273 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | AEH23003.1 | KEGG: tye:THEYE_A0114 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. (359 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (254 aa) |
| | trpF | KEGG: hth:HTH_0191 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (206 aa) |
| | AEH23069.1 | PFAM: Creatininase; KEGG: sfu:Sfum_0661 creatininase. (239 aa) |
| | AEH23073.1 | TIGRFAM: Sirohaem synthase, N-terminal; KEGG: adg:Adeg_1261 siroheme synthase. (231 aa) |
| | AEH23081.1 | KEGG: tye:THEYE_A1986 homoserine dehydrogenase (HDH): ThrA, MetL; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. (431 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (312 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | hisC | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | AEH23256.1 | PFAM: Ferredoxin; KEGG: dak:DaAHT2_1982 ferredoxin. (623 aa) |
| | AEH23292.1 | KEGG: tye:THEYE_A0001 cobyrinic acid a,c-diamide synthase; TIGRFAM: Cobyrinic acid a,c-diamide synthase CbiA; PFAM: CobB/CobQ-like glutamine amidotransferase; Cobyrinic acid a,c-diamide synthase. (464 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (377 aa) |
| | AEH23305.1 | Peptidase dimerization domain protein; PFAM: Peptidase M20, dimerisation; Peptidase M20; KEGG: afu:AF0522 acetylornithine deacetylase. (331 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (455 aa) |
| | AEH23335.1 | PFAM: Ketopantoate reductase ApbA/PanE, N-terminal; KEGG: tye:THEYE_A1653 2-dehydropantoate 2-reductase. (91 aa) |
| | AEH23336.1 | KEGG: hth:HTH_0871 ferredoxin-dependent glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal. (1466 aa) |
| | AEH23338.1 | TIGRFAM: Glutamine synthetase type I; KEGG: tye:THEYE_A1685 glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic region; Glutamine synthetase, beta-Grasp. (445 aa) |
| | AEH23355.1 | KEGG: dak:DaAHT2_0462 hypothetical protein. (220 aa) |
| | carB | TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; KEGG: dal:Dalk_3481 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; Belongs to the CarB family. (1087 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (429 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | AEH23380.1 | KEGG: dth:DICTH_0796 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: Beta-ketoacyl synthase, C-terminal; Beta-ketoacyl synthase, N-terminal; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (420 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (122 aa) |
| | AEH23394.1 | PFAM: Cobalamin (vitamin B12) biosynthesis CbiM; KEGG: tye:THEYE_A1920 CbiM. (198 aa) |
| | AEH23396.1 | KEGG: dal:Dalk_5194 hypothetical protein. (350 aa) |
| | AEH23427.1 | Queuosine biosynthesis protein QueD; KEGG: ddf:DEFDS_1007 6-pyruvoyl-tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. (123 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (213 aa) |
| | AEH23446.1 | TIGRFAM: Dihydropteroate synthase; KEGG: tam:Theam_0893 dihydropteroate synthase; PFAM: Dihydropteroate synthase, DHPS. (280 aa) |
| | AEH23479.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: dsa:Desal_2398 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (563 aa) |
| | AEH23480.1 | KEGG: dak:DaAHT2_0726 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (165 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (351 aa) |
| | AEH23565.1 | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: cdl:CDR20291_2579 putative phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | AEH23577.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: cni:Calni_2007 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal. (435 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (226 aa) |
| | AEH23584.1 | KEGG: sfu:Sfum_3056 radical SAM domain-containing protein; PFAM: Radical SAM; SMART: Elongator protein 3/MiaB/NifB. (389 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (376 aa) |
| | AEH23604.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: tye:THEYE_A1043 bifunctional protein argHA; Belongs to the acetyltransferase family. (149 aa) |
| | AEH23610.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: tye:THEYE_A1148 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (315 aa) |
| | AEH23634.1 | TIGRFAM: Threonine synthase; KEGG: gme:Gmet_1631 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (463 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (222 aa) |
| | AEH23694.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (370 aa) |
| | argH | PFAM: Fumarate lyase; TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: dte:Dester_1517 argininosuccinate lyase. (463 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | AEH23710.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (128 aa) |
| | AEH22132.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | AEH22140.1 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; KEGG: sat:SYN_00123 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT. (526 aa) |
| | fabZ | (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: dak:DaAHT2_2250 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa) |
| | AEH22161.1 | PFAM: Protein of unknown function DUF39; KEGG: sfu:Sfum_1059 hypothetical protein. (396 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (332 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (332 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | AEH22232.1 | PFAM: Nucleoside phosphorylase; KEGG: ppd:Ppro_3274 purine phosphorylases family protein 1. (208 aa) |
| | mqnD | Hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (275 aa) |
