(13 nodes) Pyridoxal phosphate-dependent transferase, major domain network (Thermodesulfobacterium geofontis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	AEH22141.1	KEGG: ddf:DEFDS_2124 serine--glyoxylate transaminase; PFAM: Aminotransferase, class V/Cysteine desulfurase. (387 aa)
	argD	PFAM: Aminotransferase class-III; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: slp:Slip_2175 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
	AEH22350.1	Cysteine desulfurase; KEGG: dth:DICTH_0557 aminotransferase, class V superfamily; PFAM: Aminotransferase, class V/Cysteine desulfurase. (373 aa)
	AEH22476.1	TIGRFAM: LL-diaminopimelate aminotransferase; KEGG: hya:HY04AAS1_0487 LL-diaminopimelate aminotransferase; PFAM: Aminotransferase, class I/II. (385 aa)
	hemL	Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; KEGG: aar:Acear_0548 glutamate-1-semialdehyde 2,1-aminomutase. (427 aa)
	AEH22783.1	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II. (399 aa)
	glyA	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
	AEH23096.1	PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: bcd:BARCL_0291 hypothetical protein; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
	hisC	PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa)
	AEH23303.1	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II. (395 aa)
	AEH23319.1	Glutamine--scyllo-inositol transaminase; KEGG: tsi:TSIB_2051 pyridoxal phosphate-dependent protein; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (374 aa)
	selA	L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (459 aa)
	AEH23639.1	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II. (400 aa)

Your Current Organism:

Thermodesulfobacterium geofontis

NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEH22783.1	AEH23303.1	TOPB45_0681	TOPB45_1216	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	0.917
AEH22783.1	AEH23639.1	TOPB45_0681	TOPB45_1561	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	0.906
AEH22783.1	hisC	TOPB45_0681	TOPB45_1156	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.922
AEH23303.1	AEH22783.1	TOPB45_1216	TOPB45_0681	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	0.917
AEH23303.1	AEH23639.1	TOPB45_1216	TOPB45_1561	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	0.907
AEH23303.1	hisC	TOPB45_1216	TOPB45_1156	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.908
AEH23639.1	AEH22783.1	TOPB45_1561	TOPB45_0681	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	0.906
AEH23639.1	AEH23303.1	TOPB45_1561	TOPB45_1216	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	0.907
AEH23639.1	selA	TOPB45_1561	TOPB45_1560	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.	0.786
hisC	AEH22783.1	TOPB45_1156	TOPB45_0681	PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	KEGG: mgm:Mmc1_0698 L-aspartate aminotransferase; PFAM: Aminotransferase, class I/II.	0.922
hisC	AEH23303.1	TOPB45_1156	TOPB45_1216	PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: dal:Dalk_0935 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Aspartate transaminase; KEGG: dpr:Despr_1050 class I/II aminotransferase; PFAM: Aminotransferase, class I/II.	0.908
selA	AEH23639.1	TOPB45_1560	TOPB45_1561	L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.	TIGRFAM: Tyrosine/nicotianamine aminotransferase; KEGG: aba:Acid345_1458 aminotransferase; PFAM: Aminotransferase, class I/II.	0.786