STRINGSTRING
AEH22144.1 AEH22144.1 lpxA lpxA AEH22240.1 AEH22240.1 AEH22311.1 AEH22311.1 lpxC lpxC AEH22414.1 AEH22414.1 AEH22579.1 AEH22579.1 kdsA kdsA AEH22613.1 AEH22613.1 AEH22614.1 AEH22614.1 AEH22616.1 AEH22616.1 lpxD lpxD gmhA gmhA kdsB kdsB AEH23235.1 AEH23235.1 AEH23252.1 AEH23252.1 AEH23253.1 AEH23253.1 lpxK lpxK hldD hldD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEH22144.1lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa)
lpxAAcyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (269 aa)
AEH22240.1KEGG: maq:Maqu_0789 lipopolysaccharide heptosyltransferase II; TIGRFAM: Lipopolysaccharide heptosyltransferase II; PFAM: Glycosyl transferase, family 9. (318 aa)
AEH22311.1KpsF/GutQ family protein; SMART: Cystathionine beta-synthase, core; TIGRFAM: KpsF/GutQ; KEGG: dak:DaAHT2_1635 KpsF/GutQ family protein; PFAM: Sugar isomerase (SIS); Cystathionine beta-synthase, core; Belongs to the SIS family. GutQ/KpsF subfamily. (328 aa)
lpxCUDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (301 aa)
AEH22414.1rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (404 aa)
AEH22579.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; TIGRFAM: Phosphatase KdsC; HAD-superfamily hydrolase, subfamily IIIA; KEGG: tye:THEYE_A0223 bifunctional protein HldE; PFAM: Haloacid dehalogenase-like hydrolase. (177 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; HAMAP: 3-deoxy-8-phosphooctulonate synthase; KEGG: hya:HY04AAS1_1603 2-dehydro-3-deoxyphosphooctonate aldolase. (264 aa)
AEH22613.1PFAM: O-antigen ligase-related; KEGG: cni:Calni_1077 O-antigen polymerase. (409 aa)
AEH22614.1PFAM: Glycosyl transferase, group 1; KEGG: tye:THEYE_A1549 WabG. (352 aa)
AEH22616.1PFAM: Glycosyl transferase, family 39; KEGG: dte:Dester_0129 glycosyl transferase family 39. (537 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (195 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (245 aa)
AEH23235.1Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (416 aa)
AEH23252.1TIGRFAM: Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; KEGG: dpr:Despr_1621 histidinol-phosphate phosphatase family protein; PFAM: Haloacid dehalogenase-like hydrolase. (187 aa)
AEH23253.1KEGG: tye:THEYE_A0945 lipopolysaccharide heptosyltransferase II; TIGRFAM: Lipopolysaccharide heptosyltransferase I; Lipopolysaccharide heptosyltransferase II; PFAM: Glycosyl transferase, family 9. (343 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (316 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (327 aa)
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.