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rplY rplY rpmF rpmF rpsO rpsO rplL rplL rplJ rplJ rplA rplA rplK rplK rpmG rpmG rplI rplI rpsR rpsR rpsF rpsF rpmE rpmE rplT rplT rpmI rpmI rpmH rpmH rpsP rpsP rplM rplM rpsI rpsI rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsZ rpsZ rpsH rpsH rplF rplF rplR rplR rpsE rpsE AEH22872.1 AEH22872.1 rplO rplO rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD rpsD rplQ rplQ rpsU rpsU AEH22933.1 AEH22933.1 rplS rplS rpsB rpsB rplU rplU rpmA rpmA rpmB rpmB rpsT rpsT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (201 aa)
rpmFTIGRFAM: Ribosomal protein L32p; HAMAP: Ribosomal protein L32p; KEGG: geo:Geob_2610 50S ribosomal protein L32; PFAM: Ribosomal protein L32p; Belongs to the bacterial ribosomal protein bL32 family. (63 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (129 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (171 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (239 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rpmGTIGRFAM: Ribosomal protein L33; HAMAP: Ribosomal protein L33; KEGG: tam:Theam_1586 ribosomal protein L33; PFAM: Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (148 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (84 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (118 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (74 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
rpmITIGRFAM: Ribosomal protein L35; HAMAP: Ribosomal protein L35; KEGG: tye:THEYE_A1227 50S ribosomal protein L35; PFAM: Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (68 aa)
rpmHTIGRFAM: Ribosomal protein L34; HAMAP: 50S ribosomal protein L34; KEGG: tme:Tmel_1628 50S ribosomal protein L34; PFAM: Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rpsPTIGRFAM: Ribosomal protein S16; HAMAP: Ribosomal protein S16; KEGG: cth:Cthe_0769 30S ribosomal protein S16; PFAM: Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (85 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
rpsIPFAM: Ribosomal protein S9; KEGG: ckn:Calkro_0588 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (129 aa)
rpsLRibosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (123 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (157 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (215 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (210 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (96 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (96 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (119 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (220 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpmCKEGG: nth:Nther_0202 LSU ribosomal protein L29P; TIGRFAM: Ribosomal protein L29; PFAM: Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (65 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (96 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (122 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsZRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (131 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (194 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (129 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (167 aa)
AEH22872.1KEGG: tme:Tmel_0971 50S ribosomal protein L30; TIGRFAM: Ribosomal protein L30, bacterial-type; PFAM: Ribosomal protein L30p/L7e, conserved region. (61 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (153 aa)
rpmJTIGRFAM: Ribosomal protein L36; HAMAP: Ribosomal protein L36; KEGG: tam:Theam_0281 ribosomal protein L36; PFAM: Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (123 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (128 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (210 aa)
rplQTIGRFAM: Ribosomal protein L17; HAMAP: 50S ribosomal protein L17; KEGG: ppd:Ppro_0707 50S ribosomal protein L17; PFAM: Ribosomal protein L17. (166 aa)
rpsUTIGRFAM: Ribosomal protein S21; HAMAP: Ribosomal protein S21; KEGG: pmx:PERMA_0135 30S ribosomal protein S21; PFAM: Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (69 aa)
AEH22933.1PFAM: Ribosomal protein S1, RNA binding domain; KEGG: tth:TTC1824 30S ribosomal protein S1. (476 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (121 aa)
rpsBRibosomal protein S2; KEGG: glo:Glov_2708 30S ribosomal protein S2; TIGRFAM: Ribosomal protein S2, bacteria/mitochondria/plastid; PFAM: Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (281 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpmATIGRFAM: Ribosomal protein L27; HAMAP: Ribosomal protein L27; KEGG: sta:STHERM_c10280 50S ribosomal protein L27; PFAM: Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (83 aa)
rpmBTIGRFAM: Ribosomal protein L28; HAMAP: Ribosomal protein L28; KEGG: kol:Kole_1660 ribosomal protein L28; PFAM: Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (65 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (93 aa)
Your Current Organism:
Thermodesulfobacterium geofontis
NCBI taxonomy Id: 795359
Other names: T. geofontis OPF15, Thermodesulfobacterium geofontis OPF15, Thermodesulfobacterium sp. OPF15
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