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apoa1b apoa1b actn3b actn3b pdhb pdhb atp5pb atp5pb atp5po atp5po eno1a eno1a actn3a actn3a uqcrc2b uqcrc2b glud1a glud1a mybpc1 mybpc1 myhb myhb atp1a1a.5 atp1a1a.5 ldhba ldhba vdac2 vdac2 uqcrc2a uqcrc2a vim vim dldh dldh acat2 acat2 aldoaa aldoaa atp1a1b atp1a1b slc25a6 slc25a6 mdh1aa mdh1aa atp1a1a.2 atp1a1a.2 got2b got2b ckbb ckbb flncb flncb pygb pygb idh2 idh2 atp5fa1 atp5fa1 ndufs1 ndufs1 slc25a4 slc25a4 nnt nnt tpi1a tpi1a tpm4a tpm4a ckma ckma fabp3 fabp3 mb mb acsl1a acsl1a myl7 myl7 atp2a2a atp2a2a aldoab aldoab ogdha ogdha flnca flnca atp2a2b atp2a2b cmlc1 cmlc1 atp1a1a.4 atp1a1a.4 hadh hadh acta1a acta1a acaa2 acaa2 hk1 hk1 ckmt2b ckmt2b acta1b acta1b apoa2 apoa2 tpi1b tpi1b got2a got2a atp5f1b atp5f1b actc1a actc1a obscna obscna mdh2 mdh2 gapdh gapdh desmb desmb atp5f1c atp5f1c zgc:66156 zgc:66156 pklr pklr hadhab hadhab pgk1 pgk1 ngs ngs pygma pygma hspd1 hspd1 ldb3a ldb3a hadhaa hadhaa aldoca aldoca zgc:86709 zgc:86709 atp1a1a.1 atp1a1a.1 desma desma myh7ba myh7ba wu:fd14a01 wu:fd14a01 viml viml LOC572200 LOC572200 myh7 myh7 ckmt2a ckmt2a hbba1 hbba1 sptan1 sptan1 atp1a1a.3 atp1a1a.3 ldhbb ldhbb slc25a5 slc25a5 A2CEZ0_DANRE A2CEZ0_DANRE fh fh ttn.2 ttn.2 tfa tfa ENSDARP00000100434 ENSDARP00000100434 bY187G17.1-001 bY187G17.1-001 hbaa1 hbaa1 myhz1.1 myhz1.1 myhc4 myhc4 ttn.1 ttn.1 myhz2 myhz2 myh6 myh6 uqcrc1 uqcrc1 ba1l ba1l acsl1b acsl1b myh7l myh7l myhz1.3 myhz1.3 acadvl acadvl flna flna eno1b eno1b sptb sptb nnt2 nnt2 flnb flnb myh7bb myh7bb myhz1.2 myhz1.2 actn2b actn2b myha myha aifm1 aifm1 obsl1b obsl1b eno3 eno3 obsl1a obsl1a actn1 actn1 tpm1 tpm1 aco2 aco2 pygmb pygmb tnnt2a tnnt2a tpm3 tpm3 actc1b actc1b tnnt2b tnnt2b slc25a13 slc25a13 tpm2 tpm2 zgc:66156-2 zgc:66156-2 acat1 acat1 immt immt LOC103910030 LOC103910030 myom1b myom1b ckba ckba atp5pd atp5pd slc25a12 slc25a12 ogdhb ogdhb glud1b glud1b cs cs nme2b.2 nme2b.2 hk2 hk2 smyhc2-2 smyhc2-2 smyhc3 smyhc3 tpm4b tpm4b zgc:165653 zgc:165653 smyhc1 smyhc1 LOC100329748 LOC100329748 LOC100329813 LOC100329813 pkma pkma FLNB FLNB smyhc2 smyhc2 obscnb obscnb tpma tpma mybpc3 mybpc3 acta2 acta2 ENSDARP00000145149 ENSDARP00000145149 LOC100535417 LOC100535417 pkmb pkmb actn4 actn4 hadhb hadhb aldocb aldocb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
apoa1bApolipoprotein A-Ib. (257 aa)
actn3bActinin alpha 3b. (898 aa)
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
atp5pbATP synthase peripheral stalk-membrane subunit b. (252 aa)
atp5poATP synthase, H+ transporting, mitochondrial F1 complex, O subunit. (209 aa)
eno1aEnolase 1a, (alpha). (432 aa)
actn3aActinin alpha 3a. (896 aa)
uqcrc2bUbiquinol-cytochrome c reductase core protein 2b; Belongs to the peptidase M16 family. (454 aa)
glud1aGlutamate dehydrogenase 1a; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (544 aa)
mybpc1Myosin-binding protein C1. (1167 aa)
myhbMyosin, heavy chain b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
atp1a1a.5Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
ldhbaL-lactate dehydrogenase B-A chain; Belongs to the LDH/MDH superfamily. LDH family. (334 aa)
vdac2Voltage-dependent anion channel 2. (283 aa)
uqcrc2aUbiquinol-cytochrome c reductase core protein 2a. (460 aa)
vimVimentin; Belongs to the intermediate filament family. (455 aa)
dldhDihydrolipoyl dehydrogenase. (507 aa)
acat2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
aldoaaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
atp1a1bSodium/potassium-transporting ATPase subunit alpha. (1025 aa)
slc25a6Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
mdh1aaMalate dehydrogenase. (333 aa)
atp1a1a.2Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
got2bAspartate aminotransferase. (428 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
flncbFilamin C, gamma b (actin-binding protein 280). (2773 aa)
pygbAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)
atp5fa1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
ndufs1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (731 aa)
slc25a4Solute carrier family 25 (Mitochondrial carrier adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
nntNicotinamide nucleotide transhydrogenase. (1079 aa)
tpi1aTriosephosphate isomerase A; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
fabp3Fatty acid-binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
mbMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
acsl1aAcyl-CoA synthetase long chain family member 1a. (697 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
atp2a2aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (996 aa)
aldoabFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ogdhaOxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide). (175 aa)
flncaFilamin C, gamma a (actin-binding protein 280). (2719 aa)
atp2a2bCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1035 aa)
cmlc1Cardiac myosin light chain-1. (196 aa)
atp1a1a.4Sodium/potassium-transporting ATPase subunit alpha. (1024 aa)
hadhHydroxyacyl-Coenzyme A dehydrogenase. (309 aa)
acta1aActin alpha 1, skeletal muscle a. (377 aa)
acaa2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
hk1Hexokinase 1. (918 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
apoa2Apolipoprotein A-II. (141 aa)
tpi1bTriosephosphate isomerase B; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
got2aAspartate aminotransferase. (428 aa)
atp5f1bATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (517 aa)
actc1aActin, alpha, cardiac muscle 1a. (377 aa)
obscnaObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a. (1992 aa)
mdh2Malate dehydrogenase. (337 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
desmbDesmin b; Belongs to the intermediate filament family. (473 aa)
atp5f1cATP synthase subunit gamma. (292 aa)
zgc:66156Zgc:66156; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (555 aa)
pklrPyruvate kinase; Belongs to the pyruvate kinase family. (538 aa)
hadhabHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
pgk1Phosphoglycerate kinase. (417 aa)
ngsNotochord granular surface; Belongs to the intermediate filament family. (539 aa)
pygmaAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
hspd1Heat shock 60kD protein 1 (Chaperonin); Belongs to the chaperonin (HSP60) family. (575 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
hadhaaHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a; Belongs to the enoyl-CoA hydratase/isomerase family. (761 aa)
aldocaFructose-bisphosphate aldolase C-A. (364 aa)
zgc:86709Novel actin protein. (377 aa)
atp1a1a.1Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
desmaDesmin a; Belongs to the intermediate filament family. (488 aa)
myh7baMyosin, heavy chain 7B, cardiac muscle, beta a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1945 aa)
wu:fd14a01Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1631 aa)
vimlVimentin-like; Belongs to the intermediate filament family. (447 aa)
LOC572200Vimentin-related 1; Belongs to the intermediate filament family. (236 aa)
myh7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
hbba1Hemoglobin subunit beta-1; Involved in oxygen transport from gills to the various peripheral tissues; Belongs to the globin family. (148 aa)
sptan1Spectrin alpha, non-erythrocytic 1. (2480 aa)
atp1a1a.3Sodium/potassium-transporting ATPase subunit alpha. (1024 aa)
ldhbbL-lactate dehydrogenase B-B chain; Belongs to the LDH/MDH superfamily. LDH family. (334 aa)
slc25a5Solute carrier family 25 member 5 protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
A2CEZ0_DANRESi:dkey-251i10.1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa)
fhFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (509 aa)
ttn.2Titin, tandem duplicate 2. (26265 aa)
tfaSerotransferrin; Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate. (673 aa)
ENSDARP00000100434Actin alpha cardiac muscle 1a. (377 aa)
bY187G17.1-001Novel protein similar to zebrafish hemoglobin alpha-adult 1 (Hbaa1); Belongs to the globin family. (143 aa)
hbaa1Hemoglobin subunit alpha; Involved in oxygen transport from gills to the various peripheral tissues. (143 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
myhc4Myosin heavy chain 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
myhz2Myosin, heavy polypeptide 2, fast muscle-specific; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
myh6Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
uqcrc1Ubiquinol-cytochrome c reductase core protein 1. (503 aa)
ba1lBa1 globin, like. (148 aa)
acsl1bAcyl-CoA synthetase long chain family member 1b. (697 aa)
myh7lMyosin heavy chain 7-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
myhz1.3Myosin, heavy polypeptide 1.3, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
acadvlAcyl-CoA dehydrogenase very long chain. (659 aa)
flnaFilamin A, alpha (actin-binding protein 280). (2553 aa)
eno1bEnolase 1b, (alpha). (433 aa)
sptbSpectrin beta chain; Belongs to the spectrin family. (2357 aa)
nnt2Nicotinamide nucleotide transhydrogenase 2. (802 aa)
flnbFilamin B, beta (actin-binding protein 278). (2233 aa)
myh7bbMyosin, heavy chain 7B, cardiac muscle, beta b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
myhz1.2Myosin, heavy polypeptide 1.2, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
actn2bActinin, alpha 2b. (894 aa)
myhaMyosin, heavy chain a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1933 aa)
aifm1Apoptosis-inducing factor mitochondrion-associated 1. (750 aa)
obsl1bObscurin-like cytoskeletal adaptor 1b. (3304 aa)
eno3Enolase 3, (beta, muscle). (433 aa)
obsl1aObscurin-like cytoskeletal adaptor 1a. (2006 aa)
actn1Actinin, alpha 1. (902 aa)
tpm1Tropomyosin 1 (alpha); Belongs to the tropomyosin family. (284 aa)
aco2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (790 aa)
pygmbAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
tpm3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
actc1bActin, alpha 1, skeletal muscle. (377 aa)
tnnt2bTroponin T type 2b (cardiac). (233 aa)
slc25a13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (664 aa)
tpm2Tropomyosin 2 (beta); Belongs to the tropomyosin family. (284 aa)
zgc:66156-2Zgc:66156; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (561 aa)
acat1Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] (420 aa)
immtMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (757 aa)
LOC103910030Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (237 aa)
myom1bMyomesin 1b. (1632 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
atp5pdATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
slc25a12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (682 aa)
ogdhbOxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (1023 aa)
glud1bGlutamate dehydrogenase 1b; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (542 aa)
csCitrate synthase, mitochondrial. (468 aa)
nme2b.2Nucleoside diphosphate kinase. (153 aa)
hk2Hexokinase 2. (919 aa)
smyhc2-2Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
smyhc3Slow myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
tpm4bTropomyosin 4b. (248 aa)
zgc:165653Zgc:165653 protein. (151 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
LOC100329748Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1390 aa)
LOC100329813Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1946 aa)
pkmaPyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
FLNBFilamin B. (1992 aa)
smyhc2Slow myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
obscnbObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa)
tpmaTropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (284 aa)
mybpc3Myosin-binding protein C3. (1287 aa)
acta2Actin, alpha 2, smooth muscle, aorta. (377 aa)
ENSDARP00000145149Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (184 aa)
LOC100535417Lyase_1 domain-containing protein. (334 aa)
pkmbPyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
actn4Actinin, alpha 4. (923 aa)
hadhbHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (456 aa)
aldocbFructose-bisphosphate aldolase C-B. (363 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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