STRINGSTRING
usp7 usp7 usp33 usp33 rnf128a rnf128a UBB UBB uchl1 uchl1 usp4 usp4 otud7b otud7b rnf123 rnf123 rnf41 rnf41 wdr48b wdr48b siah2l siah2l usp13 usp13 usp11 usp11 usp1 usp1 usp30 usp30 zufsp zufsp vcpip1 vcpip1 zranb1a zranb1a toporsa toporsa uchl3 uchl3 josd1 josd1 wdr20a wdr20a usp12b usp12b usp2b usp2b usp38 usp38 usp12a usp12a otud5b otud5b trim63b trim63b usp48 usp48 otud5a otud5a usp24 usp24 usp19 usp19 usp46 usp46 josd2 josd2 usp45 usp45 usp2a usp2a wdr20b wdr20b usp25 usp25 cylda cylda usp5 usp5 usp8 usp8 shprh shprh klhl7 klhl7 otud6b otud6b Usp15 Usp15 wdr48a wdr48a usp47 usp47 uvssa uvssa otud1 otud1 usp43a usp43a USP53 USP53 ubc ubc ubb ubb usp28 usp28 dub dub ENSDARP00000152229 ENSDARP00000152229 ENSDARP00000157149 ENSDARP00000157149
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
usp7Ubiquitin-specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1110 aa)
usp33Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] (897 aa)
rnf128aRing finger protein 128a. (389 aa)
UBBSi:ch211-202a12.4. (459 aa)
uchl1Ubiquitin carboxyl-terminal hydrolase. (218 aa)
usp4Ubiquitin-specific peptidase 4 (proto-oncogene); Belongs to the peptidase C19 family. (1009 aa)
otud7bOTU deubiquitinase 7B. (917 aa)
rnf123Ring finger protein 123. (1300 aa)
rnf41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. (318 aa)
wdr48bWD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa)
siah2lE3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). (330 aa)
usp13Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). (860 aa)
usp11Ubiquitin carboxyl-terminal hydrolase. (990 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (772 aa)
usp30Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (491 aa)
zufspZinc finger-containing ubiquitin peptidase 1. (608 aa)
vcpip1Valosin-containing protein (p97)/p47 complex-interacting protein 1. (1108 aa)
zranb1aZinc finger, RAN-binding domain-containing 1a. (666 aa)
toporsaTopoisomerase I-binding, arginine/serine-rich a. (999 aa)
uchl3Ubiquitin carboxyl-terminal hydrolase. (230 aa)
josd1Josephin domain-containing 1. (235 aa)
wdr20aWD repeat domain 20a. (596 aa)
usp12bUbiquitin carboxyl-terminal hydrolase. (383 aa)
usp2bUbiquitin carboxyl-terminal hydrolase. (398 aa)
usp38Ubiquitin-specific peptidase 38; Belongs to the peptidase C19 family. (1014 aa)
usp12aUbiquitin carboxyl-terminal hydrolase 12A; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity. (371 aa)
otud5bOTU deubiquitinase 5b. (537 aa)
trim63bTripartite motif-containing 63b. (348 aa)
usp48Ubiquitin-specific peptidase 48; Belongs to the peptidase C19 family. (1092 aa)
otud5aOTU domain-containing protein 5-A; Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity). (560 aa)
usp24Ubiquitin-specific peptidase 24. (1648 aa)
usp19Ubiquitin-specific peptidase 19. (1478 aa)
usp46Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity). (370 aa)
josd2Josephin domain-containing 2. (184 aa)
usp45Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. Belongs to the peptidase C19 family. (803 aa)
usp2aUbiquitin carboxyl-terminal hydrolase. (394 aa)
wdr20bWD repeat domain 20b. (612 aa)
usp25Ubiquitin-specific peptidase 25; Belongs to the peptidase C19 family. (1072 aa)
cyldaCylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (951 aa)
usp5Ubiquitin carboxyl-terminal hydrolase. (834 aa)
usp8Ubiquitin-specific peptidase 8; Belongs to the peptidase C19 family. (1067 aa)
shprhSNF2 histone linker PHD RING helicase. (1644 aa)
klhl7Kelch-like family member 7. (539 aa)
otud6bDeubiquitinase OTUD6B; Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes. (293 aa)
Usp15DUSP domain-containing protein. (143 aa)
wdr48aWD repeat domain 48a. (524 aa)
usp47Ubiquitin-specific peptidase 47; Belongs to the peptidase C19 family. (1354 aa)
uvssaUV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity); Belongs to the UVSSA family. (721 aa)
otud1OTU deubiquitinase 1. (412 aa)
usp43aUbiquitin-specific peptidase 43a; Belongs to the peptidase C19 family. (1122 aa)
USP53USP domain-containing protein. (934 aa)
ubcUbiquitin C. (533 aa)
ubbUbiquitin B. (610 aa)
usp28Ubiquitin-specific peptidase 28; Belongs to the peptidase C19 family. (1223 aa)
dubDuboraya. (305 aa)
ENSDARP00000152229USP domain-containing protein; Belongs to the peptidase C19 family. (141 aa)
ENSDARP00000157149WD_REPEATS_REGION domain-containing protein. (519 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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