STRINGSTRING
yod1 yod1 ubxn6 ubxn6 ubxn7 ubxn7 vcp vcp ufd1l ufd1l ube4a ube4a plaa plaa ubxn10 ubxn10 zgc:136908 zgc:136908 ubxn11 ubxn11 ubxn1 ubxn1 ubxn2a ubxn2a ubxn4 ubxn4 nploc4 nploc4 ubxn8 ubxn8 aspscr1 aspscr1 nsfl1c nsfl1c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yod1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (301 aa)
ubxn6UBX domain protein 6. (437 aa)
ubxn7UBX domain protein 7. (511 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
ufd1lUbiquitin recognition factor in ER-associated degradation 1. (308 aa)
ube4aUbiquitination factor E4A (UFD2 homolog, yeast). (1076 aa)
plaaPhospholipase A2-activating protein. (798 aa)
ubxn10UBX domain-containing protein 10; Required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of vcp/p97 to the intraflagellar transport complex B (IFT-B) in cilia (By similarity). (214 aa)
zgc:136908Zgc:136908; Belongs to the AAA ATPase family. (805 aa)
ubxn11UBX domain protein 11. (482 aa)
ubxn1UBX domain-containing protein 1; Ubiquitin-binding protein that specifically binds 'Lys-6'- linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity). (294 aa)
ubxn2aUBX domain protein 2A. (258 aa)
ubxn4UBX domain protein 4. (126 aa)
nploc4Nuclear protein localization 4 homolog (S. cerevisiae). (624 aa)
ubxn8UBX domain protein 8. (272 aa)
aspscr1ASPSCR1 tether for SLC2A4, UBX domain-containing. (584 aa)
nsfl1cNSFL1 (p97) cofactor (p47). (372 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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