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| | dnmt1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa) |
| | aebp2 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes. (415 aa) |
| | ezh2 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa) |
| | wdr73 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; Belongs to the WD repeat WDR73 family. (376 aa) |
| | suv39h1a | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa) |
| | hat1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (408 aa) |
| | rbbp4 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (424 aa) |
| | hist2h2l | Histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa) |
| | asf1bb | Histone chaperone asf1b-B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (197 aa) |
| | hist1h2a4 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | zgc:173552 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | zgc:194989 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | suv39h1b | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (613 aa) |
| | mphosph8 | M-phase phosphoprotein 8. (946 aa) |
| | hist1h4l | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | jarid2a | Jumonji, AT-rich interactive domain 2a. (1171 aa) |
| | hist1h4l-2 | Zgc:153409. (103 aa) |
| | jarid2b | Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] (1319 aa) |
| | zgc:113983 | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa) |
| | kat2b | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa) |
| | h3f3a-2 | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa) |
| | h2az2a | Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] (128 aa) |
| | hist1h2a10 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | h2ax1 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | dnmt3aa | DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (852 aa) |
| | ezh1 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. (147 aa) |
| | suz12a | Polycomb protein suz12-A; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (657 aa) |
| | hist1h2a3 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | ENSDARP00000099321 | Histone H3.2. (136 aa) |
| | zgc:173587 | Histone H2B 1/2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (124 aa) |
| | chaf1a | Chromatin assembly factor 1 subunit A; May be involved in chromatin assembly in DNA replication and DNA repair; Belongs to the CHAF1A family. (863 aa) |
| | hist1h2a5 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC100148591 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | kmt5c | Lysine methyltransferase 5C. (519 aa) |
| | hist1h2a2 | Histone cluster 1 H2A family member 2. (128 aa) |
| | mysm1 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity). (822 aa) |
| | zgc:113984 | Zgc:173552. (136 aa) |
| | dnmt3ba | DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa) |
| | mtf2 | Metal response element-binding transcription factor 2. (605 aa) |
| | dnmt3bb.2 | DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1448 aa) |
| | hist2h3c | Histone cluster 2, H3c. (136 aa) |
| | cbx5 | Chromobox homolog 5 (HP1 alpha homolog, Drosophila). (204 aa) |
| | nasp | Nuclear autoantigenic sperm protein (histone-binding). (622 aa) |
| | h3f3d | H3 histone, family 3D. (136 aa) |
| | zgc:92591 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | phf19 | PHD finger protein 19. (562 aa) |
| | hira | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1010 aa) |
| | h3f3a | H3 histone, family 3B.1. (136 aa) |
| | h3f3b.1 | H3 histone, family 3B.1. (136 aa) |
| | dnmt3ab | DNA (cytosine-5-)-methyltransferase 3 alpha b; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (978 aa) |
| | R4GE02_DANRE | Si:ch211-113a14.11; Belongs to the histone H2A family. (248 aa) |
| | R4GE15_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | zgc:173552-2 | Zgc:173552. (136 aa) |
| | zgc:114046 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | zgc:162611-2 | Si:dkey-108k21.24. (151 aa) |
| | X1WDH8_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ENSDARP00000128298 | Si:dkey-108k21.19. (128 aa) |
| | X1WH60_DANRE | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | X1WHF1_DANRE | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | ehmt2 | Euchromatic histone-lysine N-methyltransferase 2. (1167 aa) |
| | suz12b | Polycomb protein suz12-B; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (682 aa) |
| | ENSDARP00000130595 | Histone H3.2. (136 aa) |
| | eed | Polycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (443 aa) |
| | ppiab | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | zgc:158376 | Zgc:158376. (765 aa) |
| | ENSDARP00000135695 | Histone H3.2. (136 aa) |
| | zgc:173552-3 | Zgc:173552. (136 aa) |
| | h2af1al | Histone H2A; Belongs to the histone H2A family. (140 aa) |
| | ENSDARP00000139024 | Histone H3.2. (136 aa) |
| | macroh2a1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (357 aa) |
| | asf1ba | Histone chaperone asf1b-A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (197 aa) |
| | ENSDARP00000140767 | Histone H3.2. (136 aa) |
| | hist1h2a6 | Histone H2A; Belongs to the histone H2A family. (127 aa) |
| | ENSDARP00000142122 | Histone H3.2. (136 aa) |
| | hist2h3ca1 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | ENSDARP00000142232 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | hist1h4l-7 | Histone 1, H4, like. (103 aa) |
| | ENSDARP00000142272 | Histone H3.2. (136 aa) |
| | ENSDARP00000142451 | Histone H2A; Belongs to the histone H2A family. (127 aa) |
| | ENSDARP00000142481 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa) |
| | ENSDARP00000142515 | Histone H3.2. (136 aa) |
| | phf14 | PHD finger protein 14. (914 aa) |
| | kdm2ab | Lysine (K)-specific demethylase 2Ab. (1271 aa) |
| | tet3 | Tet methylcytosine dioxygenase 3. (2052 aa) |
| | ENSDARP00000145961 | Histone H3.2. (136 aa) |
| | ENSDARP00000146454 | Histone H3.2. (136 aa) |
| | h3f3c | H3 histone, family 3C. (136 aa) |
| | zgc:173552-4 | Zgc:173552. (136 aa) |
| | ENSDARP00000149802 | Si:dkey-261m9.8. (136 aa) |
| | hist1h4l-19 | Histone 1, H4, like. (103 aa) |
| | zgc:173552-5 | Zgc:173552. (136 aa) |
| | kdm2ba | Lysine (K)-specific demethylase 2Ba. (883 aa) |
| | ENSDARP00000153520 | Si:ch73-36p18.2. (136 aa) |
| | zgc:173552-6 | Zgc:173552. (136 aa) |
| | zgc:173552-7 | Zgc:173552. (136 aa) |
| | ENSDARP00000156321 | Si:dkey-108k21.25. (136 aa) |
