STRINGSTRING
rfx4 rfx4 rfx2 rfx2 rfx3 rfx3 rfx7a rfx7a dzip1l dzip1l gmnc gmnc ccno ccno foxj1a foxj1a pcsk6 pcsk6 mcidas mcidas
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfx4Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family. (735 aa)
rfx2DNA-binding protein RFX2; Transcription factor that acts as a key regulator of ciliogenesis. Specifically regulates expression of genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity). Belongs to the RFX family. (734 aa)
rfx3Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development; Belongs to the RFX family. (765 aa)
rfx7aRegulatory factor X7a. (1509 aa)
dzip1lZinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane. Belongs to the DZIP C2H2-type zinc-finger protein family. (794 aa)
gmncGeminin coiled-coil domain-containing. (382 aa)
ccnoCYCLIN domain-containing protein; Belongs to the cyclin family. (300 aa)
foxj1aForkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. (458 aa)
pcsk6Proprotein convertase subtilisin/kexin type 6. (529 aa)
mcidasUncharacterized protein. (302 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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